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Öğe A case of isolated macrodactyly(2019) An, Isa; Aksoy, MustafaÖğe Clinical features of patients diagnosed with recidivan cutaneous leishmaniasis(2020) An, Isa; Ozturk, Murat; Aksoy, Mustafa; Yentur, Nebiye; Ayhan, Erhan; Eroglu, NaimeAim: Cutaneous leishmaniasis (CL) is a disease with chronic nodulo-ulcerative lesions on the skin that heals with atrophic scars. This study aims to investigate the clinical features of patients admitted to our clinic and diagnosed as recidivan CL.Material and Methods: This retrospective study included 11 patients who were admitted to our skin and venereal diseases clinic between October 2017 and July 2019 and who were diagnosed as recidivan CL by anamnesis, clinical and microscopic examination. Clinical characteristics of the patients such as age, sex, survival in the endemic region, intralesional or systemic antimony therapy and number, location, size and duration of the lesions were recorded.Results: Seven (63.6%) of the 11 patients were male and 4 (36.4%) were female. The mean age of the patients was 13.8 ± 4.04 years. All of the patients in the study had one lesion on their face. The mean lesion duration was 36.27 ± 24.3 months. The mean lesion size was 6.9 ± 3.4 cm. Before the diagnosis, 2 (18.2%) patients received intralesional antimony treatment, 1 patient (9.1%) received systemic antimony treatment, and 8 (72.7%) patients did not receive any treatment.Conclusion: In conclusion, recidivan CL is a rare form of chronic CL. Because parasites are rare in the lesions, the diagnosis is usually delayed and therefore the lesions can cause destruction and deformity. Prospective studies with a large number of patients are needed to better understand the clinical findings of recidivan CL.Öğe Clinical practice guidelines for the diagnosis and treatment of cutaneous leishmaniasis in turkey(Wıley, 111 rıver st, hoboken 07030-5774, nj usa, 2018) Uzun, Soner; Gurel, Mehmet S.; Durdu, Murat; Akyol, Melih; Karaman, Bilge Fettahlioglu; Aksoy, Mustafa; Aytekin, Sema; Borlu, Murat; Dogan, Esra Inan; Dogramaci, Cigdem AsenaBackground Cutaneous leishmaniasis ( CL) is a vector- born parasitic disease characterized by various skin lesions that cause disfiguration if healed spontaneously. Although CL has been endemic for many years in the southern regions of Turkey, an increasing incidence in nonendemic regions is being observed due to returning travelers and, more recently, due to Syrian refugees. Thus far, a limited number of national guidelines have been proposed, but no common Turkish consensus has emerged. Objectives The aim of this study was to develop diagnostic and therapeutic guidelines for the management of CL in Turkey. Methods This guideline is a consensus text prepared by 18 experienced CL specialists who have been working for many years in areas where the disease is endemic. The Delphi method was used to determine expert group consensus. Initially, a comprehensive list of items about CL was identified, and consensus was built from feedback provided by expert participants from the preceding rounds. Results Evidence- based and expert- based recommendations through diagnostic and therapeutic algorithms according to local availability and conditions are outlined. Conclusion Because CL can mimic many other skin diseases, early diagnosis and early treatment are very important to prevent complications and spread of the disease. The fastest and easiest diagnostic method is the leishmanial smear. The most common treatment is the use of local or systemic pentavalent antimony compounds.Öğe Clinical practice guidelines for the diagnosis and treatment of cutaneous leishmaniasis in Turkey(Wiley, 2018) Uzun, Soner; Gurel, Mehmet S.; Durdu, Murat; Akyol, Melih; Karaman, Bilge Fettahlioglu; Aksoy, Mustafa; Aytekin, SemaBackground Cutaneous leishmaniasis ( CL) is a vector- born parasitic disease characterized by various skin lesions that cause disfiguration if healed spontaneously. Although CL has been endemic for many years in the southern regions of Turkey, an increasing incidence in nonendemic regions is being observed due to returning travelers and, more recently, due to Syrian refugees. Thus far, a limited number of national guidelines have been proposed, but no common Turkish consensus has emerged. Objectives The aim of this study was to develop diagnostic and therapeutic guidelines for the management of CL in Turkey. Methods This guideline is a consensus text prepared by 18 experienced CL specialists who have been working for many years in areas where the disease is endemic. The Delphi method was used to determine expert group consensus. Initially, a comprehensive list of items about CL was identified, and consensus was built from feedback provided by expert participants from the preceding rounds. Results Evidence- based and expert- based recommendations through diagnostic and therapeutic algorithms according to local availability and conditions are outlined. Conclusion Because CL can mimic many other skin diseases, early diagnosis and early treatment are very important to prevent complications and spread of the disease. The fastest and easiest diagnostic method is the leishmanial smear. The most common treatment is the use of local or systemic pentavalent antimony compounds.Öğe Determination factors of affecting the risks of non-recovery in cutaneous leishmaniasis patients using binary logistic regression(2018) Aksoy, Mustafa; Yesilova, Abdullah; Yesilova, Yavuz; An, IsaAim: This article aimed to make an assessment by applying the binary logistic regression from the studies reported for cutaneous leishmaniasis patients in the province of Şanlıurfa. Material and Methods: The age and sex, the type, localization, diameter and number of lesions as well as treatments of 8000 cutaneous leishmaniasis patients were retrospectively recorded in this study. The risk of non-recovery for intralesional (IL) and intramuscular (IM) groups according to independent variables were assessed using a binary logistic regression. Results: While there was no difference in non-recuperation risk of IL group between genders, males were 39.4% more likely to recuperate than females among the patients belonging to IM groups. All age groups, non-recuperation risk of children were decreased according to the reference level in IL group. As for the IM treatment, non-recovery risk was considered statistically insignificant. During the disease of the patients receiving both IL and IM treatments, non-recuperation risk of the patients of all-week groups was high according to the reference level. When the head and neck region was taken as reference level, the regions with the highest nonrecuperation risk of the lesion for IL and IM was identified as generalized and trunk, respectively. Conclusions: The treatment success rate is inversely proportional with the lesion duration in both IL and IM treatments. There was decreasing in the success rates of both treatments as a result of an increased in lesion size. Increased lesion diameter results in decreased success rates with both treatments.Öğe The frequency of laryngeal involvement in lipoid proteinosis patients(2019) Aksoy, Mustafa; Yukkaldiran, Ahmet; Yesilova, Yavuz; Demir, Mahmut; Iynen, Ismail; An, Isa; Tanrikulu, OsmanAim: Lipoid proteinosis (LP) is a rare autosomal recessive disorder that occurs with the accumulation of hyaline substance in oral cavity, laryngeal mucosa and skin. The aim of this study was to investigate the incidence of laryngeal involvement in patients with LP which have hoarseness and skin lesions, and the areas of hyaline substance accumulation in the larynx. Material and Methods: In this study, 21 patients who were admitted to our Dermatology outpatient clinic between January 2013 and December 2017 and diagnosed as LP with punch biopsy were evaluated. Laryngeal imaging was performed in otorhinolaryngology clinic, and the frequency of larynx involvement and the areas of hyaline accumulation in the larynx were evaluated. Results: Twenty-one patients with hoarseness and diagnosed by skin biopsy as LP were included in the study. Thickening of the vocal cords in 21 patients (100%); thickening and hypertrophic changes of arytenoids in 13 patients (61.9%); thickening and hypertrophic changes of the interarytenoid area in 10 patients (47.6%); thickeningand hypertrophic changes of epiglottis in 3 (14.3%) patients; hypertrophic changes and thickening of the aryepiglottic fold in 3 patients (14.3%); thickening and hypertrophic changes of ventricular folds in 2 patients (9.5%) were observed. Conclusion: In our study, similar to the data in the literature, the pathological changes were most frequently seen in the vocal cords and the least in the ventricle band, aryepiglottic fold and epiglottis. In order to better understand the laryngeal involvement and the areas of involvement in LP patients, studies with more patients are needed.Öğe Intrarectal negative pressure system in the management of open abdomen with colorectal fistula: A case report(Elsevier Sci Ltd, 2014) Yetisir, Fahri; Salman, A. Ebru; Mamedov, Ruslan; Aksoy, Mustafa; Yalcin, Abdussamet; Kayaalp, CuneytINTRODUCTION: To present the management of open abdomen with colorectal fistula by application of intrarectal negative pressure system (NPS) in addition to abdominal NPS. PRESENTATION OF CASE: Twenty-year old man had a history of injuries by a close-range gunshot to the abdomen eight days ago and he had been treated by bowel repairs, resections, jejunal anastomosis and Hartman's procedure. He was referred to our center after deterioration, evisceration with open abdomen and enteric fistula in septic shock. There were edematous, fibrinous bowels and large multiple fistulas from the edematous rectal stump. APACHE II, Mannheim Peritoneal Index and Bjorck scores were 18, 33 and 3, respectively (expected mortality 100%). After intensive care for 5 days, he was treated by abdominal and intrarectal NPS. NPS repeated for 5 times and the fistula was recovered on day 18 completely. Fascial closure was facilitated with a dynamic abdominal closure system (ABRA) and he was discharged on day 33 uneventfully. There was no herniation and any other problem after 12 months follow-up. DISCUSSION: Management of fistula in OA can be extremely challenging. Floating stoma, fistula VAC, nipple VAC, ring and silo VAC, fistula intubation systems are used for isolation of the enteric effluent from OA. Several biologic dressings such as acellular dermal matrix, pedicled flaps have been used to seal the fistula opening with various success. Resection of the involved enteric loop and a new anastomosis of the intestine is very hard and rarely possible. In all of these reports, usually patients are left to heal with a giant hernia. In contrast to this, there is no hernia in our case during one year follow up period. CONCLUSION: Combination of intra and extra luminal negative pressure systems and ABRA is a safe and successful method to manage open abdomen with colorectal fistula. (C) 2014 The Authors. Published by Elsevier Ltd on behalf of Surgical Associates Ltd.Öğe Neutrophil / Iymphocyte ratio, platelet / Iymphocyte ratio, mean platelet volume and C-reactive protein values in psoriatic arthritis patients(2019) An, Isa; Ucmak, Derya; Ozturk, Murat; Aksoy, Mustafa; Yildiz, Ismail; Ucan, EgemenAim: Studies have shown that neutrophil / lymphocyte ratio (NLR), platelet / lymphocyte ratio(PLR), mean platelet volume(MPV) and C-reactive protein(CRP) are higher in psoriatic arthritis patients than in the control group. In this study, NLR, PLR and MPV values of patients with psoriatic arthritis were calculated and if these parameters were related to CRP levels. Material and Methods: 74 psoriatic arthritis patients and 77 healthy controls without any systemic, infectious and autoimmune diseases were included in the study. Patients were divided into two groups according to their CRP values: normal (0-0.5 mg / dl) and high (> 0.5 mg / dl) Results: NLR, MPV and CRP values in the patient group were significantly higher than the control group. PLR value in the patient group was higher than the control group but the difference between them was not statistically significant. There was a statistically significant relationship between CRP and NLR and MPV values in psoriatic arthritis patients. Conclusion: Since NLR and MPV were significantly higher in psoriatic arthritis patients than in the control group and there was a statistically significant relationship with CRP elevation, it was thought that they were appropriate parameters to show inflammation in patients with psoriatic arthritis.Öğe Retrospective evaluation of clinical and demographic features of 135 patients with lichen planus(2018) An, Isa; Aksoy, Mustafa; Ozturk, Murat; Celik, HakimAim: Lichen planus (LP) is a chronic, inflammatory, papulosquamous skin disease with different clinical features. The incidence varies according to the geographical regions, although it is seen all over the world and all races. In this study, it was aimed to determine the clinical and demographic characteristics of patients with LP in our clinic. Material and Methods: We included 135 patients who applied to our clinic between January 2013 and December 2017 and who were diagnosed as LP by clinical and histopathological examination and who had HbsAg and Anti HCV tests. Patients’ age, sex, clinical variants of disease, mucosal involvement, nail involvement, HbsAg and Anti HCV tests were retrospectively recorded. Results: Of 135 patients included in the study, 68 (50.4%) were males and 67 (49.6%) females. The mean age of the patients ranged from 18 to 65 years, with a mean of 37.8 ± 12.7 years. Oral mucosal involvement was present in 30 (22.2%) patients and nail involvement in 10 (7.4%) patients. Classical LP was present in 111 of the patients (82.2%). HbsAg positivity was found in 3 of the patients (2.2%), but no anti HCV positivity was detected in any of the patients. Conclusion: The clinical and laboratory characteristics of the LP patients in our study were similar to the literature. More research which includes more patients is needed to better understand the clinical and epidemiological characteristics of LP.Öğe The retrospective evaluation of clinical and sociodemographic features of patients with psoriasis(2018) Aksoy, Mustafa; Celik, HakimAim: In this study, we aimed to evaluate the clinical and demographic characteristics of psoriasis patients such as family history, age of onset, clinical type, joint involvement. Material and Methods: 150 patients with psoriasis who were referred to our dermatology clinic between January 2017 and January 2018 were included in the study. Parameters of age, gender, occupation, age of onset, joint or nail involvement, lesion morphology, lesion distribution, disease severity, family history, accompanying diseases, received or ongoing treatments, smoking and alcohol use and body mass index were recorded. The data were analyzed statistically. Results: Of the patients participating in the study, 65 were female and 85 were male. The mean age of onset was 21.65 ± 15.70. Family history was present in 26%, early onset 72%, accompanying diseases 16%, joint involvement 24%, nail involvement 28%, smoking 31.33% and alcohol intake 2.66% of the patients. The most common clinical type was plaque (58.66%), the most common site was scalp/face region (81.33%), and the most commonly used systemic treatment was acitretin (30.66%). Conclusion: Our study results were similar to those of domestic and international studies evaluating the clinical and demographic characteristics of psoriasis. Smoking rates, age of onset and age of admission to hospital were lower in females. Accompanying disease rates were higher in patients with positive family history. We believe that a comprehensive history including alcohol and cigarette use, comorbidities, joint and nail involvement in psoriasis-diagnosed patients will be more useful in terms of the disease progression.
