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Öğe Changing trends in the etiology of liver transplantation in Turkiye: A multicenter study(Kare Publ, 2024) Akarsu, Mesut; Dolu, Suleyman; Harputluoglu, Murat; Yilmaz, Sezai; Akyildiz, Murat; Gencdal, Genco; Polat, Kamil YalcinBackground and aim: This study aimed to identify the indications for liver transplantation (LT) based on underlying etiology and to characterize the patients who underwent LT. Materials and methods: We conducted a multicenter cross-sectional observational study across 11 tertiary centers in Turkiye from 2010 to 2020. The study included 5,080 adult patients. Results: The mean age of patients was 50.3 +/- 15.2 years, with a predominance of female patients (70%). Chronic viral hepatitis (46%) was the leading etiological factor, with Hepatitis B virus infection at 35%, followed by cryptogenic cirrhosis (24%), Hepatitis C virus infection (8%), and alcohol-related liver disease (ALD) (6%). Post-2015, there was a significant increase in both the number of liver transplants and the proportion of living donor liver transplants (p<0.001). A comparative analysis of patient characteristics before and after 2015 showed a significant decline in viral hepatitis-related LT (p<0.001), whereas fatty liver disease-related LT significantly increased (p<0.001). Conclusion: Chronic viral hepatitis continues to be the primary indication for LT in Turkiye. However, the proportions of non-alcoholic fatty liver disease (NAFLD) and ALD-related LT have seen an upward trend over the years.Öğe Identification of risk factors for alcohol relapse in liver transplant patients with alcohol-related liver disease(Elsevier, 2023) Turan, Dilara; Gunsar, Fulya; Harputluoglu, Murat; Kabacam, Gokhan; Gokcan, Hale; Akyildiz, Murat; Akarsu, Mesut[Abstract Not Available]Öğe Liver transplantation in Wilson’s disease: Long-term experience of single center(2019) Agalar, Cihan; Ozbilgin, Mucahit; Unek, Tarkan; Egeli, Tufan; Akarsu, Mesut; Aysal, Anil; Sagol, Ozgul; Ayhan, Ziya; Astarcioglu, IbrahimAim: Liver transplantation (LT) is the most effective treatment method for preventing progressive and lethal complications of Wilson’s disease (WD). Despite the deceased donor liver transplantation (DDLT) and living donor liver transplantation (LDLT) are performed in many centers for WD, a limited number of reports were published, about long-term results. The aim of this study is to share the long-term outcomes of single center.Material and Methods: Patients who underwent LT for the WD, between 1997 and 2017 were included. Patient’s survival data, death causes, neurological symptoms and follow-up data were analyzed retrospectively.Results: Eighteen patients (8DDLT, 10LDLT) with the median age of 17.11±9.88 (6-43) were included. Donor relationship was familial in all LDLT patients. Median follow-up time was 80.57±67.59 (0.23-240.9) months and the median survival time was 173.74±25.13 months. Two patients (11.1%) died in the perioperative period (0-90 days) and totally 3 patients (16.6%) died in the postoperative 0-12 month’s period. The survival rates of the patient’s at 1-, 5- and 10 years were 83.3%, 75% and 67.3%, respectively. After LT, neurological symptoms disappeared in 6 of 7 patients and no improvement was observed in one patient. During follow-up period, chronic rejection was seen in 5 patients, 3 patients were treated with medical procedure and 2 patients died due to chronic rejection.Conclusions: Our findings are consistent with the literature, long-term survival is achieved in patients with no mortality, in the postoperative 0-12 month period and after LT, neurological symptoms are disappeared in most of the patients; according to this data, LT is an effective treatment method for the WD and complications.Keywords: Wilson disease; liver transplantation; long term results; living donor.Öğe Opinions of teachers regarding the ınspection of teachers by school principals ınstead of ınspectors(İnönü Üniversitesi Eğitim Fakültesi Dergisi, 2016) Demirtaş, Hasan; Akarsu, MesutThe purpose of this study is to determine the teachers’ opinions about the fact that the teacher inspections are going to be made by the principals instead of educational inspectors. This study is a qualitative research. The work group of the study consists of 53 pre, primary and secondary school teachers from different branches selected with the maximum variation sampling method and criterion sampling. Data of the study is gathered with a semi-structured forms. As a result of the study it is found that, the teachers don’t regard the educational inspectors’ inspections positively. However; despite some concerns, it is found that they regard the principals’ inspections positively.Öğe REAL LIFE EFFICACY AND TOLERABILITY OF TENOFOVIR ALAFENAMIDE FUMARATE IN PATIENTS WITH HEPATITIS B VIRUS-RELATED CIRRHOSIS AND LIVER TRANSPLANT RECIPIENTS. A-PRELIMINARY RESULT(Wiley, 2021) Yapali, Suna; Gokcan, Hale; Harputluoglu, Murat; Ellik, Zeynep Melekoglu; Akarsu, Mesut; Durak, Serdar; Gokcen, Pinar[Abstract Not Available]Öğe Recommendations for Hepatitis B Immunoglobulin and Antiviral Prophylaxis Against Hepatitis B Recurrence After Liver Transplantation(Aves, 2021) Akarsu, Mesut; Onem, Soner; Turan, Ilker; Adali, Gupse; Akdogan, Meral; Akyildiz, Murat; Aladag, MuratThe combination of hepatitis B immunoglobulin and potent nucleos(t)ide analogs after liver transplantation is considered as the standard of care for prophylaxis against hepatitis B virus recurrence. However, the recommended doses, route of administration, and duration of HBIG administration remain unclear. Moreover, hepatitis B immunoglobulin-free prophylaxis with potent nucleos(t)ide analogs has shown promising disease outcomes in preventing hepatitis B virus recurrence. The current recommendations, produced by the Turkish Association for the Study of the Liver, Acute Liver Failure and Liver Transplantation Special Interest Group, suggest a reduced need for hepatitis B immunoglobulin administration with effective long-term suppression of hepatitis B virus replication using potent nucleos(t)ide analogs after liver transplantation.Öğe Trends and causes of etiology in adult liver transplant patients: multicenter study(Elsevier, 2022) Akarsu, Mesut; Harputluoglu, Murat; Yilmaz, Sezai; Gencdal, Genco; Akyildiz, Murat; Polat, Kamil Yalcin; Dincer, Dinc[Abstract Not Available]
