Yazar "Aktas, Ibrahim" seçeneğine göre listele

Listeleniyor 1 - 4 / 4
  • Küçük Resim Yok
    Öğe
    Altered cardiac autonomic function after recovery from COVID-19
    (Wiley, 2022) Kurtoglu, Ertugrul; Afsin, Abdulmecit; Aktas, Ibrahim; Akturk, Erdal; Kutlusoy, Ergun; Cagasar, Ozlem
    Background Autonomic dysfunction may occur during the acute phase of COVID-19. Heart rate variability (HRV) is a useful tool for the assessment of cardiac sympathetic and parasympathetic balance. We aimed to evaluate cardiac autonomic function by using HRV in subjects after recovery from COVID-19 who had previously symptomatic and were followed outpatiently. Methods The study group composed of 50 subjects with a confirmed history of COVID-19 and the control group composed of 50 healthy subjects without a history of COVID-19 and vaccination. All the study participants underwent 2-dimensional, pulsed- and tissue-Doppler echocardiographic examinations and 24-hour Holter monitoring for HRV analysis. Results Time domain parameters of SDNN, SDANN, SDNNi, RMSSD, pNN50, and HRV triangular index were all decreased in the study group when compared with the control group. Frequency domain parameters of TP, VLF, LF, HF, and HFnu were also decreased in the study group in comparison with the control group. LFnu was similar between groups. Nonlinear parameters of HRV including alpha(1) and alpha(2) decreased in the study group. By contrast, Lmax, Lmean, DET, REC, and Shannon entropy increased in the study population. Approximate and sample entropies also enhanced in the study group. Conclusions The present study showed that all three domain HRV significantly altered in patients after recovery from COVID-19 indicating some degree of dysfunction in cardiac autonomic nervous system. HRV may be a useful tool for the detection of preclinical autonomic dysfunction in this group of patients.
  • Küçük Resim Yok
    Öğe
    The CHA2DS2-VASc risk score predicts successful endovascular treatment in patients with acute ischemic stroke
    (Wiley, 2022) Yasar, Erdogan; Akalin, Yahya; Aktas, Ibrahim; Cakmak, Tolga; Karakus, Yasin; Bayramoglu, Adil
    Objectives Acute ischemic stroke is a common cause of mortality and morbidity worldwide. Percutaneous endovascular intervention is an important treatment method in ischemic stroke. Endovascular procedure success is associated with the clinical outcome of the patients. The CHA2DS2-VASC score is an important score used to determine the risk of ischemic stroke in patients with atrial fibrillation. In our study, we aimed to evaluate the relationship between procedure success and CHA2DS2-VASC score in patients with acute ischemic stroke who underwent endovascular intervention. Materials and methods A total of 102 consecutive patients who underwent endovascular intervention with acute ischemic stroke were included in the study. The admission CHA2DS2-VASc scores of the patients were recorded. After the procedure, the relationship between the TICI score and the CHA2DS2-VASc score was evaluated. Results CHA2DS2-VASc score was significantly higher in the group that resulted in unsuccessful endovascular intervention (2.78 +/- 1.44, 5.02 +/- 1.77 p < .001). Receiver-operating characteristics analysis revealed the cutoff value of CHA2DS2-VASc score >= 3 as a predictor of unsuccessful intervention with 76,6% sensitivity and 83,3% specificity, positive predictive value 50%, negative predictive value 84,6% (area under the curve [AUC]: 0.827,95% CI: 0.739-0.895, p < .001). In the multivariate analysis; atrial fibrillation ([beta] = 4.201; [CI]: 1.251-14.103, p = .020), CHA2DS2-VASc score ([beta] = 0.053; [CI]: 0.004-0.750, p = .030) were found independent predictors for unsuccessful intervention treatment. Conclusions In our study, we showed that the CHA2DS2-VASc score is associated with the success of endovascular intervention in patients with acute ischemic stroke who underwent percutaneous endovascular treatment.
  • Küçük Resim
    Öğe
    The localization of ERα and ERß in rat testis and epididymis
    (2020) Gur, Fatih Mehmet; Aktas, Ibrahim
    Aim: It is an indisputable fact that estrogens are essential for the normal functioning of the male reproductive system. Although there are many studies investigating the localization of estrogen receptor α (ERα) and estrogen receptor ß (ERß) in the testis and epididymis, there is no consensus between the results of these studies. Therefore, in this study, it was aimed to investigate the ERα and ERß expression pattern in testis and epididymis using immunohistochemical methods. Material and Methods: The testis and epididymis tissues removed from 3 adult rats after anesthetized with ether. Then the tissues fixed in Bouin's fixative. The tissues embedded in paraffin were cut 5 µm thickness with microtome and stained with immunohistochemical methods. Results: In the testis, ERα-positive immunostaining was observed in the nuclei of peritubular myoid cells and in the cytoplasm of Leydig cells. The germ cells other than spermatogonium and spermatid were ERα-negative. ERβ-positive immunoreaction was detected in the nuclei of spermatogonia, peritubular myoid cells and Leydig cells. The cells in which ERα and ERβ positive immunostaining were seen most intensively were spermatogonia. ER (α and ß) positive immunostaining in the epididymis was observed in epithelial cells and interstitial stromal cells. Although most of the epithelial cells (principal, basal, apical) were ERα and ER β positive staining, others were negative.Conclusion: The results obtained in this study showed that ERα and ERß are localized in somatic and germ cells in the testis and epithelial and stromal cells in the epididymis. In this study, it was observed that ERα and ERß staining intensity in spermatogoniums was higher than other cells. This result can be interpreted that estrogens perform their effects on the testis mainly through spermatogonia. The presence of ER (α and ß) in testis and epididymis, support the view that estrogens play an important role in the development and maintenance of male reproductive functions and fertility.
  • Küçük Resim
    Öğe
    The treatment effect of silymarin on heart damage in rats
    (2020) Aktas, Ibrahim; Ozgocmen, Meltem
    Aim: In this article, we evaluated the possible cardiac protective effects of silymarin on valproic acid-induced heart injury by histological and biochemical parameters in rat heart.Material and Methods: The experiment was performed with 21 Sprague Dawley male rats. Rats were divided into three groups: group 1; control, group 2; valproic acid, group 3; valproic acid + silymarin. The groups received valproic acid 500 mg/kg/day per os (p.o.) and silymarin 100 mg/kg/day p.o. for 14 days except the control group.Results: Silymarin treatment decreased the levels of lactate dehydrogenase, creatine kinase isoenzyme MB, alanine aminotransferase and aspartate aminotransferase significantly (p 0.05). In addition, the increase of malondialdehyde level and decrease of glutathione level by valproic acid were significantly suppressed by silymarin in heart tissue (p 0.05). Histologically, the amount of heart injury was significantly lower in valproic acid + silymarin group and histopathological findings were decreased in valproic acid + silymarin group compared to valproic acid group (p 0.005).Conclusion: In this study, it was observed that silymarin has a curative effect on valproic acid induced heart damage. In this sense, we believe that our study will be usefull for other studies which will be study with silymarin and valproic acid.