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    A new PEPPSI type N-heterocyclic carbene palladium(II) complexes and its efficiency as a catalyst for Mizoroki-Heck cross-coupling reactions in water : Synthesis, Characterization and their antimicrobial and Cytotoxic activities
    (Elsevier, 2021) Mnasri, Aziza; Al-Ayed, Abdullah Sulaiman; Ozdeir, Ismail; Gurbuz, Nevin; Naceur, Hamdi
    A series of novel benzimidazolium salts 2 and their new air and moisture stable PEPPSI type N-heterocyclic carbene palladium(II) complexes (PEPPSI: pyridine-enhanced pre-catalyst preparation, stabilisation, and initiation), were synthesized and characterized by means of H-1 and C-13{1H} NMR, FTIR spectroscopic methods and elemental analysis was employed to catalyze the Mizoroki-Heck cross-coupling reactions of aryl bromides with styrene in water. To the best of our knowledge, this is the first report where a Pd-PEPPSI catalyst was successfully employed in aqueous-phase Mizoroki-Heck reaction. Good to excellent yields of cross-coupling products were obtained with a range of representative aryl bromides under relatively mild conditions. Moreever the antimicrobial activity of the PEPPSI type N-heterocyclic carbene palladium(II) complexes 3a-e varies with the nature of the ligands. Also, the IC50 values of both, complexes (3a-e) have been determined. In addition, the new PEPPSI type N-heterocyclic carbene palladium(II) complexes were screened for their cytotoxic activities. Complex 3b exhibited the highest antitumor effect with IC50 values 0.63 mu g/mL and against MCF-7. (C) 2021 Elsevier B.V. All rights reserved.
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    Preparation and characterization of PEPPSI-palladium N-heterocyclic carbene complexes using benzimidazolium salts catalyzed Suzuki-Miyaura cross coupling reaction and their antitumor and antimicrobial activities
    (Taylor & Francis Ltd, 2019) Boubakri, Lamia; Dridi, Khaireddine; Al-Ayed, Abdullah Sulaiman; Ozdemir, Ismail; Yasar, Sedat; Hamdi, Naceur
    New palladium complexes were efficiently synthesized from the reaction of benzimidazolium salts 2a-e, potassium carbonate (K2CO3) and palladium chloride (PdCl2) in pyridine (for 3a-e). The catalytic activity of these complexes in a catalytic system including palladium complexes and K2CO3 in DMF-H2O was evaluated in Suzuki-Miyaura cross-coupling reactions of aryl bromides and chlorides with phenylboronic acid. Our novel complexes show excellent catalytic activities with high turnover numbers (TON) and high turnover frequencies (TOF) (e.g. for the Suzuki-Miyaura reaction: TON up to 370 and TOF up to 123.3 h(-1)). Both benzimidazolium salts 2a-e and complexes 3 have been characterized using spectroscopic data and elemental analysis. The antimicrobial activity of the N-heterocyclic carbene palladium complexes 3a-e varies with the nature of the ligands. Also, the IC50 values of both, complexes (3a-e) and benzimidazoles 2a-e, have been determined. In addition, the new palladium complexes were screened for their antitumor activity. Complexes 3e and 3d exhibited the highest antitumor effect with IC50 values 6.85 mu g/mL against MCF-7 and 10.75 mu g/mL against T47D, respectively. [GRAPHICS] .
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    Synthesis of novel Ag(I)-N-heterocyclic carbene complexes soluble in both water and dichloromethane and their antimicrobial studies
    (Taylor & Francis Ltd, 2019) Boubakri, Lamia; Dridi, Khaireddine; Al-Ayed, Abdullah Sulaiman; Ozdemir, I.; Yasar, S.; Hamdi, Naceur
    The interaction of the benzimidazolium salt with Ag2O in dichloromethane to prepare novel Ag(I)-N-heterocyclic carbene complexes has been carried out at room temperature for 48 h in the absence of light. The obtained complexes were identified and characterized by H-1 and C-13 NMR, FT-IR and elemental analysis techniques. In addition, it has been found that some of the complexes are antimicrobially active and show higher activity than the free ligand. Probably metal chelation affects significantly the antimicrobial behavior of the ligands. The minimum inhibitory concentration of the complexes was determined. The results indicated that these complexes exhibit antimicrobial activity.