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Öğe A case of flat wart that responds perfectly to isotretinoin(2019) Ozturk, Murat; An, IsaÖğe A case of isolated macrodactyly(2019) An, Isa; Aksoy, MustafaÖğe Clinical features of patients diagnosed with recidivan cutaneous leishmaniasis(2020) An, Isa; Ozturk, Murat; Aksoy, Mustafa; Yentur, Nebiye; Ayhan, Erhan; Eroglu, NaimeAim: Cutaneous leishmaniasis (CL) is a disease with chronic nodulo-ulcerative lesions on the skin that heals with atrophic scars. This study aims to investigate the clinical features of patients admitted to our clinic and diagnosed as recidivan CL.Material and Methods: This retrospective study included 11 patients who were admitted to our skin and venereal diseases clinic between October 2017 and July 2019 and who were diagnosed as recidivan CL by anamnesis, clinical and microscopic examination. Clinical characteristics of the patients such as age, sex, survival in the endemic region, intralesional or systemic antimony therapy and number, location, size and duration of the lesions were recorded.Results: Seven (63.6%) of the 11 patients were male and 4 (36.4%) were female. The mean age of the patients was 13.8 ± 4.04 years. All of the patients in the study had one lesion on their face. The mean lesion duration was 36.27 ± 24.3 months. The mean lesion size was 6.9 ± 3.4 cm. Before the diagnosis, 2 (18.2%) patients received intralesional antimony treatment, 1 patient (9.1%) received systemic antimony treatment, and 8 (72.7%) patients did not receive any treatment.Conclusion: In conclusion, recidivan CL is a rare form of chronic CL. Because parasites are rare in the lesions, the diagnosis is usually delayed and therefore the lesions can cause destruction and deformity. Prospective studies with a large number of patients are needed to better understand the clinical findings of recidivan CL.Öğe Determination factors of affecting the risks of non-recovery in cutaneous leishmaniasis patients using binary logistic regression(2018) Aksoy, Mustafa; Yesilova, Abdullah; Yesilova, Yavuz; An, IsaAim: This article aimed to make an assessment by applying the binary logistic regression from the studies reported for cutaneous leishmaniasis patients in the province of Şanlıurfa. Material and Methods: The age and sex, the type, localization, diameter and number of lesions as well as treatments of 8000 cutaneous leishmaniasis patients were retrospectively recorded in this study. The risk of non-recovery for intralesional (IL) and intramuscular (IM) groups according to independent variables were assessed using a binary logistic regression. Results: While there was no difference in non-recuperation risk of IL group between genders, males were 39.4% more likely to recuperate than females among the patients belonging to IM groups. All age groups, non-recuperation risk of children were decreased according to the reference level in IL group. As for the IM treatment, non-recovery risk was considered statistically insignificant. During the disease of the patients receiving both IL and IM treatments, non-recuperation risk of the patients of all-week groups was high according to the reference level. When the head and neck region was taken as reference level, the regions with the highest nonrecuperation risk of the lesion for IL and IM was identified as generalized and trunk, respectively. Conclusions: The treatment success rate is inversely proportional with the lesion duration in both IL and IM treatments. There was decreasing in the success rates of both treatments as a result of an increased in lesion size. Increased lesion diameter results in decreased success rates with both treatments.Öğe The effect of COVID-19 on development of hair and nail disorders: a Turkish multicenter, controlled study(Wiley, 2023) Kutlu, Omer; Demircan, Yuhanize Tas; Yildiz, Kenan; Kalkan, Goknur; Demirseren, Duriye Deniz; An, Isa; Oba, Muazzez CigdemBackground A broad spectrum of skin diseases, including hair and nails, can be directly or indirectly triggered by COVID-19. It is aimed to examine the type and frequency of hair and nail disorders after COVID-19 infection. Methods This is a multicenter study conducted on consecutive 2171 post-COVID-19 patients. Patients who developed hair and nail disorders and did not develop hair and nail disorders were recruited as subject and control groups. The type and frequency of hair and nail disorders were examined. Results The rate of the previous admission in hospital due to COVID-19 was statistically significantly more common in patients who developed hair loss after getting infected with COVID-19 (P < 0.001). Telogen effluvium (85%) was the most common hair loss type followed by worsening of androgenetic alopecia (7%) after COVID-19 infection. The mean stress scores during and after getting infected with COVID-19 were 6.88 +/- 2.77 and 3.64 +/- 3.04, respectively, in the hair loss group and were 5.77 +/- 3.18 and 2.81 +/- 2.84, respectively, in the control group (P < 0.001, P < 0.001). The frequency of recurrent COVID-19 was statistically significantly higher in men with severe androgenetic alopecia (Grades 4-7 HNS) (P = 0.012; Odds ratio: 2.931 [1.222-7.027]). The most common nail disorders were leukonychia, onycholysis, Beau's lines, onychomadesis, and onychoschisis, respectively. The symptoms of COVID-19 were statistically significantly more common in patients having nail disorders after getting infected with COVID-19 when compared to the control group (P < 0.05). Conclusion The development of both nail and hair disorders after COVID-19 seems to be related to a history of severe COVID-19.Öğe Evaluation of neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio and mean platelet volume in patients with lichen planus(2019) An, Isa; Ucmak, Derya; Ozturk, MuratAim: In recent years, neutrophil / lymphocyte ratio (NLR), platelet / lymphocyte ratio (PLR) and mean platelet volume (MPV) has been shown to be important indicators of systemicinflammation. Studies have shown that NLR and PLR are higher and that MPV is lower in lichen planus patients compared to the control group. In this study, NLR, PLR and MPV values of lichen planus patients were calculated and investigated whether these parameters were related to nail and oral mucosal involvement. Material and Methods: Eighty one patients with lichen planus without any systemic, infectious and autoimmune disease were included in this study while 81 patients who were admitted to the outpatient clinic for any non-inflammatory condition and whom had blood picture were included in the study as control group. Results: There was no statistically significant difference between neutrophil count, lymphocyte count, leukocyte count, platelet count, NLR and PLR values in LP patients and control group (p> 0.05). MPV value of LP patients had a mean of 8.10 ± 1.40 , and controls had a mean of 7.21 ± 1.45, and the difference was statistically significant (p <0.001). There wasn’t statistically significant relationship between neutrophil count, lymphocyte count, leukocyte count, platelet count, NLR, PLR and MPV values and nail and oral mucosa involvement (p> 0.05). Conclusion: It can be concluded that NLR and PLR were not suitable parameters to show inflammation in LP. The significant higher values of MPV in LP patients suggests that it may be used as a better marker of inflammation in LP patients than NLR and PLR. Nevertheless, the lack of significant association of MPV with nail involvement and oral mucosal involvement may restrict clinical use of it in LP.Öğe The frequency of laryngeal involvement in lipoid proteinosis patients(2019) Aksoy, Mustafa; Yukkaldiran, Ahmet; Yesilova, Yavuz; Demir, Mahmut; Iynen, Ismail; An, Isa; Tanrikulu, OsmanAim: Lipoid proteinosis (LP) is a rare autosomal recessive disorder that occurs with the accumulation of hyaline substance in oral cavity, laryngeal mucosa and skin. The aim of this study was to investigate the incidence of laryngeal involvement in patients with LP which have hoarseness and skin lesions, and the areas of hyaline substance accumulation in the larynx. Material and Methods: In this study, 21 patients who were admitted to our Dermatology outpatient clinic between January 2013 and December 2017 and diagnosed as LP with punch biopsy were evaluated. Laryngeal imaging was performed in otorhinolaryngology clinic, and the frequency of larynx involvement and the areas of hyaline accumulation in the larynx were evaluated. Results: Twenty-one patients with hoarseness and diagnosed by skin biopsy as LP were included in the study. Thickening of the vocal cords in 21 patients (100%); thickening and hypertrophic changes of arytenoids in 13 patients (61.9%); thickening and hypertrophic changes of the interarytenoid area in 10 patients (47.6%); thickeningand hypertrophic changes of epiglottis in 3 (14.3%) patients; hypertrophic changes and thickening of the aryepiglottic fold in 3 patients (14.3%); thickening and hypertrophic changes of ventricular folds in 2 patients (9.5%) were observed. Conclusion: In our study, similar to the data in the literature, the pathological changes were most frequently seen in the vocal cords and the least in the ventricle band, aryepiglottic fold and epiglottis. In order to better understand the laryngeal involvement and the areas of involvement in LP patients, studies with more patients are needed.Öğe Neutrophil / Iymphocyte ratio, platelet / Iymphocyte ratio, mean platelet volume and C-reactive protein values in psoriatic arthritis patients(2019) An, Isa; Ucmak, Derya; Ozturk, Murat; Aksoy, Mustafa; Yildiz, Ismail; Ucan, EgemenAim: Studies have shown that neutrophil / lymphocyte ratio (NLR), platelet / lymphocyte ratio(PLR), mean platelet volume(MPV) and C-reactive protein(CRP) are higher in psoriatic arthritis patients than in the control group. In this study, NLR, PLR and MPV values of patients with psoriatic arthritis were calculated and if these parameters were related to CRP levels. Material and Methods: 74 psoriatic arthritis patients and 77 healthy controls without any systemic, infectious and autoimmune diseases were included in the study. Patients were divided into two groups according to their CRP values: normal (0-0.5 mg / dl) and high (> 0.5 mg / dl) Results: NLR, MPV and CRP values in the patient group were significantly higher than the control group. PLR value in the patient group was higher than the control group but the difference between them was not statistically significant. There was a statistically significant relationship between CRP and NLR and MPV values in psoriatic arthritis patients. Conclusion: Since NLR and MPV were significantly higher in psoriatic arthritis patients than in the control group and there was a statistically significant relationship with CRP elevation, it was thought that they were appropriate parameters to show inflammation in patients with psoriatic arthritis.Öğe Retrospective evaluation of clinical and demographic features of 135 patients with lichen planus(2018) An, Isa; Aksoy, Mustafa; Ozturk, Murat; Celik, HakimAim: Lichen planus (LP) is a chronic, inflammatory, papulosquamous skin disease with different clinical features. The incidence varies according to the geographical regions, although it is seen all over the world and all races. In this study, it was aimed to determine the clinical and demographic characteristics of patients with LP in our clinic. Material and Methods: We included 135 patients who applied to our clinic between January 2013 and December 2017 and who were diagnosed as LP by clinical and histopathological examination and who had HbsAg and Anti HCV tests. Patients’ age, sex, clinical variants of disease, mucosal involvement, nail involvement, HbsAg and Anti HCV tests were retrospectively recorded. Results: Of 135 patients included in the study, 68 (50.4%) were males and 67 (49.6%) females. The mean age of the patients ranged from 18 to 65 years, with a mean of 37.8 ± 12.7 years. Oral mucosal involvement was present in 30 (22.2%) patients and nail involvement in 10 (7.4%) patients. Classical LP was present in 111 of the patients (82.2%). HbsAg positivity was found in 3 of the patients (2.2%), but no anti HCV positivity was detected in any of the patients. Conclusion: The clinical and laboratory characteristics of the LP patients in our study were similar to the literature. More research which includes more patients is needed to better understand the clinical and epidemiological characteristics of LP.
