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    Adipsin as a novel prognostic biomarker for cardiovascular diseases
    (Czech Soc Cardiology & Czech Soc Cardiovascular Surgery, 2022) Askin, Lutfu; Askin, Husna Sengul; Abus, Sabri; Hidayet, Siho
    Increased vascular oxidative stress stimulates the secretion of adipokines from adipocytes. Many clinical studies have demonstrated that plasma adipsin levels are successful in predicting ischemic events. Increased adipsin levels are closely related to all-cause death and morbidity. Therefore, adipsin may be a new biomarker for atherosclerosis. In this review, we aimed to emphasize the association of adipsin with cardiovascular diseases (CVDs) and its beneficial role in the therapeutic field of CVDs.
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    Evaluation of frontal QRS-T angle values in electrocardiography in patients with chronic rhinosinusitis
    (Bmc, 2023) Abus, Sabri; Koparal, Mehtap; Kaya, Hakan; Kapici, Olga Bayar; Tasolar, Mehmet Hakan; Tibilli, Hakan
    BackgroundChronic Rhinosinusitis (CRS) refers to inflammation of the paranasal sinuses and nasal mucosa. Electrocardiographic indicators of ventricular repolarization have been shown to correlate with systemic inflammation parameters. Recently, the frontal QRS-T (fQRS-T) angle has been accepted as a new indicator of ventricular depolarization and repolarization heterogeneity. The (fQRS-T) angle is recommended in predicting the risk of malignant ventricular arrhythmia. In this study, we aimed to evaluate the ventricular arrhythmia potential in patients with chronic rhinosinusitis by examining the relationship between fQRS-T angle on ECG and inflammation markers.MethodsInflammatory markers as well as electrocardiographc (ECG) f(QRS-T) angle, QRS duration, QT interval and corrected QT interval were examined in 54 patients with CRS versus 56 healthy control subjects.ResultsThe f(QRS-T) angle was significantly higher in CRS patients than in healthy controls (p < .001). The neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) and monocyte-to-lymphocyte ratio (MLR) were significantly higher in CRS patients compared to healthy controls (p < .001, for all). Based on correlation analysis, NLR and f(QRS-T) angles were highly correlated (r = .845, p < .001), and according to the results of linear regression analysis, NLR was independently associated with the f(QRS-T) angle (t = 5.149, Beta = 0.595, p = < 0.001).ConclusionBoth f(QRS-T) angle and NLR are significantly increased in CRS patients compared to healthy controls, with increases in NLR also independently associating with increases in f(QRS-T) angle. While the increases in f(QRS-T) angle did not result in clinically alarming absolute values for f(QRS-T), CRS patients might nonetheless be at relatively higher risk for malignant cardiac arrhythmias.