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Öğe Antioxidant and Antimicrobial activity of Scorzonera papposa collected from Iraq and Turkey(Kahramanmaras Sutcu Imam Univ Rektorlugu, 2020) Mohammed, Falah Saleh; Gunal, Salami; Sabik, Ali Erdem; Akgul, Hasan; Sevindik, MustafaPlants are important natural materials used in complementary medicine. In this study, antioxidant and antimicrobial activities of Scorzonera papposa DC. collected from Duhok (Iraq) and Gaziantep (Turkey) regions were determined. Extracts of aerial parts and roots of the plant with ethanol were obtained. Antioxidant and oxidant potentials were determined by using Rel Assay Diagnostics kits. Antimicrobial activities were tested against bacteria and fungus strains using the agar dilution method. In our study, it was determined that S. papposa has important antioxidant activity. Also, It was found that extracts of plant parts were effective at 50-800 mu g/mL concentrations. As a result, it was determined that S. papposa could be a natural antioxidant and antimicrobial agent that can be used in complementary medicine.Öğe Biochemical changes induced by grape seed extract and low level laser therapy administration during intraoral wound healing in rat liver: an experimental and in silico study(Taylor & Francis Inc, 2018) Erdemli, Mehmet Erman; Salmas, Ramin Ekhteiari; Durdagi, Serdar; Akgul, Hasan; Demirkol, Mehmet; Aksungur, Zeynep; Selamoglu, ZelihaIn the present study, the changes that occur in rat liver tissue as a result of the use of grape seed extract (GSE) and low level laser therapy (LLLT) in intraoral wound (IW) healing are analyzed using biochemical parameters. Diode laser application groups received 8J/cm(2) dose LLLT once a day for 4days (810nm wavelength, continuous mode, 0.25W, 9s). As a result of the biological parameter analysis, it was determined that the oxidative damage caused by the IWs and recovery period on 7th and 14th days could be substantially removed with GSE applications that have antioxidant capacity especially in rat liver tissue. In addition, the active compound of grape seed, catechin is studied in the active site of glycogen synthase kinase 3 (GSK3) target using molecular modeling approaches. Post-processing molecular dynamics (MD) results for catechin is compared with a standard GSK3 inhibitor. MD simulations assisted for better understanding of inhibition mechanism and the crucial amino acids contributing in the ligand binding. These results along with a through free energy analysis of ligands using sophisticated simulations methods are quite striking and it suggests a greater future role for simulation in deciphering complex patterns of molecular mechanism in combination with methods for understanding drug-receptor interactions.Öğe Cortinarius caperatus (Pers.) Fr., A New Record For Turkish Mycobiota(Kastamonu Univ, Orman Fak, 2015) Akata, Ilgaz; Kabaktepe, Sanli; Akgul, HasanIn this study, Cortinarius caperatus (Pers.) Fr. belonging to the family Cortinariaceae was recorded for the first time from Turkey. A short description, ecology, distribution and photographs related to macro and micromorphologies of the species are provided and discussed briefly.Öğe Determination of Mineral Content and Antimicrobial Activity of Natural and Cultural Forms of Pleurotus ostreatus(Kastamonu Univ, Orman Fak, 2016) Sevindik, Mustafa; Akgul, Hasan; Gunal, Selami; Dogan, MuhittinIn this study, Pleurotus ostreatus Jacq. ex. Fr., which are collected from Gaziantep and its culture form that are sold in stores are used as material. Antimicrobial activity of ethanol extract of P. ostreatus is determined by agar dilution method. Also, mineral composition of P. ostreatus are determined in atomic absorption spectrometry by wet digestion method. The aim of the study is to detect and compare both mineral content and antimicrobial activity of natural and cultural forms of P. ostreatus. In the studies, the fungus has been shown to have low antimicrobial activity. It is said to be higher than the natural form of mineral metal levels.Öğe The effects of grapeseed extract and low level laser therapy administration on the liver in experimentally fractured mandible(2017) Erdemli, Mehmet Erman; Akgul, Hasan; Ege, Bilal; Aksungur, Zeynep; Gozukara Bag, Harika; Selamoglu, ZelihaAim: The present study investigated the changes in the liver tissues of rats with experimentally fractured mandible following the use of Grape Extract (GSE) and Low Level Laser Therapy (LLLT) in healing the fracture in dentistry. Materials and Methods: 60 adult male Wistar Albino rats were randomly assigned to 5 main groups (Control, Fractured Mandible (FM), FM + GSE, FM + LLLT, FM + LLLT + GSE), and then these groups were divided into two groups of 7 and 21 days (n = 6). A vertical fracture line passing through the molar teeth was formed in the right mandibles of all subjects except for these in the control group, and the fracture was internally fixed with a four-hole microplate and four micro-screws. Malondialdehyde (MDA), reduced glutathione (GSH), superoxide dismutase (SOD), catalase (CAT) activities were analyzed to determine the changes caused by GSE and LLLT administration in rat liver tissues in fractured mandibles. Results: It was determined that MDA and SOD levels in FM group and GSH and CAT activity levels in FM + GSE group and MDA levels in FM + LLLT group and GSH and CAT levels in FM + GSE + LLLT group increased statistically significantly to the control group on days 7 and 21. Conclusion: Biochemical parameters were investigated on the 7th and the 21st days, and it was determined that the oxidative damage caused by mandibular defects could be eliminated substantially in the rat liver especially with the administration of grapeseed that has antioxidant capacityÖğe The Effects on Oxidative Systems in Liver Tissues of Systemic Ozone Application after Critical Size Hone Defect Surgery in Rat Mandibles(Ars Docendi, 2019) Erdemli, Mehmet Erman; Akgul, Hasan; Selamoglu, ZelihaExamination of the changes that non-toxic doses of antioxidant action ozone used in increasing osteogenic activity by dentists causes on rat liver tissues. The effects of ozone applications that are significant in mandibular bone defect therapies and oral and maxillofacial surgery practice on oxidant / antioxidant system in rat liver tissues are investigated by analyzing malondialdehyde (MDA), reduced glutathione (GSH), superoxide dismutase (SOD), and catalase (CAT) parameters. While there were statistically significant reductions in MDA levels and SOD activities after 15 and 45 days long ozone applications on critical mandibular bone defect induced rat livers, statistically significant increases were observed in GSH levels and CAT activities (P <= 0.05). This is the first study where the effects of ozone therapies used in treatment of mandibular bone defect on liver tissue oxidant / antioxidant system in rats are scrutinized with the analysis of biochemical parameters. It was determined that ozone applications did not have any negative effects on liver tissue oxidant / antioxidant system and concurrently had positive effects on liver antioxidant system and to reveal the biochemical mechanism completely, further studies are needed.Öğe Histomorphometric analysis of the effects of grape seed extract (vitis vinifera) and low-level laser therapy (LLLT) on fracture healing(2020) Ege, Bilal; Aras, Mutan Hamdi; Akgul, Hasan; Kara, Muhammed Isa; Aydemir, Isil; Inan, Sevinc; Taysi, Seyithan; Altundag Kahraman, SevilAim: In this study, we aim to investigate the effects of supplementary Grape Seed Extract (GSE) and Low-Level Laser Therapy (LLLT) on fracture healing, oxidant and anti-oxidant system in experimental mandible fractures.Material and Methods: 48 Wistar Albino rats (adult male, n=48) were used in our study. For all the subjects, a vertical fracture line through molar teeth in right mandibles was created and internally fixed using a four-hole microplate and four micro screws. Firstly, these subjects were randomly divided into 4 main groups (Control, GSE, LLLT, GSE+LLLLT) of 12 animals each, and then these were individually separated into two sub-groups of 7th and 21st days. The number of groups (n=6) was 8 in total. GSE of 300 mg/kg/day were provided to the subjects before they were sacrificed. LLLT of 23 J/cm2 was administered to two different points along with the fracture line at intervals of 48 hours for 7 days in the 7th day sub-groups and for 14 days in the 21st day sub-groups. After the procedure, while biochemical values such as TAS, TOS and OSI are measured; histopathologically it was examined in terms of capillary number and width, inflammatory cell, fibroblast count, collagen fibers, osteoblast count, ossification and mature bone formations.Results: For biochemical analyses, there was statistically significant difference only in TAS values on either the 7th or 21st day for the groups. Histological analyses showed that mandibular fracture healing were significantly better in the GSE and GSE+LLLT groups compared to the control group. The group of only LLLT had limited recovery while the combination of GSE+LLLT was the best for ossification.Conclusions: It is concluded that GSE may be one of the potential methods to accelerate fracture healings in mandibular fractures common in oral and maxillofacial surgery clinic and thus help patients recover in shorter time, and however LLLT can have positive effects on the process of ossification and recovery only when combined with the extract, which may result in better outcomes in clinical use.Öğe Macrofungi determined in Yuvacik Basin (Kocaeli) and its close environs(Kastamonu Univ, Orman Fak, 2018) Akata, Ilgaz; Kabaktepe, Sanli; Sevindik, Mustafa; Akgul, HasanAim of the study: The purpose of this study was to determine the macrofungal diversity of Yuvacik Basin (Kocaeli) and its close environs. Study area: The study area is situated in the east part of Marmara region within the boundaries of Kocaeli and Sakarya provinces of Turkey and it covers 25.759 hectares. The altitude range of region is 150-1610 meters. In addition, the region is in the transition zones of the three different phytogeographic regions containing the Euro-Siberian, the Mediterranean and Irano-Turanian Material and Method: The fungal samples were collected from different localities of Yuvacik Basin and its close environs between 2015 and 2017. During field studies, macroscopic and ecological features of the samples were recorded and they were photographed in their natural habitats and then brought to the labratory. In the labaratory, macroscopic and microscopic characteristics of the samples were examined. After obtaining relevant macroscopic and microscopic data, fungal samples were identified. The identified samples were kept at the herbarium of Ankara University (ANK). Main Results: As a result of field and laboratory studies, a total of 140 species belonging to 44 family and 14 order within the 2 divisions were listed. Among them, 13 species belonged to Ascomycota, 127 to Basidiomycota. Research highlights: In this study, macrofungal diversity of Yuvacik Basin and its close environs were determined. One hundred and thirty-nine species were new for the region. Moreover, edible and poisonous macrofungi species were emphasized.Öğe PHENOLIC CONTENT AND BIOLOGICAL ACTIVITIES OF TRAMETES HIRSUTA(Parlar Scientific Publications (P S P), 2021) Akgul, Hasan; Aslan, Ali; Akata, Ilgaz; Gunal, Selami; Bal, Celal; Baba, HayriNatural mushrooms are one of the important elements of the ecosystem. It has been preferred by people from past to present because of its nutritional and medicinal potentials. In this study, antioxidant, oxidant and antimicrobial potential of Trametes hirsuta (Wulfen) Lloyd has been determined. In addition, phenolic compounds in its fruiting body have been scanned. The antioxidant and oxidant potential was determined using Rel Assay kits. Antimicrobial potential was determined using the agar dilution method. Phenolic contents were scanned on the HPLC device. As a result of the studies, the presence of different levels of Gallic acid, Catechin, 4-Hydroxybenzoic acid and Epicatechin were observed in T. hirsuta. TAS value of T hirsuta was determined 3.466 +/- 0.148 mmol/L, TOS value was 13.482 +/- 0.234 mu mol/L and OSI value was 0.390 +/- 0.018. Antimicrobial activity of T. hirsuta was found to be effective at 100, 200 and 400 mu g/mL concentrations. As a result of the studies, it has been determined that T hirsuta has antioxidant and antimicrobial potential.Öğe Phenolic Content, Antioxidant and Antimicrobial Potential of Endemic Ferulago platycarpa(Gazi Univ, 2020) Mohammed, Falah Saleh; Gunal, Selami; Pehlivan, Mustafa; Dogan, Muhittin; Sevindik, Mustafa; Akgul, HasanIn this study, biological activities and phenolic contents of endemic Ferulago platycarpa Boiss. & Bal. were determined. Within the scope of biological activity, antimicrobial activity, antioxidant and oxidant status of plant extracts were determined. Phenolic contents were determined by using HPLC. Antimicrobial activity was determined against bacteria and fungus strains using the modified agar method. Antioxidant and oxidant status were calculated with Rel Assay kits. Gallic, chlorogenic, cinnamic, syringic acids, epicatechin, catechin and quercetin were found in the plant. It was also determined that the plant has antioxidant and antimicrobial potential. But, because of higher TOS value, it was considered that the plants, which were collected from region suitable for OSI value, could be a natural antioxidant source.
