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    Comparison of neutrophil to lymphocyte ratio and platelet to lymphocyte ratio in patients diagnosed with trigeminal neuralgia and healthy controls
    (2021) Altunisik, Erman; Tak, Ali Zeynel Abidin
    Aim: Trigeminal neuralgia (TN) is a common cranial nerve disease, but its pathogenesis has not yet been fully elucidated. The neutrophil-lymphocyte ratio (NLR) and the platelet-lymphocyte ratio (PLR) have been investigated in recent years as markers of systemic inflammation, and their determination presents as a lower-cost, more practical, and simpler method compared to other inflammation markers. This study aimed to evaluate the possible role of systemic inflammation in TN etiopathogenesis based on NLR and PLR values.Materials and Methods: The study included 55 male and female patients aged 18 to 60 years, who were diagnosed with TN at the Neurology Clinic of our university according to the criteria of Headache Classification Committee of the International Headache Society 2018 (Cephalalgia2018), and 48 healthy controls. Demographic and clinical variables, such as age and gender were retrospectively obtained from medical records.Results: In terms of sociodemographic data, both groups had similar characteristics. The NLR values were 1.84±0.81 for the patient group and 1.92±0.79 for the control group. There was no statistically significant difference in NLR between the two groups (p = 0.447). The PLR values were 101.91±30.24 and 97.84±30.24 for the patient and control groups, respectively, indicating no statistically significant difference (p = 0.439). Conclusions: The role of systemic inflammation in TN pathophysiology remains controversial. It is considered that an inflammatory process may occur in the pathophysiology of TN, but this is characterized by local neurogenic inflammation rather than the effect of a systemic inflammatory response.
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    Do different headache types present with varying MRI findings?
    (2019) Sahin, Sukru; Baykan, Ali Haydar; Altunisik, Erman
    Aim: Studies evaluating the magnetic resonance imaging findings in headache cases mostly focus on migraine and tension headache. In the current study, we aimed to evaluate the possible differences in the magnetic resonance imaging reports between the common headache types presenting with normal neurological findings. Materials and Methods: The magnetic resonance imaging findings of 170 patients aged between 18-45 years that presented with the complaints of headache were retrospectively evaluated. The patients with headaches were divided into the following groups: migraine, tension headache, medication overuse headache, and other headaches (cluster headache, hemicrania continua, paroxysmal hemicrania, trigeminal neuralgia), each consisting of 30 cases. Also, a control group was formed with 50 patients without a headache. The extracerebral, major and minor intracranial abnormalities were noted for all groups. The χ2 test was used to compare the data between the groups.Results: When the patients with headaches were evaluated, clinically silent brain infarct was detected as a major intracranial abnormality only in one patient with trigeminal neuralgia. The incidence of minor abnormalities was higher in the headache groups compared to the controls (p0.05). Conclusion: There was no significant difference between the headache types and the MRI findings. Increased white matter hyperintensity was present in patients with headaches, and especially those with migraine compared to the controls. Keywords: Primary headache; migraine; tension headache; medication overuse.