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    An evaluation of the neutrophil-to-lymphocyte ratio as a prognostic and predictive marker in thromboangiitis obliterans
    (2018) Altun, Gokalp; Hemsinli, Dogus
    Aim: The aim of this study was to investigate whether the neutrophil/lymphocyte ratio is an independent predictor of poor prognosis, mortality, co-morbidities, critical limb ischmemia, amputation, or a potential prognostic biomarker predicting pathological and survival outcomes in thromboangiitis obliterans. We also investigated whether there was any relation between an increased neutrophil/lymphocyte ratio in patients with Buerger’s disease and amputation, the ultimate outcome of poor prognosis. Material and Methods: The hospital records of patients treated, followed-up and diagnosed with thromboangiitis obliterans were analyzed retrospectively. Surgical procedures performed and medical treatments applied were recorded from patients’ clinical data. Extremities exposed to the disease during its course were identified. Amputations were recorded as minor and major. Neutrophil and lymphocyte values were recorded from peripheral blood samples at time of first presentation to hospital, with the neutrophil/ lymphocyte ratio being calculated from these. One hundred ten subjects were finally enrolled as the patient group (TAO; n=110). A control group (n=49) was established consisting of smoker volunteers with no health problems. Statistical changes in neutrophil/ lymphocyte ratio values between the groups were investigated. Results: No statistically significant difference was observed between the two groups’ basic characteristics. In terms of neutrophil/ lymphocyte ratio values, a statistically significant increase was observed in the patient group compared to the control group. We observed no statistical correlation between amputations and neutrophil/lymphocyte ratio values. Conclusions: We think that the neutrophil / lymphocyte ratio, obtained easily and cheaply from routine peripheral blood samples, may be of clinical benefit in thromboangiitis obliterans.
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    N-acetylcysteine reduces oxidative stress on end-organs in an ischemia-reperfusion rat model
    (2020) Altun, Gokalp; Karahan, Suleyman Caner; Pulathan, Zerrin; Yulug, Esin
    Aim: In this study, we researched the effect of N-acetylcysteine (NAC) on parenchymal organs in ischemia-reperfusion injury in the rat models. Material and Methods: Experimental animals divided into four groups: Sham group (Sh, n=6), Sham+NAC group (Sh+NAC, n=6), ischemia-reperfusion group (I/R, n=10) and N-acetylcysteine-given study group (I/R+NAC, n=10). For the Sham group and Sham + NAC group, only aortic exploration was performed. I/R group’s abdominal aortas were clamped just inferior to the renal artery for 4 hours following. Then, the reperfusion period was allowed for one hour. I/R+NAC group received the same procedure as I/R group and additionally treated with NAC intraperitoneally. After these procedures, all rats were sacrificed. The parenchymal organs were excised for biochemical, flow cytometric and histopathologic examination. The data were evaluated statistically.Results: In the I/R+NAC group, the MDA values in AC tissue were significantly lower than the I/R group (p:0.0032). MDA value in kidney tissue was significantly higher in the I/R group compared to the control groups (p:0.003). In the I/R+NAC group, the MDA value was significantly lower than the I / R group (p:0.0002). MPO values in lung tissue were found lower in the I/R+NAC group compared to the I/R group, it was not statistically significant (p:0.4497). In the I/R+NAC group, it was found statistically significantly lower than both the control and I/R groups in Flow cytometric evaluation (p:0.0002). In histopathological evaluation, the leukocyte count observed significantly higher in the I/R+NAC group compared to the control groups and was statistically significantly lower than the I/R group in histopathological evaluation (p:0,0004).Conclusion: NAC reduces ischemia and reperfusion injury in parenchymal organs and especially in the lungs in a rat model.