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    Application of HPLC to investigate the physicochemical properties and intestinal permeability of Ketoprofen
    (Bentham Science Publishers B.V., 2017) Kaynak M.S.; Çelebier M.; Akgeyik E.; Sahin S.; Altınöz S.
    Introduction: The main objective of this study was to investigate the effect of pH on the solubility and intestinal permeability of ketoprofen by using HPLC. Ketoprofen is a slightly soluble acidic drug, and its solubility in aqueous phase is affected by pH changes dramatically. However, there is no data in the literature to support whether this pH dependent water solubility of ketoprofen will influence its absorption/bioavailability. Method: In this study, the distribution-coefficient (log D) of ketoprofen at various pH values between 4.5 and 7.5 were investigated using HPLC, and then it was made an attempt to correlate the log D values with the intestinal permeability values. For this reason, in vivo intestinal permeability studies were performed at pH 4.5 and pH 7.5. The concentrations of model and reference compounds and also the blank buffers passed though the rat intestine were analyzed by means of a validated HPLC method. Result: A nonlinear relationship was found between the results of in vitro and in vivo studies indicating that the diffusion of ketoprofen was not only related with passive diffusion, but also could be related with active transport. © 2017 Bentham Science Publishers.
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    Preparation and characterization of co-doped tio2 for efficient photocatalytic degradation of ibuprofen
    (Turkish Chemical Society, 2021) Çağlar Yılmaz H.; İlhan C.; Akgeyik E.; Erdemoğlu S.
    Photocatalytic degradation of Ibuprofen (IBU) which is an anti-inflammatory drug was investigated in aqueous solution by Co-doped TiO2 and bare TiO2 synthesized by reflux route. The prepared catalyst powders were fully characterized using X-ray diffraction (XRD), FT-IR spectroscopy, scanning electron microscopy (SEM), BET surface areas, X-ray Fluorescence Spectroscopy (XRF), dynamic light scattering (DLS). Efficiency of photocatalytic activity for synthesized Co-doped and bare TiO2 was evaluated for the degradation of IBU under UV-C and visible irradiation by investigating the effects of cobalt doping percentage, amount of catalyst, irradiation time, initial IBU concentration, pH and also the effect of organic and inorganic matrix. At optimum degradation conditions under UV-C light and visible light, photocatalytic degradation rates were monitored using UV/Vis spectrophotometer, HPLC and Total Organic Carbon (TOC) analysis. The results showed up the degradation of IBU was improved upon Co doping. It was detected that complete removal was achieved within 240 min of irradiation under UV-C and 98% of IBU was decomposed under visible light in 300 min. © 2021, Turkish Chemical Society. All rights reserved.