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Öğe 3D Micro-CT Analysis of Void and Gap Formation in Curved Root Canals(Aves Press Ltd, 2017) Simsek, Neslihan; Keles, Ali; Ahmetoglu, Fuat; Akinci, Levent; Er, KursatObjective: This study used microcomputed tomography (micro-CT) to compare the volumes of voids and gaps in curved root canals instrumented and filled using various techniques. Methods: Twenty extracted mandibular first molars with two curved mesial root canals were used. Root canals were instrumented using a self-adjusting file (SAF) or Revo-S file system. For standardization, mesiobuccal canals were instrumented with SAF and mesiolingual canals were instrumented with Revo-S in each root. The canals were divided into four experimental groups (n=10 in each). The canals were then filled via cold lateral compaction (CLC) or a thermoplasticized injectable technique (TT) using gutta-percha and AH Plus root canal sealer. The roots were scanned with a micro-CT, and the volumes of the voids and gaps were calculated using three-dimensional (3D) micro-CT images. Data were analyzed using unpaired t- and Kruskal-Wallis tests. A value of P < 0.05 was considered significant. Results: None of the tested techniques provided void-or gap-free fillings. Nevertheless, the SAF showed more gap formation than the Revo-S, and TT showed higher gap formation in all experimental groups. These differences, however, were not statistically significant (p>0.05). Conclusion: The SAF and Revo-S rotary file systems yielded comparable results. No statistically significant difference was found between the results of the various instrumentation and filling techniques.Öğe Determination of trace elements in kidneys, livers and brains of rats with sealer implants by ICP-MS(Taylor & Francis Ltd, 2017) Simsek, Neslihan; Akinci, Levent; Alan, Hilal; Gecor, Orhan; Ozan, UlkuFollowing root canal treatment, sealers may contact periapical tissue. The purpose of this study was to evaluate the systemic toxic effects of epoxy resin-based sealers (AH Plus and Obtuseal). Inductively coupled plasma-mass spectrometry (ICP-MS) was used to measure levels of trace elements (beryllium, magnesium, aluminium, calcium, chromium, arsenic and lead) in the brain, kidney and liver of rats. Twenty sterilized polyethylene tubes were then filled with AH Plus and Obtuseal and implanted into the dorsal subcutaneous tissue of 10 rats; three unoperated animals were used as a control group. After 45 days, the rats were sacrificed by cervical dislocation following anaesthesia, and brains, kidneys and livers were removed from all experimental animals. ICP-MS analysis was used to determine levels of trace elements. Data were analysed using Kruskal-Wallis and Connover post hoc tests. No significant differences were found in aluminium and calcium levels, but brains, kidneys and livers showed significantly higher amounts of magnesium and chromium than the corresponding controls. In the kidney and liver samples, arsenic levels were found to be higher than in the control group. Lead was detected at higher levels only in liver samples from the AH Plus group. Beryllium was not detected in any organ. It was concluded that AH Plus and Obtuseal release minimal quantities of trace elements when in contact with subcutaneous tissue, and further studies are needed to understand the systemic effects of these materials.Öğe Effectiveness of endodontic complexity assessment tool (E-CAT) on the undergraduate students in an endodontic training program and its predictive capability on complications(Wiley, 2023) Hatipoglu, Fatma Pertek; Akinci, LeventIntroductionDental students face a number of challenges when it comes to performing root canal treatments (RCTs). The Endodontic Complexity Assessment Tool (E-CAT) was developed to assist dental practitioners in assessing the complexity of RCTs before beginning treatment. Materials and MethodsThe E-CAT was filled out independently by both the educator and the student. To allow educators to record scores and complexity classes, they transferred their and students' forms to the website . Students began endodontic treatment after learning about the complexity level of the case. The educators were responsible for recording any complications encountered in every case from the outset to 1 month after treatment. ResultsA total of 70 students, 33 in fourth and 37 in fifth-grade, were included in the study. In the cases with higher E-CAT scores, complications such as misdiagnosed, faulty access cavity, furca or coronal third perforation, insufficient root canal instrumentation, working length loss, canal blockage, overpreparation, incomplete root canal filling and overfilling were experienced significantly more often compared to the cases with lower E-CAT scores (p < .05). The number of complications (r = .40, p < .001), treatment sessions (r = .44, p < .001), and teacher support (r = .24, p < .001) positively correlated with E-CAT score (p < .05). ConclusionThe E-CAT is an effective tool for assisting dental students in understanding technical challenges, such as complex root canal anatomy and possible complications during treatment. Educators can also use e-CAT to pre-select clinical cases and standardise student training by offering cases of equal complexity.Öğe Effects of injectable platelet-rich fibrin in experimental periodontitis in rats(Springer, 2021) Aydinyurt, Hacer Sahin; Sancak, Tunahan; Taskin, Cem; Basbugan, Yildiray; Akinci, LeventInjectable platelet-rich fibrin (i-PRF) is an effective biological material that positively contributes to angiogenesis, wound healing, inflammation, regeneration processes, etc. This research aimed to evaluate the effect of i-PRF in rats with experimental periodontitis. Following the development of ligature-induced periodontitis, 24 Wistar albino rats were divided into three groups. Group-1: scaling and root planing (only-SRP); Group-2: SRP + i-PRF; Group-3: only- i-PRF. Heart blood from six donors was used for the i-PRF application. i-PRF was administered as a subgingival injection in the relevant groups on the 1st, 3rd, and 7th days. The tissues were evaluated histopathologically and immunohistochemically. Also, bone structures were examined using micro-CT. According to the data obtained, no statistically significant difference was observed among the groups in terms of bone resorption, inflammation, bone volume, bone levels (mesial/distal), and IL-1 beta, IFN-r, TNF-alpha, VEGF values (p > 0.05). However, bone mineral density was statistically significantly different among the groups (Group3 > Group2 > Group1) (p < 0.0001). Subgingival injection of only-i-PRF showed promising results in periodontitis treatment but contribution to SRP has not been proved according to this study results. The study results suggested that the i-PRF application was as effective as SRP in reducing bone loss, modulating inflammatory process, and effecting cytokines in experimental periodontitis. The significant effect of i-PRF on bone mineral density was the most remarkable result.Öğe Evaluation of the effectiveness of different hemostatics and bioactive materials on the success of vital pulp therapy(Bayrakol Medical Publisher, 2022) Saygin, Aysegul Goze; Unal, Murat; Candan, Merve; Demir, Pinar; Akinci, Levent; Goze, Omer FahrettinAim: The aim of this study was to evaluate the response of the pulp in combination of hemostatic agents with pulp capping materials (PCMs). Material and Methods: A total of 96 rats were used. Two molar teeth of each rat were included and all groups were created of 4 animals. In the occlusal cavities of the teeth, pulp perforations were performed for direct pulp capping. Thereafter, three different agents, which were forming the main groups [Group1: Sterile saline, Group2: Sodium hypochlorite, Group3 :Mecsina Hemostopper] at different periods of time used on pulp perforations and according to PCMs coated on the exposed pulp area, were divided into subgroups (Dycal, Biodentine, Theracal, and MTA Repair HP). Subsequently, all groups were left for two different waiting periods of 7 and 28 days. Half of the rats were sacrificed on the 7th and the remaining half were sacrificed on the 28th day, followed by micro-CT and histological analyzes. Results: When the results of the study were examined, a statistical difference was observed between groups in terms of dentine bridge (DB) formation on the 7th and 28th days, while there was no statistical difference between inflammatory cell response and DB quality. Micro-CT images showed no formation of DB on the 7th day, while DB formation was observed on the 28th day on specimens. Discussion: The combination of MHS and NaOCl may be preferable in order to provide pulp bleeding control in dental applications.Öğe Micro-computed tomography analysis of shaping ability of nickel-titanium instruments activated by continuous rotation or adaptive motion(Wiley, 2024) Urgupluoglu, Sevde Nur; Akinci, Levent; Simsek, NeslihanThis study assessed the ability of Twisted File Adaptive (TFA), TruNatomy (TRN) and VDW.Rotate (VR) instruments activated by continuous rotation (CR) and adaptive motion (AM) to shape curved root canals. Thirty mandibular molars with two separate mesial canals 20 degrees-40 degrees curved were collected and scanned using micro-computed tomography (mu CT). The canals were then randomly assigned into six groups (n = 10): TRN, VR or TFA instruments activated by CR or AM. TRN groups 17.02, 20.04 and 26.04; VR groups 15.04, 20.05 and 25.06; TFA groups were shaped consecutively using 15K-file, 20.04 and 25.06. After they were shaped, the canals were scanned again. The volume of removed dentin, canal transportation and centring ratio were calculated mu CT images. All data were analysed using the Kruskal-Wallis test or one-way analysis of variance (p < 0.05). With both kinematics, the TRN instrument removed the least amount of dentin, the VR-CR and the TFA-AM removed the most (p < 0.05). The transportation and centring ratios among all groups were similar (p > 0.05). The volume of dentin removed, the diameter or design features of the instruments and different kinematics did not affect the centring ratio and the amount of transportation and remained within safe limits. All three instruments activated by either kinematics were found to have similar effectiveness in shaping curved root canals.Öğe Physical properties of MTA, BioAggregate and Biodentine in simulated conditions: A micro-CT analysis(Japanese Soc Dental Materials Devices, 2020) Akinci, Levent; Simsek, Neslihan; Aydinbelge, Hale A.The aim of this study was to evaluate the physical properties of calcium-silicate based cements as retrograde filling in different pH and blood conditions using micro-CT. Eighty-four teeth were obturated and after root-end resection, 3 mm-deep root-end cavity was ultrasonically prepared. The samples were divided into four test groups (n=21). Cements were freshly prepared and analyzed with micro-CT before and after exposed. The test groups were exposed for four days to environments containing acid, alkali, or blood. An acidic pH significantly reduced the volume of all materials after four days and differed from the other environments. Biodentine has the highest percentage of loss in volume and density after treatment in an acidic environment. Porosity formation in the acidic medium was observed in Biodentine amongst all materials. The three-dimensional structures of all materials changed after exposed to an acidic pH, while fewer changes were observed in the structures of materials treated with blood and alkali.
