Yazar "Arici, S." seçeneğine göre listele

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    Clinicopathological characteristics of 1005 colorectal cancers in Turkish population: a Turkish gastrointestinal working group study
    (Wiley-Blackwell Publishing, Inc, 2008) Erdamar, S.; Sakiz, D.; Kayaselcuk, F.; Gursan, N.; Ozdamar, S.; Doran, F.; Arici, S.
    [Abstract Not Available]
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    Expression of claudin-4 and ?-catenin in gastric premalignant lesions
    (Univ Catholique Louvain-Ucl, 2009) Seckin, Y.; Arici, S.; Harputluoglu, M.; Yonem, O.; Yimaz, A.; Ozer, H.; Karincaoglu, M.
    Background and study aims : Abnormal expression of claudin-4 and beta-catenin play a role in carcinogenesis. The purpose of the present study was to examine claudin-4 and beta-catenin expression in normal and precancerous gastric mucosa. Patients and methods : Endoscopic biopsy specimens [normal gastric mucosa (n = 22), intestinal metaplasia (n = 24), dysplasia (n = 18), Helicobacter pylori (H. pylori)-associated chronic gastritis (n = 32) and remnant gastric mucosa (n = 18)] obtained from different 114 patients were examined by immunohistochemistry. Results : Claudin-4 expression was present in 94.4% of dysplasia, 87.5% of intestinal metaplasia, 62.5% H. pylori-associated chronic gastritis, and 88.9% remnant gastric mucosa but only 18.2% of normal gastric mucosa biopsies. Decreased expression of beta-catenin was present in 27.8% of dysplasia, 8.3% of intestinal metaplasia, 15.6% of H. pylori-associated chronic gastritis, and 22.2% of remnant gastric mucosa biopsies, but was not present in normal gastric mucosa. When compared with normal gastric mucosa, there was a significant difference in claudin-4 expression in all groups (P < 0.05), but a significant difference was detected in dysplasia and remnant gastric mucosa for beta-catenin (P < 0.05). Conclusions : Our results suggest that claudin-4 expression is upregulated in premalignant gastric alterations. (Acta gastroenterol. belg., 2009, 72, 407-412).