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    PHENOLIC CONTENT AND BIOLOGICAL ACTIVITIES OF TRAMETES HIRSUTA
    (Parlar Scientific Publications (P S P), 2021) Akgul, Hasan; Aslan, Ali; Akata, Ilgaz; Gunal, Selami; Bal, Celal; Baba, Hayri
    Natural mushrooms are one of the important elements of the ecosystem. It has been preferred by people from past to present because of its nutritional and medicinal potentials. In this study, antioxidant, oxidant and antimicrobial potential of Trametes hirsuta (Wulfen) Lloyd has been determined. In addition, phenolic compounds in its fruiting body have been scanned. The antioxidant and oxidant potential was determined using Rel Assay kits. Antimicrobial potential was determined using the agar dilution method. Phenolic contents were scanned on the HPLC device. As a result of the studies, the presence of different levels of Gallic acid, Catechin, 4-Hydroxybenzoic acid and Epicatechin were observed in T. hirsuta. TAS value of T hirsuta was determined 3.466 +/- 0.148 mmol/L, TOS value was 13.482 +/- 0.234 mu mol/L and OSI value was 0.390 +/- 0.018. Antimicrobial activity of T. hirsuta was found to be effective at 100, 200 and 400 mu g/mL concentrations. As a result of the studies, it has been determined that T hirsuta has antioxidant and antimicrobial potential.
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    Role of Adenosine Deaminase in Patients with Erythematotelan-giectatic Rosacea and Demodex folliculorum Positivity
    (Iranian Scientific Society Medical Entomology, 2020) Sener, Serpil; Karaman, Ulku; Kiran, Tugba Raika; Colak, Cemil; Aslan, Ali; Direkel, Sahin
    Background: Adenosine deaminase (ADA) is an aminohydrolase involved in the catabolism of purine nucleotides and irreversibly deaminizes adenosine and deoxyadenosine to inosine and deoxyinosine. ADA enzyme deficiency results in the loss of functional properties of B and T lymphocytes. Demodex species have been reported to be transmitted between humans through close contact and to play a role in the pathogenesis of rosacea, acne vulgaris, perioral dermatitis, seborrhoeic dermatitis, micropapillary-pruritic dermatitis and blepharitis. The present study aimed to compare serum ADA levels in D. foaculorum positive patients with the healthy control individuals. Methods: Serum ADA levels were examined for 30 patients diagnosed with erythematotelangiectatic rosacea and 40 healthy individuals in Malatya Inonu University in 2017. Standardized skin surface biopsy (SSSB) method was used to diagnose D. foliculorum. A significant decrease was found in the ADA levels of Demodex-positive rosacea patients when compared to the control group. Results: ADA levels were decreased in the Demodex-positive group. The mean ADA level in patient group was significantly lower than the mean in the control group (P<0.001). There was no significant difference between the patient and control groups in terms of age and gender. Conclusion: During and after treatment of Demodex-positive rosacea patients, determination of ADA levels may give more detailed information on the immune mechanisms.