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    Evaluation of mean platelet volume, neutrophil/lymphocyte ratio and platelet / lymphocyte ratio relationship with disease severity and metabolic syndrome in patients with psoriasis vulgaris
    (2020) Hancer, Hilal Semra; Alatas, Emine Tugba
    Aim: Psoriasis is one of the diseases caused by chronic inflammation. It is associated with a number of comorbidities (metabolic syndrome, cardiovascular disease, obesity, non-alcholic fatty liver...). Recently, mean platelet volume (MPV), neutrophil lymphocyte ratio (NLR) and platelet lymphocyte ratio (PLR) were found to be related to systemic inflammation. At the end of this study, the risk of metabolic syndrome in psoriasis will be evaluated and the effect of MPV, NLR, PLR levels will be determined on predicting metabolic comorbidities in psoriasis patients.Material and Methods: This research was planned prospectively. The study consisted of 40 patients with psoriasis vulgaris and 40 healty control group which was similar in age and gender . Patients' informations were recorded and blood pressure, height, weight values were measured. Hemogram parameters, biochemistry values were determined.Results: The count of neutrophiles was higher in the psoriasis; but disease severity and neutrophil count were not related each other. According to our study, MPV values, high density lipoprotein (HDL), fasting blood glucose and body mass index (BMI) were meaningful findings in estimating the development of metabolic syndrome. Conclusion: The use of neutrophil activation markers in addition to neutrophil count in patients with psoriasis may be useful in determining disease severity and activation. In the follow-up of patients with psoriasis, fasting glucose, HDL, BMI value and MPV can help predicting possibility of metabolic syndrome and cardiovascular diseases that may develop in these patients.
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    Plasma and salivary irisin levels in lepramatous leprosy patients
    (2020) Alatas, Emine Tugba; Kalayci, Mehmet; Kara Polat, Asude; Dogan, Gursoy; Akin Belli, Asli
    Aim: We aimed to investigate the plasma and salivary irisin levels in leprosy patients, as well as to evaluate the role of the irisin in the leprosy pathogenesis. Leprosy is a granulomatous disease with the peripheral nerves, mucous membrane, and skin involvement primarily. Irisin, a novel protein, has been associated with several inflammatory diseases and demonstrated in the peripheral nerve cells, deep sebaceous glands, and saliva excessively. To our knowledge, there is no study investigating the irisin levels in patients with leprosy. Material and Methods: We conducted a case-control study on 20 patients with lepromatous leprosy and 20 healthy controls between January 2016 and January 2017. Of the participants, the demographic data and disease history including duration of the disease, any current treatments, and presence of any other family members with leprosy were recorded. The plasma and salivary irisin levels of the participants were measured by enzyme-linked immunosorbent assay (ELISA). Additionally, the serum levels of C-reactive protein (CRP), glucose, hemoglobin A1c (HbA1C), triglyceride, cholesterol, high-density lipoprotein (HDL) and low-density lipoprotein (LDL) were evaluated in both groups.Results: The plasma and salivary irisin levels were significantly lower in the patient group than those in the control group (P = 0.001 and P = 0.03, respectively). In patients with leprosy, the serum and salivary irisin levels had a positive correlation (r: 576, p: 0.008). In addition, there was a negative correlation between the plasma irisin and CRP levels (r: −468, p: 0.037).Conclusion: The irisin may act an immunomodulatory role in leprosy. The irisin production is probably suppressed by the increased inflammatory markers in leprosy or the bacillus to reach the temperature for its reproduction. Further studies are needed to clarify the role and prognostic value of the irisin in leprosy with a large number of patients examined before and after the treatments.