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Effects of contrast material on the metabolite ratios in single-voxel MR Spectroscopy of intraaxial brain tumors
(Churchill Livingstone, 2012) Alkan, Alpay; Burulday, Veysel; Oztanir, Namik; Dogan, Metin; Erbay, Mehmet Fatih; Kocak, Ayhan; Aralasmak, Ayse
Aim: The purpose of our study was to determine whether the administration of contrast material affects the results of MR Spectroscopy (MRS) in different intraaxial brain tumors. Materials and methods: Thirty-three patients (median range 46.72 +/- 2.95, range 9-77) with intraaxial brain tumors underwent MRS before and 5 min after intravenous administration of gadolinium based contrast material at the standard dose of 0.1 mmol/kg (Gadodiamide or Gd-DOTA). Metabolite ratios (N-acetyl aspartate (NAA)/Creatine (Cr), Choline (Cho)/Cr. and NAA/Cho) were calculated. Results: There was no significant difference between the pre and postcontrast MRS spectra as regards to NAA/Cr (p:0.4), Cho/Cr (p:0.2), and NAA/Cho (p:0.2) ratios obtained from the intraaxial brain tumors. Conclusion: Contrast material administration did not change the metabolite ratios of MRS. Contrast administration would be useful in guiding voxel localization in MRS evaluation of intraaxial brain tumors. (C) 2012 Elsevier Ltd. All rights reserved.