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  • Küçük Resim
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    Comparison of the effects of mitral regurgitation and pulmonary arterial hypertension on left atrial functions
    (2019) Aksu, Ugur
    Aim: The left atrium (LA) is a cardiac chamber that plays a fundamental role in successful cardiac pumping function and the mortality is more frequent in patients withLA dysfunction. Both of left cardiac pathologies such as mitral regurgitation (MR) and right cardiac pathologies such as pulmonary hypertension (PHT) may cause structural and functional alteration in LA. In the present study, we examined the effects of PHT and MR on LA functions by making use of deformation parameters. Material and Methods: 58 patients followed up with diagnoses of MR (32) and PHT (28) and healthy subjects (28) having the demographical characteristics similar to those of patients were involved in the present study. The deteriorations of LAfunctions of patients, changes of affected parameters among the disease groups, and the clinical effects of these changes were examined. Results: 88 patients were involved in the present study. The mean age was 38.7±4.5 years, and 34% of the participants were male. AlthoughLA functions were found to be deteriorated in both diseases when compared to the control group in univariate analysis, the difference was found only in deformation analyses (p:0.02). In MR group, LA functions were determined to be lower than both of PHT and control group. In correlation analysis, both of the diseases were found to be significantly related with LAS and LASR. Conclusions: In the present study, we showed that both of the diseases may affect the LA functions at various levels and, when compared to conventional methods,LAS and LASR parameters can provide more accurate information about the severity of both diseases.
  • Küçük Resim
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    Elevated serum uric acid levels are associated with increased risk score and MACE development in patients with STEMI
    (2019) Aksu, Ugur; Gulcu, Oktay
    Aim: Although the relationship between changes in serum uric acid (UA) levels and adverse events in ST segment elevation myocardial infarction (STEMI) patients is well known, the effect of an increase in UA levels on risk scores or major adverse cardiovascular event (MACE) development are not well established. In this study, we investigated the effects of ordinal changes in serum UA levels on adverse events and risk scores in STEMI patients. Material and Methods: The patients presenting with a diagnosis of STEMI and undergoing coronary angiography were included in the study. The patients were divided into seven groups evenly according to baseline UA levels and the effects of changes in UA levels on risk score and MACE were investigated. Results: A total 1200 STEMI patients was included in the study. The mean age of the patients was 62 years and 72% of them were males. While both Syntax score-II (SS-2) and Cadillac scores (CS) were lower among Group-1 and Group-4; SS-2, CS and development of MACE were markedly increased with an increase in UA levels. Conclusions: The UA levels in STEMI patients can be guiding for the clinician regarding the development of adverse event and patient-based intensive approaches should be considered in the patients with higher UA levels.
  • Küçük Resim
    Öğe
    The relationship between P wave dispersion and left atrial volume index in patients with metabolic syndrome
    (2019) Aksu, Ugur
    Aim: The incidence of cardiovascular diseases has increased in patients with metabolic syndrome(MS)and left atrial functions also begin to deteriorate from the early period. This effect could be demonstrated by both ECG and Echocardiography. In this study, we investigated the relationship between left atrium volume index (LAVi), which is a sensitive indicator of left atrial dysfunction, and p-wave dispersion (Pd) in patients with MS. Material and Methods: Patients with MS were included in the study. Baseline ECG and transthoracic echocardiography (TTE) measurements were performed and the correlation between the Pd and LAVi was investigated. Results: 180 patients were included in the study. The median age of the study population was45(36-57) and 64% was male. In correlation analysis, there was a good correlation between Pd and LAVi(r:0.73 and p<0.001) and moderate correlation between Pd and systolic pulmonary artery pressure(r: 0.32 and p:0.023).In regression analysis, we found a linear correlation between Pd and LAVi(OR:4.3, 95%CI:3.2-8.1, p:0.011) Conclusions: Left atrial function was deteriorated in MS. This affects could be detected in surface ECG or TTE. In patients with MS, increase in Pd may be a guide for left atrial dysfunction and echocardiographic examination could be a reasonable approach to these patients.