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    Effect of Interproximal Caries in Primary Molars on Clinical Parameters and Levels of Some Biochemical Markers in Gingival Crevicular Fluid
    (Mary Ann Liebert, Inc, 2020) Duruk, Gulsum; Gurbuz, Taskin; Aksoy, Hulya
    This study aims to investigate the relationship between dental caries and periodontal health by examining the clinical parameters and levels of some biochemical markers in the gingival crevicular fluid (GCF) of the teeth. In 22 children, 22 maxillary primary canine teeth and a pair of primary molars in a total of 38 quadrants were examined. The control group (C) consisted of children who had at least 1 caries-free primary maxillary canine. The test group (T) consisted of children who had a pair of primary molars where the interproximal contact was lost due to the caries in the same quadrant. Their primary molars were restored with compomer. The teeth were evaluated based on clinical values (plaque index, gingival index, and probing depth) and biochemical values in GCF before (C-0, T-0) and after a 6-month treatment (C-1, T-1). While total amounts of interleukin-1 beta and vascular endothelial growth factor in GCF in T-0 were significantly higher than in C-0 (P<0.001), osteocalcin was statistically insignificant (P>0.05). Clinic parameters in T-0 were significantly higher than in C-0 and T-1. Also these parameters in C-0 were higher than in C-1 (P<0.01). Clinical and biochemical parameters in GCF in the teeth with interproximal caries might show symptoms of periodontitis.
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    Oral hygiene in children with epilepsy: Effect of interleukin-1? and VEGF levels in gingival crevicular fluid
    (Polish Dental Soc, 2017) Duruk, Gulsum; Aksoy, Hulya; Gurbuz, Taskin; Laloglu, Esra; Tan, Huseyin
    Background. The biochemical parameters in gingival crevicular fluid (GCF) are affected by some systemic diseases and poor oral hygiene. Objectives. The aim of this study was to evaluate the total amounts of Interleukin-1 beta (IL-1 beta) and vascular endothelial growth factor ( VEGF) in GCF in children with epilepsy. Material and methods. Eighty children with epilepsy in a seizure-free period ( the test group) and 80 healthy children ( the control group) were evaluated. The children with epilepsy were taking valproic acid (VPA), carbamazepine, phenobarbital, and the combinations of these drugs. Gingival index (GI), plaque index (PI), probing depth (PD) and clinical attachment level (CAL) were measured. GCF was collected and its volume was measured. The total amounts of IL-1 beta and VEGF in the GCF were analyzed in the Biochemistry Laboratory at Ataturk University. Results. The biochemical (IL-1 beta and VEGF) and clinical parameters (GI, PI, PD and GCF volume) were significantly higher in children with epilepsy compared to healthy children (p < 0.0001). When the epilepsy patients were divided into groups according to the drug used in this study, there were no significant differences in the GCF levels of IL-1 beta and VEGF among the drug groups. Also, a significant gingival enlargement in the patient population was not recorded. Conclusions. According to these results, it may be suggested that patients need optimal oral care in epilepsy.