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Öğe Changing trends in the etiology of liver transplantation in Turkiye: A multicenter study(Kare Publ, 2024) Akarsu, Mesut; Dolu, Suleyman; Harputluoglu, Murat; Yilmaz, Sezai; Akyildiz, Murat; Gencdal, Genco; Polat, Kamil YalcinBackground and aim: This study aimed to identify the indications for liver transplantation (LT) based on underlying etiology and to characterize the patients who underwent LT. Materials and methods: We conducted a multicenter cross-sectional observational study across 11 tertiary centers in Turkiye from 2010 to 2020. The study included 5,080 adult patients. Results: The mean age of patients was 50.3 +/- 15.2 years, with a predominance of female patients (70%). Chronic viral hepatitis (46%) was the leading etiological factor, with Hepatitis B virus infection at 35%, followed by cryptogenic cirrhosis (24%), Hepatitis C virus infection (8%), and alcohol-related liver disease (ALD) (6%). Post-2015, there was a significant increase in both the number of liver transplants and the proportion of living donor liver transplants (p<0.001). A comparative analysis of patient characteristics before and after 2015 showed a significant decline in viral hepatitis-related LT (p<0.001), whereas fatty liver disease-related LT significantly increased (p<0.001). Conclusion: Chronic viral hepatitis continues to be the primary indication for LT in Turkiye. However, the proportions of non-alcoholic fatty liver disease (NAFLD) and ALD-related LT have seen an upward trend over the years.Öğe The effect of clinicopathologic findings of hepatocellular carcinoma on posttransplant survival: a multcenter cohort from TASL liver transplantation special interest group(Elsevier, 2022) Akyildiz, Murat; Gencdal, Genco; Ince, Volkan; Harputluoglu, Muhsin Murat; Bozkurt, Birkan; Zeytunlu, Murat; Kilic, Murat[Abstract Not Available]Öğe Identification of risk factors for alcohol relapse in liver transplant patients with alcohol-related liver disease(Elsevier, 2023) Turan, Dilara; Gunsar, Fulya; Harputluoglu, Murat; Kabacam, Gokhan; Gokcan, Hale; Akyildiz, Murat; Akarsu, Mesut[Abstract Not Available]Öğe Recommendations for Hepatitis B Immunoglobulin and Antiviral Prophylaxis Against Hepatitis B Recurrence After Liver Transplantation(Aves, 2021) Akarsu, Mesut; Onem, Soner; Turan, Ilker; Adali, Gupse; Akdogan, Meral; Akyildiz, Murat; Aladag, MuratThe combination of hepatitis B immunoglobulin and potent nucleos(t)ide analogs after liver transplantation is considered as the standard of care for prophylaxis against hepatitis B virus recurrence. However, the recommended doses, route of administration, and duration of HBIG administration remain unclear. Moreover, hepatitis B immunoglobulin-free prophylaxis with potent nucleos(t)ide analogs has shown promising disease outcomes in preventing hepatitis B virus recurrence. The current recommendations, produced by the Turkish Association for the Study of the Liver, Acute Liver Failure and Liver Transplantation Special Interest Group, suggest a reduced need for hepatitis B immunoglobulin administration with effective long-term suppression of hepatitis B virus replication using potent nucleos(t)ide analogs after liver transplantation.Öğe Right-lobe Liver Transplant From Donors With Gilbert Syndrome(Baskent Univ, 2012) Demirbas, Tolga; Piskin, Turgut; Dayangac, Murat; Yaprak, Onur; Akyildiz, Murat; Tokat, Yaman; Yuzer, YildirayObjectives: Donor safety is one of the most important aspects of living-donor liver transplant. The preoperative evaluation of candidates for such transplants essentially starts with serologic and biochemical analyses. However, some potential liver donors with normal liver function test results may have isolated mild hyperbilirubinemia (serum indirect bilirubin level > 20.5 mu mol/L [1.2 mg/dL]). Gilbert syndrome is an autosomal recessive condition that is a common cause of nonhemolytic unconjugated hyperbilirubinemia, and its prevalence is 3% to 10% in the healthy US population. Mild hyperbilirubinemia episodes are expected in people with Gilbert syndrome when they are exposed to physical stress, such as operative intervention or low energy intake. The liver morphologic findings of these individuals are normal; however, there is a debate on the use of people with Gilbert syndrome as living-liver donors. The purpose of this study was to assess the results of right-lobe living-donor hepatectomy of liver donors with Gilbert syndrome. Materials and Methods: Between 2004 and 2010, two hundred twenty-five living-donor liver transplants using right-lobe grafts were performed in our hospital. Donors with Gilbert syndrome were defined as those whose serum bilirubin level was greater than 20.5 mu mol/L (1.2 mg/dL). Six of 225 right-lobe living-donor liver transplants were performed using donors with Gilbert syndrome. Results: The median follow-up after transplant was 34 months (range, 18 to 51 mo). One week after the operation, the median bilirubin level for rightlobe liver donors was 34.5 mu mol/L (2.02 mg/dL) (range, 17.1 to 51.3 mu mol/L [1 to 3 mg/dL]), and the median prothrombin time (international normalized ratio) was 1.36 (range, 1.1 to 1.7). The median bilirubin level of the donors after 6 months was 29 mu mol/L (1.7 mg/dL) (range, 20.5 to 41 mu mol/L [1.2 to 2.4 mg/dL]). Conclusions: Living-donor liver transplant from Gilbert syndrome donors can be safely performed.Öğe Trends and causes of etiology in adult liver transplant patients: multicenter study(Elsevier, 2022) Akarsu, Mesut; Harputluoglu, Murat; Yilmaz, Sezai; Gencdal, Genco; Akyildiz, Murat; Polat, Kamil Yalcin; Dincer, Dinc[Abstract Not Available]
