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Öğe Anterior Prostatic Cyst Causing Acute Urinary Retansion in a Young Patient(Derman Medical Publ, 2016) Celik, Huseyin; Camtosun, Ahmet; Topcu, Ibrahim; Altintas, Ramazan; Tasdemir, CemalProstatic cysts are rare entities. Mostly, they originate from the posterior area of the prostate and asymptomatic. Anterior location of the prostatic cyst is rarer than posterior. The prostatic cyst in a 41 year-old man presenting with acute or nary retansion. Transurethral resection FUR) of the cyst was performed, which revealed a benign cyst lined with columnar epithelium and proliferative urothelial lining on histopathological evaluation. Prostatic cysts particularly in young men with obstructive lower urinary tract symptoms are rarely seen. Management of the prostatic cyst with TUR seems to be a minimally invasive approach with successful outcomes.Öğe ASSESSMENT OF FEMALE PATIENTS PRESENTING WITH URINARY INCONTINENCE(Mary Ann Liebert, Inc, 2012) Altintas, Ramazan; Oguz, Fatih; Beytur, Ali; Kati, Bulent; Gunes, Ali[Abstract Not Available]Öğe Assessment of urinary incontinence in the women in Eastern Turkey(Springer London Ltd, 2013) Altintas, Ramazan; Beytur, Ali; Oguz, Fatih; Tasdemir, Cemal; Kati, Bulent; Cimen, Serhan; Colak, CemilThe aims of the present study were to determine the types of UI among women visiting the urology department, to identify the potential risk factors associated with each type of UI, and to identify healthcare-seeking behaviors of affected women in our region. The data of 617 community-dwelling women, who were at least 18 years of age or older and who presented with a complaint of UI ongoing over a year, and those without UI, who were admitted for any other reason, from June 2010 to April 2012, were evaluated. Mean age was 51.29 years (range 18-110 years); median parity was 3.54 (range 0-11) and 88.2 % of the women were married. Mean BMI was 28.01 kg/m(2). Very few women (18.5 %) accepted UI as a disease and searched for medical help by themselves; however, the remaining women (81.5 %) were brought or directed for evaluation by someone else. Stress UI was reported by 43 women (10.5 %), urge UI and mixed UI were noted by 153 (37.5 %) and 212 (52 %) women respectively. The most frequent type of UI was mixed UI in our region. Age, BMI, multiparity, and hypertension were identified to have a different importance for each type of UI, but diabetes mellitus, birth trauma, gynecological surgery, lumbar disc hernia (LDH), and multiple sclerosis (MS) were the other important related factors. However, a small number of patients accepted UI as a disease and searched for therapy. This reveals that the public should be informed in detail about female UI in developing countries.Öğe A Case of Cystitis Mimicking Bladder Tumor(Galenos Yayincilik, 2016) Camtosun, Ahmet; Celik, Huseyin; Altintas, Ramazan; Akpolat, NusretChronic cystitis is a usual inflammatory disease of the bladder in children. Patients typically show irritative voiding symptoms. In addition, bladder mass accumulation with the possibility of malignancy can rarely be observed. We present a 12-year-old male patient in whom radiological investigations showed a focal papillary lesion. In this paper, we aimed to discuss the management of chronic cystitis.Öğe A Case of Hydatid Cyst Mimicking Kidney Tumor(Aves, 2019) Camtosun, Ahmet; Celik, Huseyin; Yildiz, Ahmet; Altintas, Ramazan; Tasdemir, CemalA 45-year-old male patient presented with left flank pain that started a month ago. There was no history of fever or pyuria. Vital signs were normal. The rest of the systemic examination was unremarkable. There were no pathological findings on urinalysis or urine cytology. Ultrasonography revealed an 8x6.2x6 cm heterogeneous exophytic trending lesion at the lower pole of the left kidney. The lesion's walls were seen to be calcified in places, and the margin between the kidney and lesion was indistinct. It could not be differentiated by ultrasonography if the lesion is a complicated cyst or a mass. Magnetic resonance imaging scan of the upper abdomen also revealed a 9x7.5x7 cm cortical-parapelvic localized lesion at the lower pole of the left kidney, extending exophytically to the inferior. Given the possibility that the lesion is malignant, nephrectomy was planned. A laparoscopic approach was performed. Histopathological diagnosis was hydatid cyst. Enzyme-linked immunosorbent assay test for hydatid disease was negative. Albendazole 10 mg/kg twice a day was administered postoperatively for 3 weeks.Öğe Comparison of Percutaneous Nephrolithotomy Results in Pediatric Kidney Stone Disease in Patients Under the Age of 10 Years and in Patients Over the Age of 10 Years(Aves, 2016) Celik, Huseyin; Ediz, Caner; Camtosun, Ahmet; Altintas, Ramazan; Tasdemir, CemalObjective: Percutaneous nephrolithotomy (PNL) is a minimally invasive procedure that is safely performed for kidney stone surgery all over the world. In our clinic, PNL surgery was first performed in March 1998. In parallel with our increasing experience, PNL has been performed in pediatric cases. In our study, PNL operations performed in pediatric patients under the age of 10 years and in those over the age of 10 years were retrospectively investigated. Methods: Patients were between 0 and 16 years of age. They were divided into 2 groups according to age: 0-10 and 11-16 years. The PNL procedure was performed under general anesthesia with C-arm fluoroscopy in the prone position. Results: Between March 1998 and December 2014, a total of 208 pediatric urinary stone patients were operated on. The PNL procedure was performed in 210 renal units, 1 of which was performed bilaterally. In the <= 10-year-old patient group, 98 procedures (87.5%) were stone free, while clinically insignificant residual fragments (CIRFU) were found in 13 procedures (12.5%). In the > 10-year-old patient group, 88 procedures were stone free (89.79%), while clinically insignificant residual fragments were found in 9 procedures (10.2%). In the <= 10-year-old patient group, tubeless PNL was performed in 1 patient. In both groups combined, bleeding requiring transfusion occurred in just 1 case. A tract leak requiring a double J stent was detected in 1 patient in the <= 10-year-old patient group and in 2 patients in the other group. There was no other organ injury. Conclusion: PNL is a minimally invasive method and has become advantageous over open surgery because it offers higher security, particularly in experienced clinics, and procedures on pediatric patients can therefore be successfully performed.Öğe Comparison of the results of pediatric percutaneous nephrolithotomy with different sized instruments(Springer, 2017) Celik, Huseyin; Camtosun, Ahmet; Dede, Onur; Dagguli, Mansur; Altintas, Ramazan; Tasdemir, CemalWe aim to compare the outcomes, including the morbidity and success rates in children undergoing percutaneous nephrolithotomy (PCNL) using different sized devices. According to the size of instruments used during surgery, three different groups (ultra-mini-PCNL, mini-PCNL and adult size PCNL) were composed and the outcomes were compared between the groups. PCNL was applied to 225 renal units of 220 children, including 5 patients with bilateral kidney stones. Percutaneous nephrolithotomy was performed using adult instruments (24 F) in 82 renal units, using pediatric instruments (18 F) in 89 and using minimal-size instruments (9.5 F) in 50. One-hundred and twenty-four girls and 96 boys with a mean age of 8.33 (< 17) years were assessed. Stone-free rates were 78 % in group 1 (n = 39) using 9.5 F nephroscope, 75.8 % in group 2 (n = 69) using 18 F nephroscope and 71.4 % in group 3 (n = 60) using 24 F nephroscope. Time to access the collecting system, operative time, duration of nephrostomy and average postoperative hospital stay did not differ between the groups. However, mean hematocrit drop and stone burden were significantly lesser in ultra-mini-PCNL group. There was no significant difference in the complication rates between the groups, according to the modified Clavien classification system. As the important complication of PCNL, bleeding seems to be associated with diameter of dilatation, calibre of nephroscopes and stone burden. To reduce the certain complications, pediatric type of instruments is suitable but the use of adult instruments and techniques may achieve equal results.Öğe Does preoperative neutrophil-to-lymphocyte ratio have a value in predicting recurrence in bladder tumour after intravesical BCG treatment?(Scientific Publishers India, 2017) Camtosun, Ahmet; Celik, Huseyin; Altintas, Ramazan; Topcu, Ibrahim; Tasdemir, CemalThe purpose of this study was to evaluate the prognostic value of the ratio of preoperative neutrophil to lymphocyte after intravesical BCG treatment in non-muscle invasive bladder cancer (NMIBC). The data of 89 patients, operated for urothelial carcinoma and treated with BCG after the diagnosis of NMIBC between 2007 and 2014, were reviewed retrospectively. Preoperative complete blood counts and first cystoscopic examination findings of the patients were examined. Median follow-up was 28.7 months. Tumour recurrence was detected in 33 patients (Group 2) of 89 patients. There was no tumour recurrence in 56 patients (Group 1). Neutrophil/lymphocyte ratio, MPV and CIS incidence were significantly increased in Group 2. This study showed that, preoperative high neutrophil/lymphocyte ratio, MPV and CIS occurrence can be used as independent criteria to predict tumour recurrence after intravesical BCG treatment in NMIBC.Öğe EFFECT OF SELECTION OF ACCESS CALYX ON SUCCESS OF PERCUTANEOUS NEPHROLITHOTOMY(Mary Ann Liebert, Inc, 2012) Altintas, Ramazan; Beytur, Ali; Oguz, Fatih; Cimen, Serhan[Abstract Not Available]Öğe Giant Hydronephrosis and Nonfunction Kidney Dependent to Ureter Tumor: A Case Report(Galenos Yayincilik, 2015) Cimen, Serhan; Altintas, Ramazan; Gunes, AliTransitional epithelial cancers in upper urinary tract are quite rare. It is less often being synchronous with the bladder cancer and this situation needs closer follow-up of the patient. In this case report, we evaluated a 56 years-old male having a giant hydronephrosis and nonfunctional kidney, urethra tumor in the light of current literature. The patient presented with right flank pain, palpable abdominal mass and intermittent hematuria in last one years.Öğe How do vegetable oils (hazelnut and canola) affect the reproductive system in male rats?(Pagepress Publ, 2018) Kati, Bulent; Oguz, Fatih; Yilmaz, Ismet; Akdemir, Ender; Altintas, Ramazan; Akpolat, Nusret; Taskapan, Mehmet CagatayObjective: Vegetable oils have an important place in our daily diet. This study starts from this point to investigate the effects of canola oil and hazelnut oil in the male reproductive system in rats. Material and methods: 30 male rats were used in this 16-week study. The animals were divided into three groups: the animals in group I served as the control group, while the animals in group II and group III were fed with hazelnut and canola oil, respectively. The testes of all rats were excised for histopathologic evaluation and immunohistochemical (IHC) evaluation with a standard method. Blood samples were obtained for determination of serum hormone levels. Results: No significant differences were noted with respect to behavior or weight among the three groups. Rats in the canola oil group (group III) had higher luteinizing hormone (LH) and higher testosterone levels than rats in the control group. Rats who received hazelnut oil (group II) exhibited similar findings, with these levels being higher than they were in the control group. No statistical differences were shown for histopathology or IHC testosterone antibody levels across all treatment groups. Conclussion: Canola oil was shown to have a greater effect on serum LH and testosterone compared to the control group and the group fed with hazelnut oil. Further investigation is required into how these oils affect serum hormone and sperm activity.Öğe How safe is the monoplanar access technique for percutaneous nephrolithotomy?(Springer, 2013) Oguz, Fatih; Altintas, Ramazan[Abstract Not Available]Öğe THE IMPORTANCE OF ENSTRUMENT TYPE IN PEDIATRIC PERCUTANEOUS NEPHROLITHOTOMY(Mary Ann Liebert, Inc, 2012) Altintas, Ramazan; Beytur, Ali; Oguz, Fatih; Cimen, Serhan[Abstract Not Available]Öğe The importance of instrument type in paediatric percutaneous nephrolithotomy(Springer, 2014) Altintas, Ramazan; Oguz, Fatih; Tasdemir, Cemal; Beytur, Ali; Cimen, Serhan; Gunes, Ali; Colak, CemilWe reported our experience with percutaneous nephrolithotomy in children and compared the outcomes, including the morbidity and success rates, regarding the instruments of different sizes. One hundred and seventy-three paediatric patients, who underwent percutaneous nephrolithotomy in our clinic between 1999 and 2013, were assessed. According to the size of instruments used during surgery, three different groups were formed and the pre- and postopeartive outcomes were compared between the groups. 76 girls and 97 boys with a mean age of 9.24 (a parts per thousand currency sign17) years were assessed. Stone-free rates were 75.6 % in group 1 (n = 82) using 17 F nephroscope, 79.4 % in group 2 (n = 73) using 24 F nephroscope and 72.2 % in group 3 (n = 18) using 26 F nephroscope. Postoperative fever was seen in four, five and one patient in group 1, 2 and 3, respectively. Urinary infection was seen in one patient in group 1 and four patients in group 2. Mean haematocrit drop and stone burden were significantly lesser in group 1. No significant difference was seen in the duration of nephrostomy and hospitalization between the groups. The success rates obtained in the groups using different instrument types (paediatric or adult) were similar. However, age, weight, height, stone burden and bleeding were significantly lesser in group 1 that used paediatric type of instrument. As the most frequent complication of PNL, bleeding seems to be associated with stone burden, the diameter of dilatation and the calibre of instrument. To decrease the particular complications, paediatric type of instruments are convenient and do not affect the success.Öğe Minimally invasive approaches and their efficacy in pediatric urolithiasis(Aves, 2013) Altintas, Ramazan; Beytur, Ali; Oguz, Fatih; Cimen, Serhan; Akdemir, Ender; Gunes, AliObjective: We compared the frequency of usage and success of minimally invasive approaches in the management of pediatric urolithiasis in our clinic. Material and methods: Data from pediatric patients (<= 16 years of age) who had undergone percutaneous nephrolithotomy (PNL), ureterorenoscopy (URS), and extracorporeal shock wave lithotripsy (ESWL) between January 2001 and December 2011 were retrospectively investigated. Results: In this study, 415 pediatric patients, who were treated for 291 renal, and 124 ureteral stones, were evaluated. The patients were treated with PNL (n=148; 82 boys, 66 girls), URS (n=99; 58 boys, and 41 girls) or ESWL (n=168; 91 boys, and 77 girls). The mean patient ages were 7.3 (1-16), 9.1 (1-16), and 8.8 (1-16) years in the PNL, URS, and ESWL groups, respectively. The stone-free rates after treatment with PNL, URS, and ESWL were 77, 83.8 and 88.7%, respectively. Conclusion: It is important that selected therapies are properly planned, and the use of minimally invasive approaches is important in pediatric patients due to potentially high recurrence rates. Currently, ESWL, PNL and URS are performed with high success rates for the treatment of stones, and open surgery is rarely used due to the success obtained with minimally invasive approaches.Öğe OUR PERCUTANEOUS NEPHROLITHOTOMY EXPERIENCES OF PEDIATRICS CASES (UNDER THREE YEARS OLD)(Mary Ann Liebert, Inc, 2012) Beytur, Ali; Oguz, Fatih; Altintas, Ramazan; Gunes, Ali[Abstract Not Available]Öğe Percutaneous nephrolithotomy in children with pediatric and adult-sized instruments(Elsevier Sci Ltd, 2016) Celik, Huseyin; Camtosun, Ahmet; Altintas, Ramazan; Tasdemir, CemalObjective Pediatric stone disease is a significant health issue which has increased in incidence because of lifestyle changes, dietary habits, and obesity. The incidence of urolithiasis among pediatric age groups varies according to region and is high in Turkey. The management of stone disease in children has improved dramatically over the last two decades. The high success rate of percutaneous nephrolithotomy (PNL) have led modern researchers to suggest that it be used as a first-line treatment of kidney stones greater than 2 cm in size. This study compared the outcomes, including morbidity and success rates, of different groups of pediatric patients who underwent PNL via pediatric-and adult-sized instruments. Methods Percutaneous nephrolithotomy was performed in 194 children in a clinical setting between the years 2000 and 2015. Patients were categorized into 2 groups (group 1: pediatric-sized devices used, n = 90 [46.4%]; group 2: adult-sized devices used, n = 104 [53.6%]). The children in group 2 were further divided into subgroups: a 24 F nephroscope was used for group 2a (n=84 [43.3%]) and a 26 F nephroscope was used for group 2b (n = 20 [10.3%]) (Figure). Results For this study, a total of 194 pediatric patients (99 boys and 95 girls ranging from 8 months to 17 years of age, with a mean age of 9.43 years) underwent PNL for the removal of kidney stones in a clinical setting. Between the examined groups, there were no significant differences in patient height or weight, stone site or localization, pre-and post-operative creatinine levels, duration of nephrostomy, or hospitalization time. There was also no significant variation in minor complications such as fever or urinary infection. However, the stone burden was notably smaller in the group wherein pediatric-sized nephroscopes were used. Additionally, the incidence of hemorrhage was markedly lower in groups where a 17 F nephroscope was used than in groups where treatment was administered via 24 and 26 F nephroscopes. Conclusions Stone disease is considered to be relatively rare in childhood, but recent studies have indicated that it presents a considerable health problem. According to some researchers, a decrease in instrument size has not meaningfully reduced complication rates. In contrast, some studies have reported that the use of smaller sized nephroscopes may reduce rates of morbidity and mortality. In this study, success rates of PNL were similar across all groups, regardless of nephroscope size. However, the use of a 17 F nephroscope significantly decreased the rate of hematocrit level reduction (p < 0.001). While instrument size does not affect the success of PNL, smaller instruments can be used to reduce various complications such as bleeding.Öğe The Protective Effect of Apocynin on Testicular Ischemia-Reperfusion Injury(Lippincott Williams & Wilkins, 2015) Ozbek, Ozkan; Altintas, Ramazan; Polat, Alaaddin; Vardi, Nigar; Parlakpinar, Hakan; Sagir, Mustafa; Duran, Zeynep RumeysaPurpose: We investigated the protective effect of the NADPH oxidase inhibitor apocynin on testicular damage induced by ischemia-reperfusion injury in rats. Materials and Methods: A total of 32 rats were randomly divided into 4 groups. Controls underwent left scrotal exploration only. The 3 groups with ischemia-reperfusion underwent 4-hour torsion followed by 1-hour detorsion. The ischemia-reperfusion only group underwent left testicular torsion and detorsion. The ischemia-reperfusion plus saline group underwent left testicular torsion, received 10 ml/kg saline intraperitoneally at minute 210 of ischemia and then underwent detorsion. The ischemia-reperfusion plus apocynin group underwent left testicular torsion, received 20 mg/kg apocynin intraperitoneally at minute 210 of ischemia and then underwent detorsion. We determined histopathological findings and performed specific biochemical analyses. Results: In the ischemia-reperfusion only and the ischemia-reperfusion plus saline groups malondialdehyde, total oxidative capacity and the oxidative stress index were significantly higher. Superoxide dismutase, catalase, glutathione peroxidase and glutathione were significantly lower. Apocynin significantly decreased malondialdehyde, total oxidative capacity and the oxidative stress index, and significantly increased superoxide dismutase and catalase. There was a significantly increase in the number of giant, degenerated and desquamated cells in the ischemia-reperfusion group. Apocynin significantly improved these histological alterations. Conclusions: These histopathological and biochemical findings show the beneficial effects of apocynin on testicular ischemia-reperfusion injury.Öğe Protective Effect of Dexpanthenol on Ischemia-Reperfusion-Induced Renal Injury in Rats(Karger, 2012) Altintas, Ramazan; Parlakpinar, Hakan; Beytur, Ali; Vardi, Nigar; Polat, Alaadin; Sagir, Mustafa; Odabas, Gul PelinBackground/Aims: This experimental study was designed to investigate protective and therapeutic effects of Dexpanthenol (Dxp), an alcoholic analogue of pantothenic acid, on kidney damage induced by ischemia-reperfusion (I/R) in rats. Methods: Forty rats were randomly divided into a control group and 4 I/R groups (1 h ischemia followed by 23 h reperfusion). Three I/R groups were treated by Dxp (500 mg/kg, i.p.) at 3 different time points (before ischemia, during ischemia and late reperfusion). The histopathological findings including apoptotic changes, and also tissue malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPX), blood urea nitrogen (BUN), serum creatinine (Cr) and albumin (Alb) levels were determined. Results: Kidney tissue MDA levels were found to be significantly higher in the I/R group, whereas the values of GPX were lower when compared to the control group. The levels of SOD and CAT did not reach to statistical meaning level in I/R group. Dxp given during ischemia reduced the elevated MDA levels to the nearly control levels and this ameliorating effect was found as parallel to the result of GPX. Serum levels of BUN and Cr were significantly higher in I/R group. Dxp given during ischemia significantly reduced the elevated BUN and Cr levels when compared to I/R group. Renal I/R injury also induced extensive tubular necrosis, glomerular damage and apoptosis in the histological evaluation. Dxp ameliorated these histological damages in different amounts in all treatment groups. Conclusion: In this study the protective effects of Dxp against renal I/R injury has been evaluated for the first time. Copyright (c) 2012 S. Karger AG, BaselÖğe The Protective Effects of Apocynin on Kidney Damage Caused by Renal Ischemia/Reperfusion(Mary Ann Liebert, Inc, 2013) Altintas, Ramazan; Polat, Alaadin; Vardi, Nigar; Oguz, Fatih; Beytur, Ali; Sagir, Mustafa; Yildiz, AzibePurpose: This experimental study was designed to explore the protective effect of apocynin, the NADPH-oxidase inhibitor, on kidney damage induced by ischemia/reperfusion (I/R) in a rat model. Methods: Thirty-two rats were randomly divided into a control group and three I/R groups (1-hour ischemia followed by 23-hour reperfusion). Three I/R groups were treated by apocynin (20 mg/kg, i.p.) at two different time points (before ischemia and during ischemia). The histopathological findings, including apoptotic changes, and also tissue malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), glutathion peroxidase (GPX), reduced glutathione (GSH), myeloperoxidase (MPO), blood urea nitrogen (BUN), and serum creatinine (Cr) levels, were determined. Results: Kidney tissue MDA and MPO, and serum BUN and Cr levels were found to be significantly higher in the I/R group, but there was no statistically significant difference in the levels of SOD, CAT, GPX, and GSH between the I/R and the control groups. Although apocynin significantly reduced MDA and MPO in group 3 and increased GPX in both treatment groups when compared to the I/R group, the elevated BUN and Cr levels were significantly reduced in treatment groups. Renal I/R injury also induced extensive tubular necrosis, glomerular damage, and apoptosis in the histological evaluation. Apocynin, especially when used during ischemia, ameliorated these histological damages in different amounts in treatment groups. Conclusion: The beneficial effects of apocynin on renal I/R injury were evaluated for the first time.
