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    Cutaneous reactions after COVID-19 vaccination in Turkey: A multicenter study
    (Wiley, 2022) Cebeci Kahraman, Filiz; Savas Erdogan, Sevil; Aktas, Nurhan Doner; Albayrak, Hulya; Turkmen, Dursun; Borlu, Murat; Arica, Deniz Aksu
    Objectives In this study covering all of Turkey, we aimed to define cutaneous and systemic adverse reactions in our patient population after COVID-19 vaccination with the Sinovac/CoronaVac (inactivated SARS-CoV-2) and Pfizer/BioNTech (BNT162b2) vaccines. Methods This prospective, cross-sectional study included individuals presenting to the dermatology or emergency outpatient clinics of a total of 19 centers after having been vaccinated with the COVID-19 vaccines. Systemic, local injection site, and non-local cutaneous reactions after vaccination were identified, and their rates were determined. Results Of the 2290 individuals vaccinated between April 15 and July 15, 2021, 2097 (91.6%) received the CoronaVac vaccine and 183 (8%) BioNTech. Systemic reactions were observed at a rate of 31.0% after the first CoronaVac dose, 31.1% after the second CoronaVac dose, 46.4% after the first BioNTech dose, and 46.2% after the second BioNTech dose. Local injection site reactions were detected at a rate of 35.6% after the first CoronaVac dose, 35.7% after the second CoronaVac dose, 86.9% after the first BioNTech dose, and 94.1% after the second BioNTech dose. A total of 133 non-local cutaneous reactions were identified after the CoronaVac vaccine (2.9% after the first dose and 3.5% after the second dose), with the most common being urticaria/angioedema, pityriasis rosea, herpes zoster, and maculopapular rash. After BioNTech, 39 non-local cutaneous reactions were observed to have developed (24.8% after the first dose and 5% after the second dose), and the most common were herpes zoster, delayed large local reaction, pityriasis rosea, and urticaria/angioedema in order of frequency. Existing autoimmune diseases were triggered in 2.1% of the patients vaccinated with CoronaVac and 8.2% of those vaccinated with BioNTech. Conclusions There are no comprehensive data on cutaneous adverse reactions specific to the CoronaVac vaccine. We determined the frequency of adverse reactions from the dermatologist's point of view after CoronaVac and BioNTech vaccination and identified a wide spectrum of non-local cutaneous reactions. Our data show that CoronaVac is associated with less harmful reactions while BioNTech may result in more serious reactions, such as herpes zoster, anaphylaxis, and triggering of autoimmunity. However, most of these reactions were self-limiting or required little therapeutic intervention.
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    The role of serum Pro- and Anti-inflammatory cytokines as potential diagnostic markers for psoriasis
    (2020) Erdal, Berna; Albayrak, Hulya; Aydin Kurc, Mine; Varol, Gamze; Yanik, Mehmet Emin; Erfan, Gamze; Gulen, Dumrul
    Aim: Cytokines secreted by T helper cell subgroups are considered to play chief roles in the complex pathobiology of psoriasis. Herein, we aimed to reveal the effects of anti- and pro-inflammatory cytokines on the pathobiology of psoriasis disease and the correlation of these cytokines with severity of psoriasis. Materials and Methods: Thirty-seven individuals diagnosed with psoriasis and 37 healthy control subjects were enrolled for the study. The levels of Tumor necrosis factor alpha (TNFα), Soluble CD40 ligand (sCD40L), Interferon gamma (IFNγ) and Interleukin (IL) 1β, IL4, IL6, IL10, IL17F, IL17A, IL21, IL22, IL23, IL25, IL31, IL33 were determined by the Luminex method. Results: The IL6, IFNγ, TNFα, sCD40L, IL17F, IL17A, IL23, IL25, and IL31 levels were found to be markedly advanced in individuals with psoriasis in contrast to the control group (p=0.003, p=0.02, p0.001, p=0.02, p=0.03, p=0.003, p=0.04, p=0.04, and p0.05).Conclusion: IFNγ, IL6, TNFα, sCD40L, IL17F, IL17A, IL23, IL31, IL25 and inflammatory markers were markedly advanced in patients with psoriasis, strongly supporting the notion that these cytokines are involved in the pathobiology of psoriasis disease. In conclusion, findings of the present study suggest that understanding of the functions of these cytokines in the complex pathogenesis of psoriasis disease is of great interest for the future therapeutic intervention.