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    The activities of serum adenosine deaminase and xanthine oxidase enzymes in Behcet's disease
    (Elsevier Science Bv, 2002) Sögüt, S; Aydin, E; Elyas, H; Aksoy, N; Özyurt, H; Totan, Y; Akyol, Ö
    Background: Adenosine deaminase (AD) and xanthine oxidase (XO) are enzymes of purine catabolism that catalyze the conversion of adenosine to inosine, deoxyadenosine to deoxyinosine, hypoxanthine to xanthine and xanthine to Uric acid, respectively. AD is known to be an important enzyme in the maturation and function of T lymphocytes. The aim of this prospective study was to evaluate whether there are changes in serum AD activity as an index of T lymphocyte function in Behcet's disease (BD) which is known as having T cell-mediated immune response. Methods: A total of 32 patients and 26 sex- and age-matched healthy control subjects were analysed for AD and XO activities. The patients with BD were divided into two subgroups: BD with and without eye lesions. Twelve patients with complete BD and four patients with incomplete BD had eye complications. AD and XO activities in serum were measured with spectrophotometric methods. Re vults: There was a remarkable increase in AD activity and moderate increase in XO in patients with BD compared to controls indicating T cell activation and increased maturation. Serum AD activity of complete BD was higher than that of incomplete BD. There was no difference it) XO activity between the subgroups of BD. Significant positive correlation was found between AD and XO in BD, although there was no correlation in control group. Conclusions: The results indicate that increased AD and XO activities may provide an additional benefit for the diagnosis of BD and subtyping of the disease as having eye complication or not and complete and incomplete BD. Further studies are needed to bring to light the exact mechanism of AD and XO activity elevation. (C) 2002 Elsevier Science B.V. All rights reserved.
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    The effects of remifentanil and alfentanil-based total intravenous anesthesia (TIVA) on the endocrine response to abdominal hysterectomy
    (Elsevier Science Inc, 2004) Demirbilek, S; Ganidagli, S; Aksoy, N; Becerik, C; Baysal, Z
    Study Objective: To compare the effects of remifentanil with alfentanil as a part of total intravenous anesthesia (TIVA) on plasma concentrations of cortisol, insulin, and glucose, and hemodynamic responses in patients undergoing abdominal hysterectomy. Design: Randomized, double-blind study. Setting: University hospital. Patients: 24 ASA physical status I female patients scheduled for abdominal hysterectomy. Interventions: Premedicated patients were randomly allocated to receive either remifentanil-propofol (Group R) or a (alfentanil-propofol (Group A). The loading dose of the study drug was administered over 60 seconds (remifentanil l mug kg(-l) or alfentanil 10 mug kg(-l)) followed by a continuous infusion (remifentanil 0.2 mug kg(-l) min(-l) or a fentanil 0.5 mug kg(-l) min). In both groups, propofol was administered until loss of consciousness and maintained with a propofol infusion rate of 100 mug kg(-l) min(-l). After induction of anesthesia, all patients were manually ventilated by mask with O-2-air mixture for 20 minutes. Then rocuronium 0.6 mg kg(-l) was given for tracheal intubation. Measurements: Mean arterial pressure (MAP) and heart rate (HR) were recorded. Plasma concentrations of cortisol, insulin, and glucose were measured during anesthesia and in the recovery room. Main Results: In Group R, MAP and HR were lower after tracheal intubation and skin incision than in Group A (p < 0.05). Plasma cortisol concentrations decreased from baseline values at 20 minutes after induction, after tracheal intubation, and skin incision in Group R (p < 0.001). Plasma concentrations of cortisol and glucose increased from baseline values at 30 minutes after skin incision and continued to increase in both groups (p = 0.001). Plasma concentrations of cortisol, insulin, and glucose did not differ between groups at all sampling times. Conclusion: Remifentanil provided better hemodynamic stability than alfentanil during anesthesia and surgery. However, both remifentanil and alfentanil had similar effects on the stress endocrine response to abdominal hysterectomy. (C) 2004 by Elsevier Inc.