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    Comparison of Effects of Three Distinct Stress Models on Anxiety- and Depression-Related Behaviors in Female Rats
    (2019) Şahin, Zafer; Koc, Aynur; Ozen Koca, Raviye; Ozkurkculer, Alpaslan; Cakan, Pinar; Gormus Solak, Z. Isik; Kutlu, Selim
    Abstract: Objective The aim of the present study was to compare the effects of three distinct stress protocols on anxiety/depression-related behaviors in adult female rats.( Sakarya Med J 2019, 9(1): 131-140 )Materialsand MethodsAdult Wistar rats were randomly divided into four groups (n=8/ group) as control, immobilization stress-1 (daily 45 minutes) immobilization stress-2 (daily twice 45minutes) and social isolation (rats were housed in a metabolic cage). Stress protocols were performed for a period of 10 days. When the animals were in diestrus, anxiety anddepression-like behaviors were evaluated by the open field test and forced swimming test, respectively. Anxiety and depression tests were repeated after a 10-day rest period.Results In the open field test, a percentage of time spent in the central area was lower in the immobilization stress-2 and social isolation (p<0.05) groups and total distance was lowerin the immobilization stress-1 (p<0.01) and the social isolation groups (p<0.05). Rearing score was lower in the social isolation group (p<0.05). Swimming behaviors werelower (p<0.01), and immobility durations were higher (p<0.05) in the immobilization stress-1 and social isolation groups. In the second tests, time spent in the central areawas lower in the immobilization stress-1 (p<0.05) and the immobilization stress-2 (p<0.01) groups. Swimming behaviors were lower and immobility behaviors were higherin the immobilization stress-1 group (p<0.001) and the social isolation group (p<0.01 and p<0.001, respectively).Conclusion We suggest that depression-like behaviors are more dominant in the immobilization stress-1 and social isolation groups of adult female rats because the depression-relatedresults of these two groups are valid both after the stress period and after the rest period.
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    An Evaluation of the Effects of Two Chronic Immobilization Stress Protocols on Depression/AnxietyRelated Behavior in Male Rats
    (2019) Şahin, Zafer; Özkürkçüler, Alpaslan; Koç, Aynur; Solak, Hatice; Özen Koca, Raviye; Çakan, Pınar; Solak Görmüş, Zülfikare Işık; Kutlu, Selim
    Abstract: Objective: The effect of acute and chronic stress models on depression and/or anxiety-like behavior in rodents has been widely studied,but with contradictory results. This may be due to differences in the sex and age of the animals studied or inherent differences in thestress models used. Therefore, this study aimed to evaluate the effects of two immobilization stress protocols on depression/anxiety-likebehaviors in adult male rats.Materials and Methods: Adult Wistar rats were randomly divided into three groups (n=10) comprising: control, immobilization stress-1(45 minutes daily for a period of ten days), and immobilization stress-2 (45 minutes twice a day for a period of ten days). Stress-relatedbehavior was evaluated by means of the open field and forced swim tests. In addition, change in body weight, fasting blood glucose, andserum corticosterone were measured.Results: In the open field test, the percentage of time spent in the central area and mean velocity were significantly lower in theimmobilization stress-1 and immobilization stress-2 groups as compared to the control group (p < 0.05 and p < 0.01, respectively).Movement ratios were lower in both immobilization stress groups than in the control group (p < 0.001 and p < 0.01, respectively). In theforced swim test, the duration of swimming, climbing and immobility behavior in both immobilization stress protocols did not differ fromthe control group. Serum corticosterone levels were higher in the immobilization stress-1 and immobilization stress-2 groups than in thecontrol group (p <0.05), but no overt differences were determined in the percentage change in body weight or the fasting blood glucoselevel between the stress protocol groups and the control group (p > 0.05).Conclusion: We may conclude that immobilization stress-1 and immobilization stress-2 protocols do not cause depression-like behavior inadult male rats. However, anxiety-like behaviors predominated in both stress protocol groups.