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Öğe The CHA2DS2-VASc risk score predicts successful endovascular treatment in patients with acute ischemic stroke(Wiley, 2022) Yasar, Erdogan; Akalin, Yahya; Aktas, Ibrahim; Cakmak, Tolga; Karakus, Yasin; Bayramoglu, AdilObjectives Acute ischemic stroke is a common cause of mortality and morbidity worldwide. Percutaneous endovascular intervention is an important treatment method in ischemic stroke. Endovascular procedure success is associated with the clinical outcome of the patients. The CHA2DS2-VASC score is an important score used to determine the risk of ischemic stroke in patients with atrial fibrillation. In our study, we aimed to evaluate the relationship between procedure success and CHA2DS2-VASC score in patients with acute ischemic stroke who underwent endovascular intervention. Materials and methods A total of 102 consecutive patients who underwent endovascular intervention with acute ischemic stroke were included in the study. The admission CHA2DS2-VASc scores of the patients were recorded. After the procedure, the relationship between the TICI score and the CHA2DS2-VASc score was evaluated. Results CHA2DS2-VASc score was significantly higher in the group that resulted in unsuccessful endovascular intervention (2.78 +/- 1.44, 5.02 +/- 1.77 p < .001). Receiver-operating characteristics analysis revealed the cutoff value of CHA2DS2-VASc score >= 3 as a predictor of unsuccessful intervention with 76,6% sensitivity and 83,3% specificity, positive predictive value 50%, negative predictive value 84,6% (area under the curve [AUC]: 0.827,95% CI: 0.739-0.895, p < .001). In the multivariate analysis; atrial fibrillation ([beta] = 4.201; [CI]: 1.251-14.103, p = .020), CHA2DS2-VASc score ([beta] = 0.053; [CI]: 0.004-0.750, p = .030) were found independent predictors for unsuccessful intervention treatment. Conclusions In our study, we showed that the CHA2DS2-VASc score is associated with the success of endovascular intervention in patients with acute ischemic stroke who underwent percutaneous endovascular treatment.Öğe Otolin-1 as a biomarker for the evaluation of the effectiveness of betahistine treatment for benign paroxysmal positional vertigo(Wolters Kluwer Medknow Publications, 2023) Karaer, Isil Cakmak; Urhan, Ayca; Akalin, YahyaObjectiveBenign paroxysmal positional vertigo (BPPV) is the most common vertigo disorder. Betahistine is the most commonly used drug in the treatment of vertigo, however its effect on the inner ear is not fully known. Otolin-1 is an inner ear-specific glycoprotein that can be identified in peripheral blood. The aim of the study was to determine the effect of treatment of betahistine for BPPV on serum otolin-1 levels.MethodsThirty (30) patients with BPPV and 30 healthy controls were enrolled in the study. Serum otolin-1 levels were measured before and 14 days after perioral (po) betahistine treatment in the BPPV group, whereas otolin-1 level was examined once in controls. The efficacy of treatment was evaluated with Dizziness Handicap Index (DHI) and Visual Analog Scale (VAS) in the BPPV group.ResultsOtolin-1 levels were statistically significantly higher in patients with BPPV than controls. In the BPPV group, serum otolin-1 level was found to be statistically significantly lower after betahistine treatment. There was a statistically significantly difference between pre-treatment and posttreatment groups regarding to both DHI and VAS scores.ConclusionSerum otolin-1 can be used as a biomarker in monitoring the effectiveness of treatment of BPPV with betahistine as well as diagnosis of BPPV.Öğe Prognostic value of glucose fluctuation in patients undergoing thrombolysis or thrombectomy due to acute ischemic stroke(Springer, 2021) Ciplak, Sibel; Adiguzel, Ahmet; Ozturk, Unal; Akalin, YahyaBackground Hyperglycemia during acute ischemic stroke is associated with worse outcomes, and this glucose altitude may persist in the initial days. In this study, we investigate the effect of glucose fluctuations in the first 4 days in patients diagnosed with acute ischemic stroke and who underwent ivr-tPA +/- interventional thrombectomy or only interventional thrombectomy on stroke prognosis. Study was designed bicentered retrospective case series. Patients older than 18 years were included and those suitable for acute treatment, treatment indications, contraindications, and treatment management of hyperglycemia were selected according to the 2018 American Stroke Association guidelines. The effect of fasting glucose values of patients in the first 4 days on admission and 24th hour NIHSS scores, duration of hospitalization, disability, mortality, and prognosis were analyzed. We aimed to demostred the effect of the first 4-day glucose values measured in patients treated in a stroke center on clinical prospect. Results One hundred and seventy-six patients were included in the study. Group 1 included 30 (17%) patients with severe clinical condition (NIHSS at admission >= 16), and Group 2 comprised 146 (83%) patients with moderate and mild clinical condition (NIHSS at admission < 16). The glucose values of Groups 1 and 2 were found as follows: day 1 (admission): 178.7 +/- 10.3 mg/dl and 138.3 +/- 54.9 mg/dl, day 2: 197.7 +/- 99.8 mg/dl and 137.6 +/- 51.8 mg/dl, day 3: 186.1 +/- 97.6 mg/dl and 127.5 +/- 50.0 mg/dl, and day 4: 169.2 +/- 85.0 mg/dl and 126.7 +/- 49.3 mg/dl (p < 0.05). Mortality risk of patients with glucose >= 200 mg/dl was 43.5% on day 1 (p > 0.05), 57.1% on day 2, 68.4% on day 3, and 76.5% on day 4 (p < 0.05). Conclusions The glucose level of patients in severe clinical condition peaked on the second day and that 4 days of resilient severe hyperglycemia is a negative risk factor for sequela and mortality.Öğe Turkish validity and reliability study of public attitudes towards epilepsy(2020) Akturk, Ummuhan; Akalin, YahyaAim: This study was conducted for the purpose of adapting the Public Attitudes Toward Epilepsy Scale (PATE) for the Turkish context and determining its validity and reliability. Material and Methods: This is a methodological research and conducted in a family health centre located in the eastern Turkey between February 2018 and September 2018. In this study, 268 individuals, who were older than 18 years and registered in a Family Health Centre, were reached. Results: The result of the KMO test was determined to be 0.783 and that of Bartlett’s test 1002.772, and both were observed to be significant at a level of p , 0.001. Conclusion: Our study determined that the Turkish version of the PATE has validity and reliability and can be used in Turkish society.
