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    The effect of radiation on antioxidant system of Escherichia coli and radiation resistant deinococcus ra diod ura ns
    (Parlar Scientific Publications, 2019) Ozbey E.; Asma D.
    In last 30-35 years, it has been discovered that many organisms can live in environments consid-ered as extreme for mankind Since these microor-ganisms can live in the extreme environments, they are named as extiemophiles. One of the discovered microorganisms, Deinacaccus radiodurans, had drawn attention for its extraordinary capabilities and its potential of infinity. D. raJiodurans is re-sistant to genotoxic chemicals, oxidative damage, high-level ionization, ultraviolet radiation and de-hydratioa Because of these features one can name it polyextremophilic. In recent years, studies on bioremediation and related to heavy metal and detoxification of xenobiotics which cause serious environment problems, as well as genetic engineering have been intense. However, the reactive oxy-gen species, induced by UV and their effects, their cellular defense mechanisms against ROS and about antioxidative systems responsible for clean-ing of reactive oxygen species enough research has not been made.To this end: In Ecsherichia coli and radiation-resistant D. radiodurans bacteria were compared and tested effects on levels reduced glutathione (GSH) and antioxidant system of radiation. In both bacteria, enzyme activity and GSH levels has been determined after the different doses of ? radiation applications. In the end of our study, high activities in enzyme especially superoxide dismulase and catalase of D. radiodurans were observed depending on the different doses ? radiation applications. We were also observed that GSH quantity and other enzymes had a low activity in the cell. Moreover, it was determined that enzyme and GSH levels were decreased in E. coii depending on the radiation levels. © 2019 Parlar Scientific Publications. All rights reserved.
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    The effects of exogenous adrenomedullin and L-NAME on antioxidant defence system of the hypothalamic-pituitary-adrenal axis and lipid parameters of serum in rat
    (2011) Asma D.; Yuksel S.
    The aim of our study was to investigate the contribution of exogenous adrenomedullin (ADM): an antioxidant, and N sup omega nitro-L- Arginine methyl ester (L-NAME); the nitric oxide synthase (NOS) enzyme inhibitor, to balance the oxidant/antioxidant status in hypothalamus and adrenal medulla, which are both key components of the hypothalamic- Pituitary-adrenal (HPA) axis and affects some lipid metabolic mediators. Thirty six male albino SpraqueDawley rats were randomly divided into three groups: the control group, the ADM group (8 nmol/kg, i.p.), and the L-NAME group (2 ml/kg, i.p.). Measurements of tissue superoxide dismutase (SOD), catalase (CAT), glutathion S-transferase (GST) and glutathion reductase (GR) activities and glutathione (GSH) were performed in tissues using chemical protocols. The biochemical analyses for total lipid, cholesterol, triglycerides, HDL, VLDL, and LDL were conducted on an auto-analyser. Administering exogenous ADM and L-NAME caused synergic changes in the tissues, antioxidative enzyme activities, and altered serum lipoprotein profiles in rats. In the adrenal medulla and hypothalamus of the experimental groups, SOD and GST activities decreased significantly, while the CAT and GR activities increased. The amount of GSH was enhanced in the both tissues in the ADM group only, while the amount was decreased for the hypothalamus of the L-NAME group. After the treatment, the cholesterol (of L-NAME group), triglyceride, total lipid, and VLDL parameters varied significantly, but there was no significant difference between the HDL and LDL among the groups. © by PSP.
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    Response of antioxidant defence system to cadmium-induced toxicity in white rot fungus phanerochaete chrysosporium
    (2010) Yildirim N.; Asma D.
    The effect of different cadmium (Cd) concentrations (5 ?M and 500 ?M) on antioxidant enzymes including superoxide dismutase (SOD, EC 1.15.1.1), catalase (CAT, EC 1.11.1.6), glutathione reductase (GR, EC 1.8.1.7) and glutathione S-transferase (GST, EC 2.5.1.18), and glutathione levels was studied in white rot fungus Phanerochaete chrysosporium (ME446), grown in liquid medium. Exposure to 500 ?M Cd resulted in significant induction of SOD actvity. Exposure to high (500 ?M) and low concentration (5 ?M) led to a clear induction of CAT activity with respect to control group. Exposure to 5 ?M Cd increased GR activity. GST activity was induced but GSH level reduced by exposure to 5 ?M Cd. © by PSP.