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    A Case of Isolated Central Nervous System Rosai-Dorfman Disease
    (Turkish Neuropsychiatry Assoc-Turk Noropsikiyatri Dernegi, 2024) Algul, Fatma Ebru; Erdem, Beguem Y. E. N., I; Yegen, Guelcin; Yolbas, Servet
    Rosai-Dorfman disease (RDD) is a benign histiocytosis with unknown etiology. It generally occurs in cervical lymph nodes. Isolated central nervous system (CNS) RDD is very rare in the literature. We reported a case of no systemic involvement Rosai-Dorfmann which is rarely seen and shows CNS involvement by mimicking meningioma. A 32 -year -old man presented with diplopia and a headache he has been experiencing for the past two years. His neurological examination showed left facial paresthesia, consistent with trigeminal nerve trace. Tendon reflexes were increased at the right side and the right plantar reflex was extensor. Brain magnetic resonance imaging demonstrated irregularly shaped, tumorlike lesions in the bilateral cerebellopontin area that were compressing pons. Rosai-Dorfman disease can be differentiated from IgG4 related disease (IgG4-RD) by its characteristic features such as plasma cell density and emperipolesis seen in its histopathology. Rosai-Dorfman disease can be confused with other diseases radiologically and histopathologically, especially the IgG4-RD, so be careful about differential diagnosis.
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    Ischemic stroke in young adults: Gender-based differences
    (2020) Algul, Fatma Ebru; Kaplan, Yuksel
    Abstract: Stroke is becoming a growingly more prevalent and significant public health problem among young adults around the world. Modifiable lifestyle-related risk factors are the most common cause of stroke in young adults. The aim of this study was to perform a gender-based evaluation of risk factors, stroke subtypes, severity of stroke, level of dependency at hospital discharge, and length of hospital stay among young patients with ischemic stroke in our region. The retrospective study included patients that were diagnosed with ischemic stroke based on patient history and clinical and radiographic findings at Inonu University Medical School Neurology Department between 2015 and 2018. The patients were divided based on gender and the two groups were compared with regard to age, gender, prior stroke, risk factors, neurologic deficits at hospital admission, etiology, radiographic localization, length of hospital stay, and the levels of disability and dependency at hospital discharge were reviewed for each patient. The study included a total of 105 patients diagnosed with ischemic stroke, comprising 65 (61.9%) men and 40 (38.1%) women. Mean age was 46.02±7.29 years in men and 41.18±8.2 years in women and a significant difference was observed between the two groups (p=0.002). The incidence of diabetes mellitus (DM), myocardial infarction (MI), and smoking was significantly higher in men compared to women (p=0.008, p=0.001, and p<0.001, respectively), whereas the incidence of mitral stenosis was significantly higher in women compared to men (p=0.0019). The results indicated that modifiable lifestyle-related risk factors are the most common cause of stroke in young adults and the significance of risk factors associated with stroke in young individuals differs between genders. Future studies with larger patient populations are needed to identify further risk factors and precautions for stroke in young adults.
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    A Neuromyelitis Optica Spectrum Disorder Case Presenting with the Syndrome of Inappropriate Antidiuretic Hormone Secretion
    (Gazi Univ, Fac Med, 2019) Algul, Fatma Ebru; Kamisli, Suat
    The syndrome of inappropriate antidiuretic hormone secretion (SIADH) is one of the most important causes of hyponatremia. SIADH has been associated many clinical states, syndromes and many other central nervous disorders. Neuromyelitis optica (NMO) and neuromyelitis optica spectrum disorders (NMOSD) are also a few of these. NMO is a demyelinating autoimmune disorder affected the brainstem and hypothalamus where express high levels of aquaporin-4 (AQP-4) protein. Although detecting antiaquaporin-4 antibody positive is important for the diagnosis, some NMO and NMOSD patients show seronegative AQP-4 antibody results. We report a seronegative NMO spectrum disorder case presenting with the SIADH.
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    The relationship between obesity and restless legs syndrome
    (2019) Algul, Fatma Ebru; Sertkaya, Ayse Cikim; Altınayar, Sibel
    Restless legs syndrome (RLS) has been shown to be more common in obese than in non-obese people in many studies. The aim of this study was to investigate passible relationship between obesity and seconder RLS prevalence and severity in the Turkish population. Method: A total of 70 volunteers were included in the study. Of these 44 were obese (BMI?30 kg/m2) and 26 were non obese(BMI <30 kg/m2. The International RLS Study Group (International Restless Legs Study Group, IRLSS) diagnosis criteria were used for the RLS diagnosis and International RLS criteria to determine the severity. 17 subjects had RLS and of these 13 were in the obese group and 4 in the non-obese group. No significant difference was found between obese and non-obese groups in terms of RLS prevalence (p:0.165) and RLS severity (p:0.918). Our study on a small sample from the Turkish population showed no significant relationship between obesity and RLS presence and severity. The reason may be the small numbers of obese and control group subjects in our study.
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    Serum adropin levels in patients with migraine
    (Bayrakol Medical Publisher, 2024) Algul, Fatma Ebru; Tosun, Hatice
    Aim: In this study, we aimed to investigate the relationship between migraine and serum adropin levels. Material and Methods: This is a randomized control study. The study was conducted for 6 months starting from January 2021. Fifty-four migraine patients were selected for the study as a case group and matched with 35 healthy participants for the control group. We compared serum adropin, high -density lipoprotein (HDL-C), low -density lipoprotein (LDL-C), total cholesterol (TC) and triglyceride (TG) concentration and body -mass index (BMI) between the case and control groups. In addition, the relationship between migraine disease duration, monthly pain frequency and pain duration, and serum adropin level in the patient group was analyzed. Results: There was no significant difference between the two groups regarding age, gender, triglyceride, LDL-C, HDL-C, BMI levels and serum adropin levels (p<0.05). Also, there was no significant difference in migraine disease duration, frequency of headache (within a month) and headache duration depending on serum adropin levels. A negative correlation was determined between adropin levels and age and BMI (p<0.05). Discussion: Serum adropin concentrations are not associated with migraine in our population. Besides, serum adropin levels decrease with increasing BMI and with age. With this knowledge, however, it is difficult to make a definitive conclusion. Further studies with larger populations are needed.
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    Serum salusin-? and -ß levels in patients with parkinson?s disease
    (Springer-Verlag Italia Srl, 2024) Algul, Fatma Ebru; Koc, Emine; Kaya, Hatice Tosun
    Background The etiology of Parkinson ' s disease (PD) is not well known and there is increasing evidence that oxidative stress also plays an important role in its pathogenesis. Salusins alpha (salusin-alpha) and beta (salusin-ss) affect the central nervous system, vasculature, and kidneys to increase the inflammatory response in endothelial cells, stimulate oxidative stress, and increase monocyte-endothelial adhesion. Neuroinflammation and oxidative stress play roles in the etiopathogenesis of PD. Purpose To investigate whether salusin-alpha and -ss are related to PD and whether they are correlated with the development of atherosclerosis, body mass index, disease duration, and the Parkinson ' s Hoehn and Yahr stage. Results The low-density lipoprotein cholesterol (LDL-C), total cholesterol, and salusin-ss levels were significantly lower and age was significantly higher in Parkinson patients compared to healthy controls (p < 0.005). We found a negative linear correlation between salusin-ss and the Hoehn and Yahr stage (p < 0.001, r = -0.515) in the patients. Conclusions There was a relationship between salusin-ss and PD and a correlation between the salusin-ss levels and Parkinson's stage. A possible underlying disease mechanism is an increase in oxidative stress and decrease in neuroprotective effects due to low salusin-ss levels. Therefore, the effects of salusin-ss in treating Parkinson disease should be evaluated. Further studies are needed to understand the effects of salusin-ss treatment on preventing or slowing the course of PD.