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    Bariatric surgery may exacerbate hyperbilirubinemia in patients with Gilbert s Syndrome
    (2017) Asil, Mehmet; Dertli, Ramazan; Biyik, Murat; Ataseven, Hüseyin; Polat, Hakki; Demir, Ali
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    Bariatric surgery may exacerbate hyperbilirubinemia in patients with Gilbert's Syndrome
    (2017) Asil, Mehmet; Dertli, Ramazan; Bıyık, Murat; Ataseven, Hüseyin; Polat, Hakkı; Demir, Ali
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    Duodenal Varices Diagnosed By Endoscopic Ultrasound: A Case Report
    (2017) Asil, Mehmet; Dertli, Ramazan; Biyik, Murat; Ataseven, Hüseyin; Polat, Hakki; Demir, Ali
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    Neutrophil to lymphocyte ratio is increased in chronic helicobacter pylori infection and returns to normal after successful eradication
    (Turgut Özal Tıp Merkezi Dergisi, 2016) Asil, Mehmet; Dertli, Ramazan
    Abstract Aim: Neutrophil to lymphocyte ratio (NLR) is a useful, low cost marker and it was studied in several diseases. This study was conducted to investigate NLR in chronic Helicobacter pylori infection. Materials and Methods: Clinic and laboratory data of 286 patients with chronic Helicobacter pylori infection and 130 Helicobacter pylori negative controls were analyzed retrospectively. Results: Mean neutrophil to lymphocyte ratio was higher in Helicobacter pylori (+) group than Helicobacter pylori (-) controls (1.98±0.76 vs. 1.64±0.44, p<0.001 respectively) Mean white blood cell and neutrophil counts were also significantly higher in Helicobacter pylori (+) group than Helicobacter pylori (-) controls (7.28±1.55/μL vs. 6.90±1.38 /μL, p=0.011 and 4.27±1.17 /μL vs. 3.82±1.04 /μL, p<0.001 respectively). Lymphocyte count, Hb, Hct, RDW, Plt, MPV, PDW were similar in both groups. 253 patients (88.5%) were given Helicobacter pylori eradication regimen. Post-treatment data were available in 76 (26.6%) patients. Helicobacter pylori, eradication treatment was successful in 45 (59.2%) patients (Group 1) and unsuccessful in 31 (40.8%) patients (Group 2). In group 1, mean pretreatment and post-treatment NLR were 1.99±0.75 and 1.70±0.60 respectively and difference was statistically significant (p=0,004). In group 2 mean pretreatment and post-treatment NLR were 1.93±0.59 and 1.76±0.56 respectively but the difference was not statistically significant (p=0.11). Conclusion: NLR is increased in chronic H.pylori infection and returns to normal after successful H.pylori eradication treatment. Keywords: Neutrophil To Lymphocyte Ratio; Helicobacter Pylori, disease eradication.
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    Serum soluble TWEAK levels in non-alcoholic fatty liver disease
    (2019) Asil, Mehmet; Demir, Ali; Unver, Nurcan; Polat, Hakki; Ataseven, Huseyin; Uysal, Saliha; Kayar, Yusuf; Keskin, Muharrem; Yolacan, Ramazan; Biyik, Murat; Dertli, Ramazan
    Aim: Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease. The exact pathogenesis of NAFLD has not been fully elucidated. Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) is a member of TNF superfamily and it has been implicated in the pathogenesis of several diseases including liver inflammation and fibrosis. Current study was conducted to evaluate serum sTWEAK levels in patients with NAFLD.Material and Methods: Seventeen patients with biopsy proven non-alcoholic steatohepatitis (NASH), 22 patients with simple hepatosteatosis and 30 healthy controls were included in the study and serum sTWEAK concentrations were measured using commercial ELISA kits.Results: Mean serum sTWEAK concentration was significantly lower in the NASH group when compared to the simple hepatosteatosis group and healthy controls (199.6±101.2 pg/mL, 246.1±65.7 pg/mL and 277.6±117.6 pg/mL respectively, p=0.029). ROC analyses for sTWEAK to differentiate NASH patients from healthy controls and from simple hepatosteatosis revealed that AUC for sTWEAK was 0.712 (%95 CI, 0.543-0.880). For the specified cut off value, 171.1 pg/mL positive and negative predictive values calculated were 64.3% and 85.5% respectively. Conclusion: Serum sTWEAK concentration is decreasedin patients with NASH when compared to patients with simple hepatosteatosis and healthy controls. Keywords: Nonalcoholic steatohepatitis; tumor necrosis factor-like weak inducer of apoptosis; sTWEAK; fibroblast growth factor-inducible 14; Fn 14.