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    Diagnostic and therapeutic approach in newborns with ambiguous genitale with disorder of sex development: consensus report of Turkish Neonatal and Pediatric Endocrinology and Diabetes Societies
    (Turkish Pediatrics Assoc, 2018) Cetinkaya, Merih; Ozen, Samim; Uslu, Sinan; Gonc, Nazli; Acunas, Betul; Akinci, Aysehan; Satar, Mehmet
    Disorders of sex development are defined as conditions in which the chromosomal, gonadal, and anatomic sex is discordant. Patients usually present with atypical appearing genitalia. In the assessment of neonates with disorders of sex development, first, it is important to determine whether this situation requires prompt evaluation, and then the karyotype, hormone levels, and underlying etiology should be determined as soon as possible. All these procedures should be performed in the guidance of a multidisciplinary team in reference centers. As the physical examination of the infant is extremely important, the physcian should suspect and then perform a detailed history and physical examinationi and lastly plan the required laboratory and imaging procedures for the definite diagnosis. It is important not to be hurried in the choice of sex. The aim of this article, which includes the diagnostic and therapeutic approaches in infants with ambiguous genitalia, was to provide a common practice for all pediatricians.
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    Hemolytic disease of the newborn due to minor blood group incompatibility: Sibling cases
    (2019) Aladag Ciftdemir, Nukhet; Aslan, Mustafa Torehan; Tandircioglu, Ayse Umit; Duran, Ridvan; Vatansever Ozbek, Ulfet; Acunas, Betul
    Hemolytic disease of the newborn is mostly caused by the hemolysis of fetal erythrocytes by maternal and placental antibodies. Antigens in this group are Kell, Duffy, Kidd, MNSs and the E, e, C, c found in the Rh system. They are responsible for 3-5% of hemolytic disease of the newborn. In cases of minor blood group incompatibility, clinical picture may vary from subclinical hemolysis findings to active hemolysis and from blood clotting to neonatal jaundice. Here we present two sibling cases with multiple minor blood group (c, Kell, Cw) incompatibilities of whom the first one was diagnosed two years ago as glucose 6-phosphate dehydrogenase deficiency and undergone exchange transfusion and ultimately diagnosed as minor blood group incompatibility after the diagnosis of the second sibling.