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Factors affecting the accuracy of 18F-FDG PET/CT in detecting additional tumor foci in breast cancer
(Athens Medical Soc, 2021) Simsek, A.; Kutluturk, K.; Comak, A.; Akatli, A.; Kekilli, E.; Unal, B.
OBJECTIVE To evaluate the effectiveness of F-18-FDG PET/CT for detecting additional tumor foci in breast cancer. MATERIAL-METHOD The data were reviewed retrospectively of 232 women who underwent F-18-FDG PET/CT examination prior to breast cancer surgery between January 2013 and December 2018. RESULTS Additional tumor foci were suspected in 95 cases on F-18-FDG PET/ CT, which were confirmed by histopathological analysis in 81 cases. The sensitivity, specificity, positive predictive value, negative predictive value, and overall accuracy of F-18-FDG PET/CT in detection of additional tumor foci were 77.7%, 79.48%, 66.3%, 87.32%, and 79.23%, respectively. The false negative and false positive rates were 22.22% and 20.51%, respectively. In univariate analysis, only the patient's age was positively associated with accuracy of F-18-FDG PET/CT in detecting additional tumor foci. The accuracy was lower in women aged <= 50 years, with a substantial increase in false positive findings in women in that age group. CONCLUSIONS F-18-FDG PET/CT alone cannot replace conventional diagnostic procedures for evaluating additional tumor foci in breast cancer, as a substantial increase in false positive findings is recorded with this method in women aged <= 50 years old.