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    Evaluation of epicardial adipose tissue thickness and inflammatory parameters in smokers and non-smokers
    (2022) Soylu, Yasin; Çoşkun, Reşit; Ozcicek, Adalet; Ozcicek, Fatih; Mertoğlu, Cuma; Arslan, Yusuf Kemal
    Smoking is the leading cause of preventable death. Epicardial adipose tissue (EAT) surrounds the heart surface and creates local and systemic effects secreting the hormones, cytokines, inflammatory mediators. Previous studies demonstrated that both smoking and EAT have a strong association with inflammation and atherosclerosis.Our study aimed to determine the relationship of smoking with EAT thickness and inflammation by evaluating smokers and non-smokers. A total of 259 healthy male and female participants between the ages of 18-65, without a history of chronic disease and with a body mass index within normal limits, were included in a study. EAT thickness measurements were made by transthoracic echocardiography and EAT thicknesses of smokers and non-smokers were compared. In addition, the effects of smoking and EAT thickness on different inflammatory parameters were evaluated. When the EAT thicknesses were compared between smokers and non-smokers (2.60±1.2), a statistically significant difference was found in favor of smokers (3.84±1.84) (p<0.001). A moderate positive correlation was found among age, body mass index, smoking duration in years, pack/year and EAT thickness. The difference among waist circumference, the number of cigarettes smoked daily, diastolic blood pressure, fasting blood glucose, ALT, AST, total cholesterol, triglyceride, LDL-cholesterol, CRP, uric acid, platelet count, MPV values, platelet/lymphocyte ratio and EAT thickness were found meaningful, but the weak correlation in different ratios were determined. Smoking was found to be the most important determinant of EAT thickness. Other determinants of EAT thickness were age, body mass index, CRP and female gender. The significant statistical relationship between smoking and EAT thickness suggests that smoking increases EAT thickness and inflammatory parameters. Co-assessment of the EAT and blood inflammatory parameters in smokers may guide the initiation of medical treatment in primary prevention or other therapies.
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    Genotype distribution in Hepatitis C patients admitted to Erzincan Mengücek Gazi Training and Research Hospital
    (2020) Yilmaz, Aysun; Kara, Murat; Karakecili, Faruk; Dabanlioglu, Bulent; Arslan, Yusuf Kemal
    Aim: We aimed to determine the genotype distribution in Hepatitis C patients who Parasitology applied to Erzincan Binali Yildirim University, Mengücek Gazi Training and Research Hospital. Hepatitis C virus, the only member of the genus Hepacivirus of Flaviviridae family, is responsible for 25%-40% of all liver diseases. Hepatitis C virus causes acute hepatitis C and chronic hepatitis C infections. Chronic hepatitis C infection causes cirrhosis, liver failure, hepatocellular cancerand liver diseases in terminal periods. Material and Methods: A total of 77 patients, 41 male and 36 female, who were admitted to Erzincan Binali Yıldırım University, Mengücek Gazi Training and Research Hospital in the period of January 2013-June 2019, were included in our study. RT-PCR and DNA sequencing for the 5’UTR region of the HCV genome for HCV genotyping was performed using the ABI Prism 3130 × 1 DNA Sequencer device.Results: Sex of a total of 77 patients included in the study; 41 of them are men (53.2%) and 36 are women (46.8%). Average age of the patients; It was 59.9 ± 16.6 (minimum 20 and maximum 94). HCV G1b (80.5%) in 62 patients, HCV G1a (7.8%) in 6, HCV G3a (3.9%) in 3, HCV G3 (2.6%) in 2 and HCV G2 (2.6%) was found in 2 patients. HCV G1 (1.3%) was detected in 1, HCV G4 (1.3%) in 1 patient.Conclusion: The dominant genotype in Hepatitis C patients who applied to Mengücek Gazi Training and Research Hospital was determined as “HCV Genotype 1b”.
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    Genotype distribution in Hepatitis C patients admitted to Erzincan Mengücek Gazi Training and Research Hospital
    (2020) Yılmaz, Aysun; Kara, Murat; Karakeçili, Faruk; Dabanlıoğlu, Bülent; Arslan, Yusuf Kemal
    Abstract: Aim: We aimed to determine the genotype distribution in Hepatitis C patients who Parasitology applied to Erzincan Binali Yildirim University, Mengücek Gazi Training and Research Hospital. Hepatitis C virus, the only member of the genus Hepacivirus of Flaviviridae family, is responsible for 25%-40% of all liver diseases. Hepatitis C virus causes acute hepatitis C and chronic hepatitis C infections. Chronic hepatitis C infection causes cirrhosis, liver failure, hepatocellular cancerand liver diseases in terminal periods. Material and Methods: A total of 77 patients, 41 male and 36 female, who were admitted to Erzincan Binali Yıldırım University, Mengücek Gazi Training and Research Hospital in the period of January 2013-June 2019, were included in our study. RT-PCR and DNA sequencing for the 5’UTR region of the HCV genome for HCV genotyping was performed using the ABI Prism 3130 × 1 DNA Sequencer device. Results: Sex of a total of 77 patients included in the study; 41 of them are men (53.2%) and 36 are women (46.8%). Average age of the patients; It was 59.9 ± 16.6 (minimum 20 and maximum 94). HCV G1b (80.5%) in 62 patients, HCV G1a (7.8%) in 6, HCV G3a (3.9%) in 3, HCV G3 (2.6%) in 2 and HCV G2 (2.6%) was found in 2 patients. HCV G1 (1.3%) was detected in 1, HCV G4 (1.3%) in 1 patient. Conclusion: The dominant genotype in Hepatitis C patients who applied to Mengücek Gazi Training and Research Hospital was determined as “HCV Genotype 1b”.
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    Quantification of cell-free DNA from bladder cancer patients after long-term storage and its use in determining CCAT2, HRAS, and RET polymorphism: A pilot study
    (2021) Baydeniz, Soner; Gurbuzel, Mehmet; Sayar, Ilyas; Bozkurt, Aliseydi; Arslan, Yusuf Kemal
    Aim: The level of free DNA is used as a cancer biomarker due to having several advantages related to lower cost, easy applicability, and rapid results compared to invasive methods. Materials and Methods: This study investigated whether or not free DNA functions as intended when stored. The free DNA isolated for this purpose was kept at –80 degrees for four years. Then, the level of free DNA was measured in patients with bladder cancer by both photometric and fluorometric methods, and it was investigated whether this biomarker was effective in determining Single Nucleotide Polymorphisms (SNP). The gene names and the reference numbers of the locations where polymorphism was expected were as follows: CCAT2 (rs6983267), HRAS (rs12628), and RET (rs1799939). Results: According to the results, having the T allele at rs12628 increases the risk of disease by 2.6 times (OR: 2.60; 95% CI: 1.10–6.10) and having the G allele at rs1799939 increases the risk of disease 2.7 times (OR: 2.70; 95% CI: 1.12–6.69). Conclusions: The general findings showed that fluorometric measurements were more advantageous when considering the sensitivity of free DNA measurements. It was also concluded that, if treated rapidly and conserved in appropriate laboratory conditions, free DNA can be effectively used in SNP studies. This study provides important data to demonstrate the quality of free DNA.
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    The Relationship Between Vitamin-D Deficiency and Protein Oxidation Among Obese Children
    (Taylor & Francis Inc, 2023) Surucu Kara, Ilknur; Mertoglu, Cuma; Siranli, Guelsah; Arslan, Yusuf Kemal; Gok, Gamze; Erel, Ozcan
    Aim: The aim of the study is to examine the relationship between obesity, Vitamin-D deficiency, and protein oxidation. Methods: Thiol-disulfide homeostasis, Vitamin-D, ischemia modified albumin, insulin, and lipid levels were compared among obese, pre-obese and normal-weight healthy children. Results: A total of 136 children (69 boys and 67 girls) were included in the study. The vitamin-D levels of obese children were lower than those of pre-obese and normal weight (p < 0.05). In the normal weight group, total thiol and native thiol were lower in the pubertal period than in adolescence; were higher in those with sufficient Vitamin-D level than those with insufficient and deficient Vitamin-D (p < 0.05). Vitamin-D level was lower in pre-obese girls than boys (p < 0.05). Those with high triglycerides had high disulfide/total thiol, disulfide, and disulfide/native thiol and low native thiol/total thiol (p < 0.05). Conclusion: Thiol-disulfide homeostasis is negatively affected by low vitamin D levels, pubertal period and high triglyceride levels.
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    Validation and Cross-cultural Adaptation and Reliability of the Turkish Version of the Michigan Neuropathy Screening Instrument in the Eastern Anatolia Region of Turkey
    (2021) Baday Keskin, Dilek; Duzgun, Eren; Tanoglu, Ceyda; Arslan, Yusuf Kemal
    Aim: Distal symmetric polyneuropathy is a common complication causing foot ulcers and amputations in diabetic patients. The Michigan Neuropathy Screening Instrument (MNSI) is one of the screening methods of diabetic neuropathy, which also provides a comprehensive foot evaluation. The aim of this study was to evaluate the validation, cross-cultural adaptation, and reliability of Turkish Version of the MNSI in the Eastern Anatolia region of Turkey. Materials and Methods: One hundred twenty-six patients with diabetes mellitus were randomly assigned to the study. The questionnaire section of the MNSI was completed by the patients, and the physical examination section was evaluated by health professionals. Nerve conduction studies were performed to 123 patients as the gold standard for diabetic neuropathy. All nerve conduction studies and patients were evaluated by a neurologist. Results: The inter-rater agreement of questionnaire section [ICC: 0.957 (95% CI: 0.940-0.969), p0.001] and physical examination section [ICC: 0.917 (95% CI: 0.884-0.941), p0.001] were excellent. The intra-rater agreement of the questionnaire section [ICC: 0.880 (95% CI: 0.833-0.914), p0.001] and physical examination section [ICC: 0.920 (95% Cl: 0.889-0.943), p0.001] showed a high stability. The area under curve (AUC) for the questionnaire section and physical examination section of the MNSI were 0.588 (p=0.205) and 0.880 (p3, with the sensitivity of 76.2%, specificity of 91.2%, positive predictive value of 64%, negative predictive value of 94.9%.Conclusion: The physical examination section of Turkish version of the MNSI is valid and reliable.