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Öğe Cerebral Venous Sinus Thrombosis After Spinal Anesthesia: Case Report(Elsevier Science Bv, 2011) Yucel, Neslihan; Akgun, Feride Sinem; Tekin, Yusuf Kenan; Altinayar, Sibel; Alkan, AlpayCerebral venous sinus thrombosis is a rare clinical disorder which frequently shows up as prolonged headache unresponsive to standard therapies following spinal anesthesia. In this study, a 24 years old male presenting to our emergency department (ED) after many visits to other ED with headache which started following spinal anesthesia underwent fifteen days ago and being diagnosed with cerebral sinus venous thrombosis upon the evaluations is reported.Öğe Decision-making and impulse-control disorders in Parkinson's disease: Influence of dopaminergic treatment(Wolters Kluwer Medknow Publications, 2020) Yildirim, Elif; Altinayar, Sibel; Cakmur, RaifObjective: Dopaminergic treatment is proved to ameliorate motor deficits in Parkinson's disease (PD); however, it could have negative effects on behavior and cognition, including impulse controlling and decision-making. We aimed (1) to investigate the decision-making and impulse-control disorders (ICDs) of PD patients and their correlations with sociodemographical and clinical variables, dopaminergic treatment in particular, and (2) to determine the relation of decision-making with ICDs. Methods: The sample of 39 patients with PD and 37 healthy controls underwent cognitive tests and the task which analyzed decision-making (Iowa Gambling Task [IGT]). Besides assessing motor and nonmotor symptoms of patients with PD, ICDs were also scanned using the Questionnaire for Impulsive-Compulsive Disorders in Parkinson's Disease. Results: Although patients with PD performed similarly to healthy controls on IGT, decision-making profile in PD related to clinical variables: dopaminergic treatment and duration of illness. In addition to this younger age of onset, higher dose of dopamine agonists, longer duration of illness, and impaired decision-making were together accounted for a substantial amount of variance in impulsive behaviors. Conclusions: Dopaminergic medication likely contributes to the impairment in decision-making, which may be the underlying mechanism of ICDs. Further studies will be necessary to understand the potential implications of this finding.Öğe Episodic Paroxysmal Hemicrania with an Atypical Clinical Presentation: A Case Report and Review of the Literature(Turkish Neurological Soc, 2015) Kaplan, Yuksel; Kamisli, Ozden; Altinayar, SibelParoxysmal hemicrania (PH) is characterized by frequent, short-lasting, severe, unilateral headaches that occur in association with cranial autonomic features. The hallmarks of this syndrome are relatively short attacks and a complete therapeutic response to indomethacin. Although PH has been classified as strictly unilateral headache in association with cranial autonomic features, a few cases have been reported that suggest bilateral PH. We report a case of PH with bilateral distribution and bilateral autonomic features. PH may actually represent a clinical spectrum including different phenotypes.Öğe Is there a relationship between Toxoplasma gondii infection and idiopathic Parkinson's disease?(Informa Healthcare, 2010) Celik, Tuncay; Kamisli, Ozden; Babur, Cahit; Cevik, Muhammer Ozgur; Oztuna, Derya; Altinayar, SibelIdiopathic Parkinson's disease defines a group of Parkinson's disease (PD) of which the aetiology is unknown but an underlying brain disease is suspected. We selected patients of this subgroup of PD and investigated the seropositivity rate for anti-Toxoplasma IgG antibody by Sabin-Feldman dye test (SFDT). By measuring seropositivity in PD patients, we searched for a probable relationship between Toxoplasma gondii infection and idiopathic PD incidence. Fifty patients diagnosed with idiopathic PD and 50 healthy volunteers were included in the study. Blood samples were taken from all 100 participants and anti-T. gondii antibody titres were investigated using SFDT. Anti-T. gondii antibodies were detected at a titre of >= 1/16 in 25 of the 50 patients (50%) and in 20 of the control group (40%). No higher antibody titre was found in the control group. In conclusion, despite the emerging literature on a possible relationship between T. gondii infection and neurological disease, and the high anti-T. gondii seropositivity found in our PD patients, we did not detect any statistically significant association between T. gondii and idiopathic PD.Öğe Jaffe Campanacci Syndrome and Non-Convulsive Status Epilepticus: A Case Report(Galenos Yayincilik, 2010) Kamisli, Ozden; Kamisli, Suat; Altinayar, Sibel; Kablan, Yueksel; Ozcan, CemalJaffe-Campanacci syndrome consists of non-ossifying fibromas of the bones and cafe au lait spots. Mental retardation is also observed in some patients. Non-convulsive status epilepticus may be associated with various diseases. However, to our knowledge, no association between these two conditions has been reported in the literature. We report a patient with Jaffe-Campanacci syndrome who developed non-convulsive status epilepticus. (Archives of Neuropsychiatry 2010; 47: 78-80)Öğe Lower extremity isokinetic muscle strength in patients with Parkinson's disease(Elsevier Sci Ltd, 2010) Durmus, Bekir; Baysal, Ozlem; Altinayar, Sibel; Altay, Zuhal; Ersoy, Yuksel; Ozcan, CemalWe evaluated lower extremity isokinetic muscle strength to determine affected muscle groups and their dependence on movement velocity, and to establish the relationship between muscle strength and clinical severity, as well as muscle strength and falls, in Parkinson's disease (PD) Twenty-five patients diagnosed with PD and 24 healthy volunteers were enrolled in this study Lower extremity muscle strength was measured using an isokinetic dynamometer Each participant's clinical status was examined in accordance with the Unified Parkinson's Disease Rating Scale, fall history was also recorded We observed a significant decrease in isokinetic muscle strength in the patient group, especially in both hip and knee flexors and extensors Decreased muscle strength was independent of velocity, and col related with clinical severity and falls Movement velocity-independent lower extremity isokinetic muscle weakness has been observed in patients with PD, especially in the knee and hip joints The evaluation of isokinetic muscle strength may be a useful tool for the assessment of clinical severity and falls in PD (C) 2010 Elsevier Ltd All rights reservedÖğe P50 Sensory Gating in Children and Adolescents with Developmental Stuttering(Kure Iletisim Grubu A S, 2009) Ozcan, Ozlem; Altinayar, Sibel; Ozcan, Cemal; Unal, Suheyla; Karlidag, RifatObjective: Stuttering is a speech disorder, where speech fluency is disturbed by the involuntary repetition and prolongation of words and syllables. Its cause is not fully known. Sensory gating is an essential part of information processing and developing an appropriate behavioral response in the brain. Psychological, social, and learning-related factors together with sensorymotor variables play an important role in ensuring fluent speech. Sensory gating protects the brain from overload by filtering the redundant or potentially irrelevant information from the continuous and intensive stream of information. A lack of sensory gating for auditory stimuli may lead to disturbed auditory signal processing and auditory feedback and result in loss of speech fluency. Our aim in this study was to evaluate the state of sensory gating in children and adolescents with developmental stuttering using P50 suppression to test our hypothesis that sensory gating may be disturbed in stuttering. Method: A total of 20 stuttering children and adolescents in 7-18 age group and 20 age-and sex-matched healthy controls with no speech problems were included in the study. All children underwent psychiatric evaluation by a pediatric psychiatrist. Patients with psychiatric, neurological or chronic disease, those who had a history of using medication that could affect the central nervous system and children with a family history of schizophrenia were excluded from the study. P50 suppression was then recorded with an electroencephalogram (EEG). Statistical analysis was performed using the SPSS package software program. The Mann-Whitney U test was used to compare the P50 values of the two groups and p value <0.05 was considered significant for all analyses. Results: The mean age for the children and adolescents included in the study was 11.8 +/- 2.7 years and the age stuttering started was 4.6 +/- 1.1 years. There were 16 males (80%) and 4 females (20%) in both groups. There was no statistically significant difference between the P50 amplitude, latency and P50 suppression ratios of the two groups. Conclusion: The results of this study have shown no association between P50 and stuttering in children and adolescents. However, this first study evaluating sensory gating in children and adolescents should be repeated with prepulse inhibition, another test used to evaluate sensory gating, on larger samples and in different age groups.Öğe RELATIONSHIPS BETWEEN PARKINSON'S DISEASE DEMENTIA AND 25-HYDROXY VITAMIN D AND BRAIN-DERIVED NEUROTROPHIC FACTOR LEVELS(Gunes Kitabevi Ltd Sti, 2021) Ekmekyapar, Tuba; Turkoz, Yusuf; Erdemli, Zeynep; Demirtas, Yasemin; Altinayar, SibelIntroduction: Parkinson's disease dementia is an important condition that worsens the quality of life in approximately 30% of parkinson disease patients. Vitamin D deficiency and brain-derived neurotrophic factor have been implicated in the pathogenesis of alzheimer type dementia, parkinson's disease, and many neurodegenerative diseases. The aim of this study was to investigate the relationship between cognitive impairment and 25-hydroxy vitamin D and brain-derived neurotrophic factor levels in parkinson's disease dementia patients. Materials and Method: 25-hydroxy vitamin D and brain-derived neurotrophic factor serum levels were evaluated in patients with parkinson's disease dementia (n = 63) and healthy controls (n = 33). Brain-derived neurotrophic factor and vitamin D levels were examined using one sample t-tests, and multiple comparisons among independent groups were done using ANOVA post hoc Tukey's test analysis. Wechsler Memory Scale and Mini-Mental State Examination were used to evaluate the cognitive functions of the groups. The disease levels of the patients were determined using the Hoehn and Yahr scale and the Unified Parkinson's Disease Rating Scale. Results: There was a significant negative correlation between the worsening of dementia and vitamin D levels (p = 0.009). However, there were significant negative correlations between the unified parkinson's disease rating scale daily living activity and Hoehn and Yahr scales and vitamin D levels. No significant relationship was found between brain-derived neurotrophic factor and parkinson's disease dementia (p = 0.983). Conclusions: Vitamin D deficiency plays a role in cognitive loss in parkinson's disease dementia. Vitamin D replacement can be used in dementia support treatment.
