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    Ascorbic acid and beta-carotene reduce stress-induced oxidative organ damage in rats
    (Taylor & Francis Inc, 2016) Esrefoglu, M.; Akinci, A.; Taslidere, E.; Elbe, H.; Cetin, A.; Ates, B.
    Antioxidants are potential therapeutic agents for reducing stress-induced organ damage. We investigated the effects of ascorbic acid and -carotene on oxidative stress-induced cerebral, cerebellar, cardiac and hepatic damage using microscopy and biochemistry. Male Wistar albino rats were divided into five groups: untreated control, stressed, stressed + saline, stressed + ascorbic acid and stressed + -carotene. The rats in the stressed groups were subjected to starvation, immobilization and cold. The histopathological damage scores for the stressed and stressed + saline groups were higher than those of the control group for all organs examined. The histopathological damage scores and mean tissue malondialdehyde levels for the groups treated with antioxidants were lower than those for the stressed and stressed + saline groups. Mean tissue superoxide dismutase activities for groups that received antioxidants were higher than those for the stressed + saline group for most organs evaluated. Ascorbic acid and -carotene can reduce stress-induced organ damage by both inhibiting lipid oxidation and supporting the cellular antioxidant defense system.
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    Congenital Cutis Laxa Associated with Growth Retardation
    (Univ West Indies Faculty Medical Sciences, 2008) Seyhan, M.; Esrefoglu, M.; Ozcan, H.; Akinci, A.
    Congenital cutis laxa is a rare, clinically and,genetically heterogeneous group of inherited disorders. It is characterized by degenerative changes in elastic fibres and manifests with skin laxity. Here we presented a six-month old boy with congenital cutis laxa associated with growth retardation. We reveal ultrastructural findings and discussed the differential diagnosis.
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    Evaluation of visceral adipose tissue thickness in precocious puberty
    (Verduci Publisher, 2023) Tasolar, S. D.; Sigirci, A.; Ciftci, N.; Cengiz, A.; Dogan, G. M.; Akinci, A.
    - OBJECTIVE: Although there is a relationship between earlier onset of puberty and increased adiposity tissue. Publications in the lit-erature on adiposis in patients with central pre-cocious puberty (CPP) and visceral fat thickness (VFT) have conflicting results. So, in this study, we aimed to evaluate the relationship between sexual maturation and obesity in the development of early puberty and to examine their relationship with pelvic sonographic parameters. PATIENTS AND METHODS: A total of 126 girls [patients - premature thelarche (PT) and CPP - and controls] were included in this study. Anthro-pometric and ultrasonographic evaluations were made by the same pediatric endocrinologist and pediatric radiologist, respectively. Pubertal stages were made according to the Tanner stages. Height, weight, and body mass index were measured as anthropometric measurements, and visceral, sub-cutaneous, and transabdominal fat thicknesses were measured in sonographic evaluation. RESULTS: The study population was divided in-to three groups: 44 healthy subjects to Group 1, 23 patients with PT to Group 2, and 59 patients with CPP to Group 3. When we evaluated the anthropo-metric and ultrasonographic parameters according to pubertal status, significant differences, especial-ly between Group 1 and Group 3, were observed in all data. In the multiple logistic regression analysis, the endometrial thickness (OR = 7.521, p < 0.001) and VFT (OR = 1.530, p < 0.001) were found to be in-dependent predictors of precocious puberty. CONCLUSIONS: It has been found that VFT and endometrial thickness measurements, which are evaluated quickly and accurately by USG, are im-portant predictors of prepubertal precociousness.