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Öğe Brain Tumors and Atypical Psychiatric Symptoms: Two Case Presentations(Yerkure Tanitim & Yayincilik Hizmetleri A S, 2018) Akan, Mustafa; Erbay, Lale Gonenir; Erbay, Mehmet Fatih; Unal, Suheyla[Abstract Not Available]Öğe Brain tumors and atypical psychiatric symptoms: two case presentations(Yerkure tanıtım & yayıncılık hızmetlerı a s, cumhuryet cad 48-3b, harbıye, ıstanb, 34367, turkey, 2018) Akan, Mustafa; Erbay, Lale Goneni; Erbay, Mehmet Fatih; Unal, SuheylaÖğe Comparison of substance users under judicial supervision with controls in terms of attention deficit hyperactivity disorder and emotion regulation difficulties(Klinik Psikiyatri Dergisi, 2024) Akan, Mustafa; Ayaz, Nusret; Ugur, KerimObjective: Substance abuse and addiction are reported to be approximately 2 times more common in individuals diagnosed with Attention Deficit Hyperactivity Disorder (ADHD) compared to the general population. Adults with ADHD have been stated to have difficulties in emotion regulation as well as core symptoms of the disease. In this study, it was aimed to evaluate individuals who applied to a university hospital psychiatry clinic probation clinic in terms of attention deficit hyperactivity disorder and emotion regulation difficulties. The hypothesis of the study is that individuals who apply to the outpatient clinic will have higher ADHD symptoms and emotion regulation difficulties than healthy controls. Method: The research was conducted between 18.06.22-30.10.22. 135 male patients diagnosed with substance use disorder and 141 healthy volunteers without any psychiatric disease were included in the study. Adult ADHD selfreport scale (ASRS), Difficulty in Emotion Regulation Scale Short Form (DERS-16), and sociodemographic data form were administered to the participants. Results: The probation group's ASRS total score, attention deficit and hyperactivity/impulsivity subscale scores were found to be statistically significantly higher than the control group (p=0.004, p=0.005, p=0.007, respectively). Also DERS-16 impulse and nonacceptance subscale scores of the probation group were statistically significantly higher than the control group (p=0.001, p=0.015, respectively). Discussion: ADHD and accompanying emotion regulation difficulties may increase the risk of substance use in adults. Considering these clinical features in individuals applying to the probation outpatient clinic may make therapeutic interventions more effective.Öğe The effect of Ramadan fasting on mental health and some hormonal levels in healthy males(Springer, 2023) Akan, Mustafa; Unal, Suheyla; Gonenir Erbay, Lale; Taskapan, Mehmet CagatayBackgroundMillions of Muslims around the world fast during the holy month of Ramadan as a requirement of their religion Islam. Studies have reported varying effects of Ramadan fasting on mental health and various hormones. This study aimed to examine the effects of Ramadan fasting on mental health and plasma Leptin, Ghrelin, Neuropeptide Y (NPY), Growth Hormone levels in healthy individuals, and to evaluate the possible relationship between their hormone values and scale scores. Male healthcare professionals working at a university hospital without any psychiatric disease were included in the study. In the last week before Ramadan and in the first week after Ramadan, participants' blood samples were taken at 8.00 in the morning after 12 h of fasting, taking into account the release pattern and pulsatile release of these hormones in order to measure plasma Leptin, Ghrelin, NPY and Growth Hormone levels. Simultaneously, a sociodemographic data form, the Brief Symptom Inventory (BSI) and the Scale of Dimensions of Interpersonal Relationships were applied to participants.ResultsThe sample of the study included a total of 40 healthcare professionals. Participants' BSI interpersonal sensitivity and phobic anxiety subscales scores and their general severity and positive symptom distress index scores decreased significantly after Ramadan compared to those measured before Ramadan. (p < 0.001, p = 0.020, p = 0.042, p = 0.006 respectively). Also participants' ghrelin levels increased significantly after Ramadan compared to those measured before Ramadan (p < 0.001).ConclusionsThe effects of Ramadan fasting on mental health may be mediated by some psychoneuroendocrine mechanisms. In order to elucidate these mechanisms that mediate the effect of Ramadan fasting on mental health, there is a need for better-structured studies with larger samples and more variables.Öğe Emotional Dysregulation and Temperament-Character Traits in Adolescents With Functional Neurological Symptom Disorder (Conversion Disorder)(Lippincott Williams & Wilkins, 2024) Ucuz, Ilknur; Cicek, Ayla Uzun; Celik, Merve Komurcu; Akan, Mustafa; Kesriklioglu, Esma; Gungor, Serdal; Ozcan, Ozlem OzelThe purpose of this study was to evaluate emotion dysregulation and temperament-character traits in adolescents with functional neurological symptom disorder (FNSD). Forty adolescents with FNSD and 40 healthy adolescents were evaluated by a semiconstructed diagnosis interview, Temperament and Character Inventory (TCI), Difficulties in Emotion Regulation Scale (DERS), Regulation of Emotions Questionnaire (REQ), and Children's Somatization Inventory-24 (CSI-24). The external and internal dysfunctional emotion regulation scores of REQ, all subscales of DERS, except the awareness subscale, and CSI-24 scores were significantly higher in FNSD patients compared with healthy controls. There were significant differences between the groups in terms of harm avoidance and reward dependence subscale scores of TCI. Multiple logistic regression analysis showed that the external dysfunctional emotion regulation strategy, somatization, and reward dependence are significant predictors of FNSD. Our results provide evidence that adolescents with FNSD experience emotional dysregulation and that the differential value of some temperament-character traits in the diagnosis of FNSD.Öğe Frequency and predictors of coronavirus anxiety in psychiatric patients and healthy people and its effect on treatment compliance during the pandemic(2021) Cansel, Nesihan; Ünal, Ahmet; Ekici Onsoz, Saadet; Akan, Mustafa; Gonenir Erbay, Lale; Melez, Sahide Nur IpekCoronavirus-19 has caused anxiety around the world. Although anxiety is inherent in pandemics, it can have serious consequences when it is chronic and disproportionate. It is possible situation affect the vulnerable population with mental illness more. This study compares the frequency and predictors of coronavirus anxiety among psychiatric patients and the healthy group and evaluates its effects on treatment compliance. A cross-sectional study was conducted on 285 psychiatric patients who applied to the psychiatry outpatient clinic and 86 healthy people between 15 July – 30 September 2020. Coronavirus Anxiety Scale was applied with a questionnaire that investigated demographic characteristics, experiences with the pandemic and treatment compliance. Coronavirus anxiety was detected in 8.4% of the patients and 9.3% of the healthy group. 34% of the patients didn’t come to checkups regularly, the most common reason for this was their fear of the pandemic (56.7%). Their anxiety scores were also high. Female gender, comorbid disease and being quarantined were associated with an increased coronavirus anxiety scale score in patients while advanced age, retirement, divorced/widowed, having children, having comorbid disease, being tested for COVID-19 PCR and losing a relative due to COVID-19 increased the score in healthy group. Coronavirus anxiety disrupts the compliance of psychiatric patients with treatment and may cause the disease to exacerbate. Therefore, there is a need to develop special treatment approaches in the follow-up of psychiatric patients.Öğe Gonadotropinler ve gonadal hormonların intihar davranışı üzerine etkileri(İnönü Üniversitesi, 2020) Akan, Mustafa; Erbay, Lale GönenirAmaç: Bu çalışmanın amacı, intihar girişiminde bulunan olguların klinik özelliklerini değerlendirerek gonadotropin ve gonadal hormon seviyelerinin incelenmesi ve bu verilerin intihar düşüncesi ve/veya girişimi olmayan depresyon tanılı hastalar ve sağlıklı kontrollerle ile karşılaştırılmasıdır. Materyal ve Metot: Mart 2019 – Aralık 2019 tarihleri arasında İnönü Üniversitesi Tıp Fakültesi Acil Servisine intihar girişimi nedeniyle başvuran olgularla, SCID ile psikiyatrik görüşme yapılmış, psikopatoloji varlığı belirlenmiştir. Ayrıca olgulara Beck depresyon ölçeği, Beck anksiyete ölçeği, Beck umutsuzluk ölçeği, Barratt dürtüsellik ölçeği ve Columbia intihar şiddetini derecelendirme ölçeği uygulanmış, sosyodemografik veri formu doldurtulmuştur. İntihar girişiminin ardından ilk 24 saat içerisinde sabah 8.00' de olgulardan kan örnekleri alınmış, FSH, LH, östradiol, testosteron, progesteron, kortizol değerleri ölçülmüştür. Çalışmaya dahil edilen intihar girişiminde bulunmuş 33 olgunun verileri; yaş, cinsiyet ve VKİ bakımından eşleştirilmiş diğer iki grup ile kıyaslanmıştır. Bulgular: Çalışmamızda gruplar yaş, cinsiyet, medeni durum, VKİ bakımından birbiri ile benzerdi. Kadın olgular menstruel faz açısından birbiri ile benzerdi. Erkek olgularda gonadotropin ve gonadal hormon düzeyleri gruplar arasında anlamlı farklılık göstermedi. Kortizol düzeyi kadın olgularda üç grup arasında anlamlı farklılık gösterdi, intihar grubunda en düşük olarak ölçüldü. Ayrıca kadın olgularda kortizol düzeyleri ile ölçek puanları arasında negatif korelasyon tespit edildi. Sonuç: Kadınlarda düşük HPA ekseni aktivitesi ile intihar davranışı arasında nedensellik ilişkisi kurmak zordur. İntihar davranışı ve semptomların süresi, bu fenomenle ilişkili olabilecek iki faktördür ve altta yatan mekanizmaları aydınlatmak için daha fazla çalışma yapılması gerekmektedir.Öğe Investigation of the Relationship between Headache and Anxiety during the Late COVID-19 Pandemic Period: A Prospective Case-Control Study(2022) Adıguzel, Ahmet; Akan, Mustafa; Çıplak, SibelObjective: The effects of the COVID-19 pandemic on both the physical and psychological well-being of individuals have not yet been clearly understood. Especially during the early period of the pandemic, the most prevalent psychological effects included fear, preoccupation with health, anxiety, and feeling of loneliness caused by a general sense of uncertainty. The incidence of headache was as high as 70% among the mild COVID-19 cases. Findings from the past coronavirus outbreaks indicated that neuropsychiatric symptoms might cause a significant health burden and adversely affect the patients’ quality of life. The present study aimed to investigate the anxiety-related clinical conditions of the patients diagnosed with primary headache, who presented to the neurology polyclinic during the prolonged pandemic period. Methods: The research was designed as a two-center, prospective case-control study. Patients diagnosed with primary headache, who presented to the neurology outpatient clinic, and healthy volunteers without a primary headache diagnosis were included in the study. Data collection tools included the sociodemographic data form, Headache Impact Test, Coronavirus Anxiety Scale Short Form, and COVID-19 Disease Perception Scale. Results: Data collected from a total of 869 participants, including 408 (47%) patients diagnosed with headache and 461 (53%) healthy volunteers, were investigated. The results of the Headache Impact Test-6 suggested a severe effect on quality of life in 187 participants (45.8%) in the headache group and 73 participants (15.8%) in the Control Group (p=0.001). There was coronavirus anxiety in 59 (14.5%) participants with headache and 8 (1.7%) participants in the Control Group (p=0.001). Furthermore, the rate of coronavirus anxiety in participants that had and did not have COVID-19 was 44 (13.7%) and 22 (4.1%), respectively (p=0.001). Conclusion: The study results revealed that patients with headache and COVID-19 presented with a higher rate of coronavirus anxiety than healthy controls and those not diagnosed with COVID-19. Further studies on larger samples are necessary for investigating the long term neuropsychiatric effects of COVID-19 in individuals.Öğe The Relationship Between Suicide Attempt andGonadotropins, Gonadal Hormones, and Cortisolin Females(2021) Akan, Mustafa; Ayaz, Nusret; Taşkapan, Mehmet Çağatay; Bulut, Nilüfer; Gönenir Erbay, LaleObjective: The aim of this study was to examine the relationship between suicidal behav ior and gonadotropins, gonadal hormones, and cortisol in females.Methods: The study included 3 groups of 23 females each, aged 18-45 years; one groupcomprising those who had attempted suicide, another group of females matched for age,menstrual phase, and body mass index, with depression but no suicidal tendencies, anda control group of 23 healthy females. For all participants, a sociodemographic informa tion form was completed, and the Beck Depression Inventory, the Beck Anxiety Inventory,and the Beck Hopelessness Scale were used. Blood samples were taken at 8 am (in theattempted-suicide group, within 24 hours of the attempt), and follicle-stimulating hor mone, luteinizing hormone, estradiol, testosterone, progesterone, and cortisol levels weremeasured. Results: No statistically significant differences were observed between the groups withrespect to gonadotropin and gonadal hormone levels. There were statistically significantdifferences in the cortisol levels between the attempted suicide and control groups andbetween the depression and control groups (P < .05). The cortisol levels negatively cor related with all scale scores. Conclusion: Studies on suicidal patients should pay more attention to the potential role ofhypocortisolism. More studies with larger samples are needed to investigate the relation ship between gonadotropins, gonadal hormones, and suicidal behavior.
