Yazar "Şimşek, Murat" seçeneğine göre listele

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    Multifunctional Electrospun Biocompatible Nanofiber Composites from Water Dispersion Blends of Folic Acid Conjugated PVP/Dextran/ODA-MMT Nanocomposites and Their Responses to Vero cells
    (2016) Şimşek, Murat; Rzayev, Zakir M. O.; Bunyatova, Ulviya; Khalilova, Sevda; Türk, Mustafa
    This work presents the fabrication and characterization of novel colloidal multifunctional polymer nanofiber composites (NFCs) from water dispersion blends of the intercalated silicate layered nanocomposites of poly(2-vinyl-N-pyrrolidone)/octadecyl amine-montmorillonite (PVP/ODA-MMT) and Dextran/ODA-MMT as matrix and partner polymer intercalated nanocomposites, as well as their folic acid (FA) conjugated derivatives by reactive electrospinning. The chemical and physical structures, surface morphology and responses to Vero cells of NFCs were investigated. Effects of matrix/partner polymer volume ratios, composition, organoclay and FA on the main important parameters of NFCs were evaluated. Cell culture studies showed that NFCs did not exhibit cytotoxicity significantly and also had a low degree of apoptotic and necrotic effects.
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    PVA Nanofibers Including Biopolymer-grafted Copolymer for Potential Biomedical Applications
    (2018) Şimşek, Murat
    Multifunctional nanofibers were fabricated by electrospinning of polyvinyl alcohol/octadecylamine montmorillonite layered silicate nanocomposite as a matrix polymer and amphiphilic copolymer-g-biopolymer (polylactic acid, PLA) as a biocompatible partner polymer. Crystal structure of the nanofibers significantly changed due to in situ phase separation processing via different chemical and physical interfacial interactions. Relative high thermal stability, high first melting and low crystallinity were observed for the matrix/polymer nanofibers. Nanofibers exhibit low cytotoxicity and necrotic effect for MC3T3-E1 preosteoblast cells.