Yazar "Aksoy, Rauf Tuğrul" seçeneğine göre listele

Listeleniyor 1 - 4 / 4
  • Küçük Resim
    Öğe
    The effects of ghrelin on colonic anastomosis healing in rats
    (Clinics, 2013) Ceran Özcan, Canan; Aksoy, Rauf Tuğrul; Gülbahar, Özlem; Öztürk, Figen
    In addition to its roles in the stimulation of growth hormone secretion and the regulation of appetite and metabolism, ghrelin exerts immunomodulatory, anti-inflammatory and antioxidant actions in several organ systems. In this study, we investigated the effects of ghrelin on the healing of experimental colonic anastomoses. METHODS: Wistar rats were randomly divided into two groups (n = 10 in each). A segment of colon was excised, and an end-to-end anastomosis was performed in the distal colon. The Ghrelin Group received 10 ng/kg/day IP ghrelin for seven days postoperatively, whereas the Control Group received an identical volume of saline. On the seventh postoperative day, the anastomotic bursting pressures and hydroxyproline levels were measured, and adhesion formation around the anastomoses was examined. Histopathological analyses were performed to evaluate inflammatory cell infiltration, fibroblast infiltration, collagen density and neovascularization. RESULTS: In the Ghrelin Group, the bursting pressure and hydroxyproline levels were significantly higher than in the Control Group. The adhesion formation scores were lower in the Ghrelin Group than in the Control Group. Although the inflammatory cell infiltration was diminished in the Ghrelin Group, the degrees of fibroblast infiltration, collagen density and neovascularization were not significantly different between the groups. CONCLUSION: Our results indicate that ghrelin improves the healing of colonic anastomoses in rats.
  • Küçük Resim
    Öğe
    The effects of ghrelin on colonic anastomosis healing in rats
    (Clinics, 2013) Özcan, Canan Ceran; Aksoy, Rauf Tuğrul; Gülbahar, Özlem; Öztürk, Figen
    OBJECTIVES: In addition to its roles in the stimulation of growth hormone secretion and the regulation of appetite and metabolism, ghrelin exerts immunomodulatory, anti-inflammatory and antioxidant actions in several organ systems. In this study, we investigated the effects of ghrelin on the healing of experimental colonic anastomoses. METHODS: Wistar rats were randomly divided into two groups (n = 10 in each). A segment of colon was excised, and an end-to-end anastomosis was performed in the distal colon. The Ghrelin Group received 10 ng/kg/day IP ghrelin for seven days postoperatively, whereas the Control Group received an identical volume of saline. On the seventh postoperative day, the anastomotic bursting pressures and hydroxyproline levels were measured, and adhesion formation around the anastomoses was examined. Histopathological analyses were performed to evaluate inflammatory cell infiltration, fibroblast infiltration, collagen density and neovascularization. RESULTS: In the Ghrelin Group, the bursting pressure and hydroxyproline levels were significantly higher than in the Control Group. The adhesion formation scores were lower in the Ghrelin Group than in the Control Group. Although the inflammatory cell infiltration was diminished in the Ghrelin Group, the degrees of fibroblast infiltration, collagen density and neovascularization were not significantly different between the groups. CONCLUSION: Our results indicate that ghrelin improves the healing of colonic anastomoses in rats.
  • Küçük Resim
    Öğe
    Pancreas divisum, pancreaticolithiasis and extraordinary ductal variation in a 14-year-old girl
    (Zeynep Kamil Tıp Bülteni, 2005) Demirbilek, Savaş; Gürünlüoğlu, Kubilay; Yıldırım, Bülent; Akın, Melih; İrşi, Cesim; Aksoy, Rauf Tuğrul; Altınok, Tayfun
    Öz: Pankreas divizyum dorsal ve ventral pankreatik kanalların birleşmemesi sonucu ortaya çıkan pankreasın embriyolojik bir anomalisidir. Çalışmada çok nadir görülen pankreatik kanal anomalisi olan çocuk olgu sunulmuştur. Sunulan olguda dorsal pankreatik kanal ana kanal olup, ventral kanal ikincil kanal olarak dorsal kanalla birleşmektedir. Ana papilla sadece koledok ile devam etmektedir. Kız olgu pankreas divizyununun nadir bir komplikasyonu olan pankreas taşları ile de komplike olmuştur. Olgu birden fazla denenen minör papilla sfinkterotomisine cevap vermemiş ve bu nedenle de açık cerrahi tedavi planlanmıştır. Olguya genişletilmiş uzunlamasına pankreatikojejunostomi (Frey operasyonu) uygulanmış ve cerrahi sonrası son bir yıldır olgunun hiçbir yakınması olmamıştır.
  • Küçük Resim
    Öğe
    Xanthogranulomatous pyelonephritis with unconnected liver lesion
    (Urology, 2011) Karaman, Abdurrahman; Şamdancı, Emine; Doğan, Metin; Aksoy, Rauf Tuğrul; Sığırcı, Ahmet; Demircan, Mehmet
    Xanthogranulomatous pyelonephritis is a chronic renal inflammation characterized by destruction and replacement of its parenchyma with granulomatous tissue. This uncommon condition is rare in children. We report on a 5-month-old male infant with a left renal and hepatic mass detected by ultrasound. The case was preoperatively misdiagnosed as Wilms’ tumor and total nephrectomy and biopsy from liver lesion were performed. The subsequent histopathological findings confirmed the diagnosis of xanthogranulomatous pyelonephritis for renal and liver lesions. Increasing awareness of this disease should lead to the diagnosis being suspected preoperatively even if it is with unconnected tissue lesions.