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    Synthesis and Investigation of Antimicrobial, Antioxidant, Enzymatic Inhibitory, and Antiproliferative Activities of Ruthenium (II) Complexes Bearing Benzimidazole-Based N-Heterocyclic Carbene (NHC) Ligands
    (Taylor & Francis Ltd, 2022) Hamdi, Naceur; Mansour, Lamjed; Al-Tamimi, Jameel; Al-Hazmy, Sadeq M.; Gurbuz, Nevin; Ozdemir, Ismail
    The benzimidazolium salts 2a-d were synthesized by quaternization of 1-(4-tet-buthylbenzyl) benzimidazole, with the corresponding benzysl bromide. The reactions were carried out in dimethylformamide at 70 degrees C for 48 h. Therefore, Ag2O and benzimidazolium salts 2a-d were reacted in dichloromethane at room temperature under dark and Ag(I)-NHC complex 3 was obtained in very good yields. The Ru(II)-NHC complexes (4a-d) were synthesized via transmetalation reaction from 3a-d. The structures of the obtained compounds were characterized by different spectroscopic techniques such as H-1 and C-13 NMR, elemental analysis, and melting point detection. The lowest MICs values were obtained with the two complexes 4b and 4d. Enzymatic inhibitory investigation against acetylcholinesterase (AChE) and tyrosinase (TyrE), showed that the two complexes 4b and 4d are the most potent inhibitors against (AchE) with an IC50 of 2.52 and 5.06 mu g mL(-1) respectively, and against (TyrE) with an IC50 of 19.88 and 24.95 mu g mL(-1) respectively. Screening of the selected N-Heterocyclic carbene (NHC) ligands (2a-2d) and their respective ruthenium (II) complexes (4a-4d) against colon carcinoma cells lines (HCT-116) and hepatocellular carcinoma cells lines (HepG-2). Furthermore, compounds 2c, 2d, 4b were showed weak cytotoxic action with IC50 ranging from 13.38 to 18.33 mu g in human colon carcinoma cancer cell lines and from 14.36 to 18.45 mu g in hepatocellular carcinoma cells lines.
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    Synthesis, structural characterization of silver(I)-NHC complexes and their antimicrobial, antioxidant and antitumor activities
    (Elsevier, 2020) Slimani, Ichraf; Mansour, Lamjed; Abutaha, Nael; Harrath, Abdel Halim; Al-Tamimi, Jameel; Gurbuz, Nevin; Ozdemir, I
    To prepare a novel series of silver (I) complexes, the interaction of benzimidazolium salts having their two nitrogen atoms substituted by bulky groups with Ag2O in DMF has been carried out. Their structures were characterized by elemental analyses, H-1 NMR, C-13 NMR and IR spectroscopy techniques. Further, the antibacterial properties of both the salts and their silver(I)-NHC complexes were tested against positive and negative bacteria using the agar dilution procedure. The results show that silver complexes are effective against Salmonella Typhimurium, Listeria monocytogenes, and Micrococcus luteus with moderate to high activity, and their minimum inhibitory concentrations ranging from 0.0024 to 1.25 mg/ml. Moreover, the antioxidant activity determination of these compounds were studied with the DPPH, and compared with (gallic acid GAand butylatedhydroxytoluene BHT ). They exhibited significant antioxidant activities. In addition, the of benzimidazoles salts 2a-j and silver-NHC complexes 3a-j were screened for their antitumor activity. The highest antitumor activity was observed for 3e and 3d Complexes and they exhibited IC50 values 6.85 mu g/mL against MCF-7 and 10.75 mu g/mL against T47D, respectively. (C) 2019 The Authors. Published by Elsevier B.V. on behalf of King Saud University.