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Öğe Assessment of the biocompatibility of mineral trioxide aggregate, bioaggregate, and biodentine in the subcutaneous tissue of rats(Wolters Kluwer Medknow Publications, 2015) Simsek, N.; Alan, H.; Ahmetoglu, F.; Taslidere, E.; Bulut, E. T.; Keles, A.Objective: The objective of this study was to evaluate the tissue inflammation caused by three endodontic repair materials. Materials and Methods: The materials included micro mega-mineral trioxide aggregate (MM-MTA), bioaggregate (BA), and biodentine (BD), which were implanted into the subcutaneous tissue of rats. The tissue samples for histological examination were prepared. The infiltration of lymphocytes and macrophages into the tissue was examined to assess the inflammatory response. Results: Lymphocyte infiltration: A significant increase was detected in the MM-MTA and BA groups on the 7th and 14th days as compared with the control (7th day P = 0.0001, 14th day P = 0.0176). There was no difference between the groups on the 45th day (P = 0.1730). Lymphocyte infiltration had decreased over time in all groups. Macrophage infiltration: There was a significant increase by the 7th day in the test groups as compared to the control group (P = 0.007). However, there was no difference between the experimental groups on the 14th (P = 0.2708) and 45th (P = 0.1291) days. Conclusion: While MM-MTA and BA showed a similar biocompatibility, BD was more biocompatible than MM-MTA and BA in the 1st week of the experiment. However, there was no difference between the materials at the end of the 45th day. MM-MTA, BA, and BD can be considered suitable endodontic repair materials.Öğe Effects of diode laser irradiation on dental pulps in rats(Comenius Univ, 2020) Guler, C.; Alan, H.; Demir, P.; Vardi, N.OBJECTIVES: To evaluate the effects of different power densities of diode laser on dental pulps in rats. BACKGROUND: In this study, we used the maxillary central incisors (n= 80) of the 40 adult male Wistar albino rats. METHODS: Rats were randomly divided into four groups according to power densities of diode laser (n= 10). Histopathological changes in pulp and height of odontoblast layer were examined. All data were compared statistically using Mann.Whitney U (Bonferroni) test, p< 0.05. RESULTS: G2 displayed slight histolopathologic alterations such as odontoblast cell disorganization and irregularities in cell extensions. Alterations were more prominent in the G3 than G2. Although the lowest odontoblast layer was measured in the G4, the difference in height of odontoblast layer among the groups was not found to be statistically significant. CONCLUSION: It was concluded that the use of diode laser caused changes at the cellular level in histological examination and may induce the formation of tertiary dentin by influencing the secretory activity of odontoblasts. As long as used in accordance with the recommended procedure, the diode laser can be safely used in dental hard tissues (Tab. 1, Fig. 4, Ref. 15). Text in PDF www.elis.sk.Öğe Effects of Melatonin on Tibia Bone Defects in Rats(Soc Chilena Anatomia, 2016) Koparal, M.; Irtegun, S.; Alan, H.; Deveci, E.; Gulsun, B.; Pektanc, G.The aim of this study was to evaluate the effects of melatonin healing in a tibial bone defect model in rats by means of histopathological and immunohistochemistry analysis. Twenty one male Wistar albino rats were used in this study. In each animal, bone defects (6 mm length) were created in the tibias. The animals were divided into three groups. In group 1 control group (rats which tibial defects). Group 2 melatonin (10 mg/kg) + 14 days in the tibial defect group) was administered intraperitoneally to rats. Group 3 melatonin (10 mg/kg) + 28 days in the tibial defect group) was administered intraperitoneally to rats. Histopathological analysis of samples was performed to evaluate the process of osteoblastic activity, matrix formation, trabecular bone formation and myeloid tissue in bone defects. Immunohistochemical and immunoblot analysis demonstrated non-collagenous proteins (osteopontin and osteonectin) differences in tibial bone defects. The expression of osteopontin on tibia was increased by 14 days melatonin treatment. The expression of osteonectin on tibia was dramatically increased by 14 days melatonin treatment.Öğe The histological study of osseous regeneration following implantation of various bone graft biomaterials(Wolters Kluwer Medknow Publications, 2016) Alan, H.; Farahani, E. M. Z.; Tunik, S.; Kavak, G.Background: While various biomaterials are used for bone regeneration, the relative comparative efficiency of them has not been thoroughly investigated. Purpose: This study evaluated histopathological events during osseous healing after implantation of following bone grafts: Demineralized freeze-dried cortical bone powder (DFDB), natural coral implants, calcium sulfate-based putty containing demineralized bone matrix (CaS-DBM), and pure-phase beta tricalcium phosphate ceramic granules (-TCP). Materials and Methods: Fifty-six Wistar Albino rats were used for this study. The postimplantation osseous healing was evaluated at 3(rd), 6(th) weeks after the operation. Results: DFDB did not induce bone formation in 3 weeks period, but it showed a highly osteoinductive effect at the end of 6(th) week period. The effects of coral implants on bone formation both at 3 and 6 weeks period were much higher than the DFDB. CaS-DBM showed higher bone formation than -TCP at 3(rd), 6(th) weeks. It was found that coral and CaS-DBM had a more beneficial impact on early bone healing compared to -TCP and DFDB. All these graft biomaterials are useable in human bone defects. The main difference in the ossous healing properties of these materials is observed early postimplantation with the delayed healing outcome being similar.Öğe Three-Dimensional Evaluation of the Effect of Low-Level Laser Therapy on Facial Swelling after Lower Third Molar Surgery: A Randomized, Placebo-Controlled Study(Wolters Kluwer Medknow Publications, 2018) Asutay, F.; Ozcan-Kucuk, A.; Alan, H.; Koparal, M.Purpose: This study aimed to evaluate the effect of a low-level laser therapy (LLLT) on pain, trismus, and swelling of patients whose impacted 3rd molar tooth was extracted compared to placebo or sham treatment and measure volumetrically the edema with a three-dimensional (3D) surface imaging device (3dMD face system). Materials and Methods: Forty-five patients over 17 years of age were included in the study. Patients were randomized to three groups; Group 1, the control group, received only routine management (ice application) (n = 15); Group 2, received single-dose LLLT immediately after surgery (n = 15); and Group 3, placebo group, received sham therapy immediately after surgery (n = 15). In this study, a gallium-aluminum-arsenide diode laser device was used. The laser was applied extraorally (0.3 W, 40 s, 4 J/cm(2)). The trismus, pain, and facial swelling were evaluated. A 3D surface imaging device (3dMD Photogrammetric System) was used to evaluate the volumetric changes of the swelling. The 3D morphology of the facial swelling was recorded using this imaging device immediately before surgery, the second day after surgery, and the 7th day after surgery. IBM SPSS statistics 22.0 program was used in the statistical assessment and P < 0.05 was considered statistically significant. Results: There was no statistically significant difference in the edema and trismus between the groups. The pain level in Group 2 was significantly lower than that in Group 3 at all-time points. Furthermore, the pain level in Group 2 was significantly lower than that in Group 1 on day 7. Conclusions: LLLT reduced the intensity of pain following third molar surgery by single dose. The results of this study revealed that LLLT reduced facial swelling, but no significant differences were found among the three groups. In addition, a 3D craniomaxillofacial imaging method provided insight into volume changes after 3rd molar surgery and the evaluation of facial swelling in an objective way.
