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    Antioxidant Effect of a Dihydropyridine Calcium Antagonist Nitrendipine in Streptozotocin-Induced Diabetes
    (Pleiades Publishing Inc, 2020) Unuvar, S.; Gursoy, S.; Berk, A.; Kaymaz, B.; Ilhan, N.; Aktay, G.
    The present study aims to evaluate the effects of a dihydropyridine (DHP) derivative calcium channel antagonist nitrendipine (NIT) on lipid peroxidation (LPO), liver enzyme markers, glucose and lipid profile in rats with streptozotocin (STZ)-induced diabetes. A total of 24 female Sprague Dawley rats were classified into three groups as controls, STZ and STZ+NIT. Fasting blood glucose (FBG), triglyceride (TG), total cholesterol (TC) and high-density lipoprotein (HDL) levels, and alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activity were measured seven weeks after the administration of STZ and NIT. The levels of thiobarbituric acid substance (TBARS), glutathione (GSH) and total thiol content (T-SH), as well as the levels of nitric oxide and metabolites (NO, nitrate, nitrite), were evaluated to assess the level of lipid peroxidation in liver, brain, kidney, heart and eye tissues. STZ significantly increased FBG levels, ALT and AST activity, and TBARS levels (p < 0.001, for all), and significantly reduced the levels of GSH and T-SH (p < 0.05), as well as total NO and nitrate (p < 0.001). STZ triggered LPO in tissues, while simultaneously causing a marked decrease in endogenous antioxidant content. NIT administration protect the kidney (p < 0.05), heart (p < 0.01), brain (p < 0.001) and eye (p < 0.05) tissues from LPO, and also normalized the elevated FBG levels and the activity of ALT and AST (p < 0.001, for all). NIT further stimulated GSH and T-SH production, particularly in the liver, kidney and heart tissues. The results of the present study suggest that NIT shows hypoglycemic activity in STZ-DM rats by increasing insulin sensitivity in the peripheral target tissues.
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    Antioxidant Effect of a Dihydropyridine Calcium Antagonist Nitrendipine in Streptozotocin-Induced Diabetes (vol 57, pg 126, 2020)
    (Pleiades Publishing Inc, 2021) Unuvar, S.; Gursoy, S.; Berk, A.; Kaymaz, B.; Ilhan, N.; Aktay, G.
    [Abstract Not Available]
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    The antioxidant effects of dry apricot in the various tissues of rats with induced cold restraint stress
    (Taylor & Francis Ltd, 2012) Uguralp, S.; Ozturk, F.; Aktay, G.; Cetin, A.; Gursoy, S.
    alpha-Tocopherol and beta-carotene are the best known and most widely used natural antioxidant substances. Apricot contains beta-carotene, tocopherols and flavonoids. This experimental study was designed to investigate the protective effect of Malatya kabashi apricot in stress-induced injury in various tissues of rats. In total, 32 male Wistar albino rats were divided into four groups: control, apricot, stress and apricot-stress groups. Apricot was administrated to rats by gavage for 10 days in the apricot and apricot-stress groups. Then rats were kept at 4 degrees C for 4 h in stress and apricot-stress groups. The rats were killed at the end of the experiment for biochemical and histological examinations. This study shows apricot supplementation decreased oxidative stress injury in both the stomach and intestine.
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    The antioxidant properties and the COX-inhibitory effects of some 6-(a-aminobenzyl) thiazolo [3,2-b]-1,2,4-triazole-5-ol compounds
    (Blackwell Publishing, 2008) Aktay, G.; Tozkoparan, B.; Ertan, M.
    [Abstract Not Available]
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    Evaluation of the wound healing activity of Buxus sempervirens L. and Centaurium erythraea (L.) Rafn. by using in vivo and in vitro Methods
    (Georg Thieme Verlag Kg, 2013) Akkol, Kupeli E.; Suntar, I; Keles, H.; Aktay, G.
    [Abstract Not Available]
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    Investigating biological activity potential of Plantago lanceolata L. In healing of skin wounds by a preclinical research
    (Turkish Pharmacists Association, 2016) Kuranel, E.; Küpeli Akkol, E.; Süntar, I.; Gürsoy, Ş.; Keleş, H.; Aktay, G.
    Plantago lanceolata L. has been used for wound healing in Turkish traditional medicine. In the present study the wound healing and anti-inflammatory effects of the aqueous and methanol extract of P. lanceolata were investigated. In vivo excision and incision wound models were applied on mice and rats for the evaluation of the wound healing effect of P. lanceolata. Inhibitory effect of the extracts on acetic acid-induced increase in capillary permeability was assessed by using Whittle Method. Moreover, the levels of thiobarbituric acid reactive substances (TBARs), glutathione (GSH), total thiols (TSH), hydroxyproline (HP), and tissue trace elements (Zn+2 and Cu+2) were analysed. The aqueous extract of P. lanceolata was found to have wound healing activity in both incision and excision wound models. The results obtained from histopathological analysis also supported the data. Significant anti-inflammatory activity was also detected for both extracts. P. lanceolata significantly reduced the levels of TBARs which is one of the indicators of oxidative stress on the wounded tissue and increased the levels of GSH, TSH and HP. Additionally, P. lanceolata was found to have capacity to increase the levels of tissue Zn+2and Cu+2, both of which are important indicators in the process of wound healing and collagen synthesis. The results indicated that P. lanceolata which is used in the treatment of wounds in addition to many illnesses in traditional medicine and is rich in terms of flavanoids has a powerful antioxidant effect and so it has a positive assistance in healing process. More advanced studies are needed to illuminate the mechanism accurately. © 2016, Turkish Pharmacists Association. All rights reserved.