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Öğe The acute effect of humic acid on iron accumulation in rats(Biological Trace Element Research, 2016) Çağın, Yasir Furkan; Şahin, Nurhan; Polat, Alaadin; Erdoğan, Mehmet Ali; Atayan, Yahya; Eyol, Ergül; Bilgiç, Yılmaz; Seçkin, Yüksel; Çolak, CemilAbstract Free iron leads to the formation of pro-oxidant reactive oxygen species (ROS). Humic acids (HAs) enhance permeability of cellular wall and act as a chelator through electron transferring. This study was designed to test chelator effect of HA on iron as well as its anti-oxidant effect against the iron-induced hepatotoxicity and cardiotoxicity. The rats used were randomly divided into four groups (n = 8/group): group I (the control group); group II (the HA group), humic acid (562 mg/kg) was given over 10 days by oral gavage; group III (the iron group), iron III hydroxide polymaltose (250 mg/kg) was given over 10 days by intraperitoneal route; and group IV (the HA plus iron group), received the iron (similar to group II) plus humic acid (similar to those in groups II and III) group. Blood and two tissue samples both from liver and heart were obtained for biochemical and histopathological evaluations. Iron deposition, the iron-induced hepatotoxicity, and cardiotoxicity were demonstrated by histopathological and biochemical manner. However, no significant differences were observed in the serum biochemical values and thehistopathological results among the iron and the HA plus iron groups in the liver tissue but not in the heart tissue. The protective effects of humic acid against iron-induced cardiotoxicity were shown but not against hepatotoxicity in our study.Öğe The acute effect of humic acid on ıron accumulation in rats(Biological Trace Element Research, 2016) Çağın, Yasir Furkan; Şahin, Nurhan; Polat, Alaadin; Erdoğan, Mehmet Ali; Atayan, Yahya; Eyol, Ergül; Bilgiç, Yılmaz; Seçkin, Yüksel; Çolak, CemilFree iron leads to the formation of pro-oxidant reactive oxygen species (ROS). Humic acids (HAs) enhance permeability of cellular wall and act as a chelator through electron transferring. This study was designed to test chelator effect of HA on iron as well as its anti-oxidant effect against the iron-induced hepatotoxicity and cardiotoxicity. The rats used were randomly divided into four groups (n = 8/group): group I (the control group); group II (the HA group), humic acid (562 mg/kg) was given over 10 days by oral gavage; group III (the iron group), iron III hydroxide polymaltose (250 mg/kg) was given over 10 days by intraperitoneal route; and group IV (the HA plus iron group), received the iron (similar to group II) plus humic acid (similar to those in groups II and III) group. Blood and two tissue samples both from liver and heart were obtained for biochemical and histopathological evaluations. Iron deposition, the iron-induced hepatotoxicity, and cardiotoxicity were demonstrated by histopathological and biochemical manner. However, no significant differences were observed in the serum biochemical values and the histopathological results among the iron and the HA plus iron groups in the liver tissue but not in the heart tissue. The protective effects of humic acid against iron-induced cardiotoxicity were shown but not against hepatotoxicity in our study.Öğe Acute Fatty Liver of Pregnancy Developing in Early Stages(Turgut Özal Tıp Merkezi Dergisi, 2014) Atayan, Yahya; Çağın, Yasir Furkan; Erdoğan, Mehmet Ali; Aladağ, Murat; Karıncaoğlu, Melih; Harputoğlu, Murat; Seçkin, YükselÖz: Gebeliğin akut yağlı karaciğeri (GAYK) erken tanı konulmadığında ve tedavi edilmediğinde ölümcül seyredebilen gebeliğin nadir ama önemli bir üçüncü trimester komplikasyonudur. GAYK ciddi karaciğer hasarı ile birlikte karaciğer yetmezliği, yaygın damar içi pıhtılaşma (DİK), hepatik ensefalopati, postpartum kanama, çoklu organ yetmezliği ve ölüme yol açabilir. GAYK’de erken tanı ve tedavi ile maternal ve neonatal mortalitenin azalması sağlanabileceğinden her kadın hastalıkları ve doğum hekiminin bu konuda bilgili ve dikkatli olması gerekir. Olguların postpartum dönemde kanama gibi risklerle karşı karşıya olduğu akılda bulunmalıdır. Bu yazıda GAYK hastalığı düşünülen sonrasında DİK ve postpartum ikinci günde karın içi masif kanama gelişen, 36 hafta ikiz gebeliği olan bir olgu sunulması ve literatür eşliğinde olgunun tartışılması amaçlandı.Öğe Albendazole Induced Recurrent Acute Toxic Hepatitis: A Case Report(Univ Catholique Louvain-Ucl, 2017) Bilgic, Yilmaz; Yilmaz, Cengiz; Cagin, Yasir Furkan; Atayan, Yahya; Karadag, Nese; Harputluoglu, Murat Muhsin MuhipIntroduction : Drug induced acute toxic hepatitis can be idiosyncratic. Albendazole, a widely used broad spectrum antiparasitic drug is generally accepted as a safe drug. It may cause asymptomatic transient liver enzyme abnormalities but acute toxic hepatitis is very rare. Case Report : Herein, we present the case of 47 year old woman with recurrent acute toxic hepatitis after a single intake of albendazole in 2010 and 2014. The patient was presented with symptoms and findings of anorexia, vomiting and jaundice. For diagnosis, other acute hepatitis etiologies were excluded. Roussel Uclaf Causality Assessment Method (RUCAM) score was calculated and found to be 10, which meant highly probable drug hepatotoxicity. Within 2 months, all pathological findings came to normal. Result : There are a few reported cases of albendazole induced toxic hepatitis, but at adults, there is no known recurrent acute toxic hepatitis due to albendazole at this certainty according to RUCAM score. Conclusion : Physicians should be aware of this rare and potentially fatal adverse effect of albendazole.Öğe Alkolik Olmayan Yağlı Karaciğer Hastalığı Rekürren Akut Pankreatit için Bir Risk Faktörü müdür?(2020) Kutlu, Orkide; Bilgiç, Yılmaz; Bahri, Evren; Çağın, Yasir Furkan; Atayan, YahyaAmaç: Akut pankreatit (AP), pankreasın oto-digestif, inflamatuar bir hastalığı olup, hastaların dörtte bir kadarında rekürren akut pankreatit (RAP)ataklarıyla karşılaşılabilmektedir. Çalışmamızın amacı, RAP’li hastalarda alkolik olmayan yağlı karaciğer hastalığı (NAYKH) birlikteliğinin AP’lihastalardan farklı olup olmadığını incelemektir.Gereç ve Yöntem: 2014-2017’de AP öntanısıyla gastroenteroloji kliniğine yatırılmış hastalar retrospektif olarak tarandı. Atlanta kriterlerine göre APtanısı konulan ve AP etiyolojisi alkol olmayan toplam 428 hasta çalışmaya dâhil edildi. Birden fazla atak geçiren 40 hasta RAP olarak tanımlandı.Hasta grupları yaş, hemoglobin, platelet, AST, ALT, ALP, GGT, total bilirübin, direkt bilirübin, kalsiyum, TG ölçümleri; kese operasyonu, ERCPişlem sayısı, karaciğer USG ve pankreas USG raporlarına göre istatistiksel olarak karşılaştırıldı.Bulgular: AP’li hastalarda grade I, II ve III yağlanma oranları sırasıyla %8, %10.8 ve %14.6 olup %66.6 hastada steatoz saptanmadı. RAP’li hastalarda grade I, II ve III yağlanma oranları ise sırasıyla %5, %12.5 ve %10 saptandı, %72.5 hastada steatoz saptanmadı. AP ile RAP grupları karşılaştırıldığında hepatobilier USG’de karaciğer yağlanması açısından istatistiksel açıdan anlamlı fark saptanmadı (p =0.761). Hastalarımızda RAP oranı%9.34 olarak bulundu. Her iki hasta grubu arasında değerlendirilen biyokimyasal parametreler içinde sadece TG değerleri RAP grubunda anlamlıyüksekti (p =0,002). Ayrıca RAP grubunda ERCP yapılan hastalar, anlamlı oranda yüksek saptandı (p =0,003).Sonuç: RAP’li hastalarda NAYKH sıklığı AP’li hastalar ile benzer saptandı. AP rekürrensleri etiyolojisinde NAYKH rolünü netleştirmek için bualanda yapılacak yeni çalışmalara ihtiyaç olacaktır.Öğe Ascites and hepatic involvement: a rare and atypical presentation of Burkitt Lymphoma(Turgut Özal Tıp Merkezi Dergisi, 2016) Seçkin, Yüksel; Cagin, Yasir Furkan; Özkan, Ahmet Selim; Bilgiç, Yılmaz; Yıldırım, Oğuzhan; Erdoğan, Mehmet Ali; Atayan, Yahya; Kırımlıoğlu, Hale; Aydoğdu, İsmetAbstract Burkitt lymphoma (BL) is an uncommon form of lymphoma in adults. In this disease, extensive involvement of the omentum and the peritoneum is rare. We present this case with ascites because it is such a rare and overlooked clinical presentation of BL. A previously healthy 20-year-old man was admitted to our hospital with abdominal pain, distension, and night sweats. Physical examination revealed massive ascites. Computerized tomography showed liver metastasis and ascites, but no pathologic thoracal or abdominal lympadenopathy was reported. Atypical lymphocytic cells with cytoplasmic vacuoles were determined on cytologic examination of ascites. We detected starry sky view on the bone marrow examination. On immunophenotyping, cells were CD20 positive, but negative for CD30, CD79a/Tdt. Patient was diagnosed as BL. Burkitt lymphoma should be considered in young patients presenting with ascites and hepatic mass even without lymphadenopathy or focal gastrointestinal masses. Keywords: Ascite; Hepatic İnvolvement; Burkitt Lymphoma.Öğe Ascites and hepatic involvement: a rare and atypical presentation of Burkitt Lymphoma(Turgut Özal Tıp Merkezi Dergisi, 2016) Seçkin, Yüksel; Cagin, Yasir Furkan; Özkan, Melda Çömert; Bilgiç, Yılmaz; Yıldırım, Oğuzhan; Erdoğan, Mehmet Ali; Atayan, Yahya; Kırımlıoğlu, Hale; Aydoğdu, İsmetAbstract Burkitt lymphoma (BL) is an uncommon form of lymphoma in adults. In this disease, extensive involvement of the omentum and the peritoneum is rare. We present this case with ascites because it is such a rare and overlooked clinical presentation of BL. A previously healthy 20-year-old man was admitted to our hospital with abdominal pain, distension, and night sweats. Physical examination revealed massive ascites. Computerized tomography showed liver metastasis and ascites, but no pathologic thoracal or abdominal lympadenopathy was reported. Atypical lymphocytic cells with cytoplasmic vacuoles were determined on cytologic examination of ascites. We detected starry sky view on the bone marrow examination. On immunophenotyping, cells were CD20 positive, but negative for CD30, CD79a/Tdt. Patient was diagnosed as BL. Burkitt lymphoma should be considered in young patients presenting with ascites and hepatic mass even without lymphadenopathy or focal gastrointestinal masses. Keywords: Ascite; Hepatic İnvolvement; Burkitt Lymphoma.Öğe Beneficial effects of dexpanthenol on mesenteric ischemia and reperfusion injury in experimental rat model(Taylor & Francis Ltd, 2016) Cagin, Yasir Furkan; Atayan, Yahya; Sahin, Nurhan; Parlakpinar, Hakan; Polat, Alaadin; Vardi, Nigar; Tagluk, Mehmet EminBackground and aim It has been reported that intestinal ischemia-reperfusion (I/R) injury results from oxidative stress caused by increased reactive oxygen species. Dexpanthenol (Dxp) is an alcohol analogue with epitelization, anti-inflammatory, antioxidant, and increasing peristalsis activities. In the present study, the aim was to investigate protective and therapeutic effects of Dxp against intestinal I/R injury. Materials and methods Overall, 40 rats were assigned into five groups including one control, one alone Dxp, and three I/R groups (40-min ischemia; followed by 2-h reperfusion). In two I/R groups, Dxp (500mg/kg, i.m.) was given before or during ischemia. The histopathological findings including apoptotic changes, and also tissue and serum biochemical parameters levels, were determined. Oxidative stress and ileum damage were assessed by biochemical and histological examination. In the control (n=8) and alone Dxp (n=8; 500mg/kg, i.m. of Dxp was given at least 30min before recording), groups were incised via laparotomy, and electrical activity was recorded from their intestines. In this experiment, the effect of Dxp on the motility of the intestine was examined by analyzing electrical activity. Results In ileum, oxidant levels were found to be higher, while antioxidant levels were found to be lower in I/R groups when compared with controls. Dxp approximated high levels of oxidants than those in the control group, while it increased antioxidant values compared with I/R groups. Histopathological changes caused by intestinal I/R injury and histological improvements were observed in both groups given Dxp. In the Dxp group, electrical signal activity markedly increased compared with the control group. Conclusions Here, it was seen that Dxp had protective and therapeutic effects on intestinal I/R injury and gastrointestinal system peristaltism.Öğe Beneficial effects of dexpanthenol on mesenteric ischemia and reperfusion injury in experimental rat model(Free Radical Research, 2016) Yasir, Furkan Çağın; Atayan, Yahya; Şahin, Nurhan; Parlakpınar, Hakan; Polat, Alaadin; Vardı, Nigar; Tağluk, Mehmet Emin; Tanbek, Kevser; Yıldız, AzibeBackground and aim It has been reported that intestinal ischemia–reperfusion (I/R) injury results from oxidative stress caused by increased reactive oxygen species. Dexpanthenol (Dxp) is an alcohol analogue with epitelization, anti-inflammatory, antioxidant, and increasing peristalsis activities. In the present study, the aim was to investigate protective and therapeutic effects of Dxp against intestinal I/R injury. Materials and methods Overall, 40 rats were assigned into five groups including one control, one alone Dxp, and three I/R groups (40-min ischemia; followed by 2-h reperfusion). In two I/R groups, Dxp (500 mg/kg, i.m.) was given before or during ischemia. The histopathological findings including apoptotic changes, and also tissue and serum biochemical parameters levels, were determined. Oxidative stress and ileum damage were assessed by biochemical and histological examination. In the control (n ¼ 8) and alone Dxp (n ¼ 8; 500 mg/kg, i.m. of Dxp was given at least 30 min before recording), groups were incised via laparotomy, and electrical activity was recorded from their intestines. In this experiment, the effect of Dxp on the motility of the intestine was examined by analyzing electrical activity. Results In ileum, oxidant levels were found to be higher, while antioxidant levels were found to be lower in I/R groups when compared with controls. Dxp approximated high levels of oxidants than those in the control group, while it increased antioxidant values compared with I/R groups. Histopathological changes caused by intestinal I/R injury and histological improvements were observed in both groups given Dxp. In the Dxp group, electrical signal activity markedly increased compared with the control group. Conclusions Here, it was seen that Dxp had protective and therapeutic effects on intestinal I/R injury and gastrointestinal system peristaltism.Öğe The correlation between cytological examination of ascitic fluid and serum ascites albumin gradient in the differential diagnosis of ascites(2019) Atayan, Yahya; Erdogan, Mehmet Ali; Calıskan, Ali Riza; Deviren, Mehmet Veysi; Apak, Ayetullah; Yaslikaya, SendagAim: The accumulation of fluid in pathological quantities in the peritoneal cavity is called ascites. In every newly diagnosed ascites, necessary investigations should be conducted by puncturing ascitic fluid. In this study, we aimed to investigate whether there is any correlation between cytological examination of ascitic fluid and serum ascites albumin gradient (SAAG) in the determination of etiologic causes of ascites. Material and Method: The files of the patients who were admitted to our clinic for the investigation of their ascites etiology between May 2014 and May 2018, were analyzed retrospectively. Pathology reports of the patients whose SAAG was calculated by taking the difference between serum albumin values and simultaneously taken ascitic fluid albumin and whose ascitic fluid cytology examination was performed, were recorded. The data of 248 patients with clinical diagnosis were included in the study. Patients with SAAG <1.1 g / dl and SAAG ≥1.1 g / dl, were divided into two groups. Results: Of the 248 patients included in the study, 114 were female (45.90%) and 134 were male (54.10%) patients. The patients were divided into 2 groups according to SAAG value. In group 1, there were 107 (43.14%) patients with SAAG <1.1 g / dl and in group 2, there were 141 (56.85%) patients with SAAG ≥1.1 g /dl. Group 1: In 70 (28.22%) of 107 patients, positive malignant cytology was consistent with ascites (p<0.0001). In 37 (14.91%) patients, benign cytology ascites was present. Group 2: 133 (53.62%) of 141 patients had benign cytology and 8 (3.23%) had malignant cytology. Conclusion: There was a correlation between malignant cytology of ascites with SAAG <1.1.Öğe The correlation between cytological examination of ascitic fluid and serum ascites albumin gradient in the differential diagnosis of ascites(2019) Atayan, Yahya; Erdoğan, Mehmet Ali; Çalışkan, Ali Rıza; Deviren, Mehmet Veysi; Apak, Ayetullah; Yaslıkaya, SendagAbstract: Aim: The accumulation of fluid in pathological quantities in the peritoneal cavity is called ascites. In every newly diagnosed ascites, necessary investigations should be conducted by puncturing ascitic fluid. In this study, we aimed to investigate whether there is any correlation between cytological examination of ascitic fluid and serum ascites albumin gradient (SAAG) in the determination of etiologic causes of ascites. Material and Method: The files of the patients who were admitted to our clinic for the investigation of their ascites etiology between May 2014 and May 2018, were analyzed retrospectively. Pathology reports of the patients whose SAAG was calculated by taking the difference between serum albumin values and simultaneously taken ascitic fluid albumin and whose ascitic fluid cytology examination was performed, were recorded. The data of 248 patients with clinical diagnosis were included in the study. Patients with SAAG <1.1 g / dl and SAAG ?1.1 g / dl, were divided into two groups. Results: Of the 248 patients included in the study, 114 were female (45.90%) and 134 were male (54.10%) patients. The patients were divided into 2 groups according to SAAG value. In group 1, there were 107 (43.14%) patients with SAAG <1.1 g / dl and in group 2, there were 141 (56.85%) patients with SAAG ?1.1 g /dl. Group 1: In 70 (28.22%) of 107 patients, positive malignant cytology was consistent with ascites (p<0.0001). In 37 (14.91%) patients, benign cytology ascites was present. Group 2: 133 (53.62%) of 141 patients had benign cytology and 8 (3.23%) had malignant cytology. Conclusion: There was a correlation between malignant cytology of ascites with SAAG <1.1.Öğe Ecstasy induced acute hepatic failure. Case reports(Univ Catholique Louvain-Ucl, 2015) Atayan, Yahya; Cagin, Yasir Furkan; Erdogan, Mehmet Ali; Harputluoglu, Muhsin Murat Muhip; Bilgic, Yilmaz3,4-methylenedioxymethamphetamine (MDMA), an amphetamine derivative known as ecstasy, has stimulating and hallucinogenic properties. It has become a substance that is widely used especially by young people. Hepatotoxicity is one of the rare side effects of this substance and can be fatal. Ecstasy-induced fulminant hepatitis has been reported in case reports. The clinical course and the prognosis of the cases may differ. In this article, two cases in whom ecstasy-induced fulminant hepatic failure had developed and who were treated with liver transplantation, and one case which recovered with treatment, have been presented.Öğe Effects of dexpanthenol on acetic acid-induced colitis in rats(Spandidos Publ Ltd, 2016) Cagin, Yasir Furkan; Parlakpinar, Hakan; Vardi, Nigar; Polat, Alaadin; Atayan, Yahya; Erdogan, Mehmet Ali; Tanbek, KevserWhile the pathogenesis of acetic acid (AA)-induced colitis is unclear, reactive oxygen species are considered to have a significant effect. The aim of the present study was to elucidate the therapeutic potential of dexpanthenol (Dxp) on the amelioration of colitis in rats. Group I (n=8; control group) was intrarectally administered 1 ml saline solution (0.9%); group II [n=8; AA] was administered 4% AA into the colon via the rectum as a single dose for three consecutive days; group III (n=8; AA + Dxp) was administered AA at the same dosage as group II from day 4, and a single dose of Dxp was administered intraperitoneally; and group IV (n=8; Dxp) was administered Dxp similarly to Group III. Oxidative stress and colonic damage were assessed via biochemical and histologic examination methods. AA treatment led to an increase in oxidative parameters and a decrease in antioxidant systems. Histopathological examination showed that AA treatment caused tissue injury and increased caspase-3 activity in the distal colon and triggered apoptosis. Dxp treatment caused biochemical and histopathological improvements, indicating that Dxp may have an anti-oxidant effect in colitis; therefore, Dxp may be a potential therapeutic agent for the amelioration of IBD.Öğe Endoscopic treatment of biliary complications in donors after living donor liver transplantation in a high volume transplant center(Aves, 2020) Erdogan, Mehmet Ali; Cagin, Yasir Furkan; Atayan, Yahya; Bilgic, Yilmaz; Yildirim, Oguzhan; Caliskan, Ali Riza; Aladag, MuratBackground/Aims: Although living donor liver transplantation (LDLT) has been accepted as a primary treatment for adults with endstage liver disease, concerns about donor health have emerged. As LDLT is technically complex, it creates perioperative morbidity and mortality risk in donors. Biliary complications such as stricture and leakage are seen most frequently in donors after liver transplantation. While some of these complications get treated with a conservative approach, endoscopic, surgical, and percutaneous interventions may be required in some others. We aimed to present endoscopic retrograde cholangiopancreatography (ERCP) results in donors who developed biliary complications after LDLT. Materials and Methods: Between June 2010 and January 2018, a total of 1521 donors (1291 right lobe grafts, 230 left lobe grafts) who underwent LDLT were retrospectively reviewed. Sixty-three donors who underwent ERCP due to biliary complication were included in the study. Results: Biliary stricture was found in 1.6% (25/1521), biliary leakage in 2.1% (33/1521), and stricture and leakage together in 0.3% (5/1521) donors. Our endoscopic success rates in patients with biliary leakage, biliary stricture, and stricture and leakage were 85% (28/33), 92% (23/25), and 80% (4/5), respectively. Surgical treatment was performed on 12.6% (8/63) donors who failed ERCP. Conclusion: We found that ERCP is a successful treatment for post-LDLT donors who have biliary complications.Öğe Familial alpha 1 antitrypsin deficiency cases that are diagnosed in adulthood(Univ Catholique Louvain-Ucl, 2016) Atayan, Yahya; Cagin, Yasir Furkan; Erdogan, Mehmet Ali; Bestas, Remzi; Aladag, MuratAlpha 1 antitrypsin (AAT) deficiency is a hereditary disorder leading to severe lung and liver diseases worldwide. An accumulation of insoluble heterodimer AAT molecules in hepatocytes is the main cause of liver disorders. The most commonly detected allele worldwide is the PIMM allele, which fulfills the AAT function. The most common missing variant is PiZZ. Serum AAT level is a beneficial but not a reliable determinant for diagnosis. Liver biopsy yields more reliable results. AAT deficiency has no specific treatment. The only treatment modality in children with end stage liver disease is the hepatic transplant. We wanted to present in our article four cases from same family, diagnosed alpha-1 antitrypsindeficiency in adulthood.Öğe The First Finding of Cirrhosis: Hepatic Hydrothorax Caused by Absence of Ascites(2015) Atayan, Yahya; Erdoğan, Mehmet Ali; Çağın, Yasir Furkan; Bilgiç, Yılmaz; Aladağ, Murat; Harputluoğlu, Murat; Karıncaoğlu, MelihHepatic hydrothorax is a pleural effusion occurs in cirrhotic patients without any cardiac and pulmonary disease. Generally it shows up in acidic cases. The most of the cases show up on the right side whereas it rarely shows up on the left and on both sides. Its treatments are salt restriction, diuretic medication and therapeutic thoracentesis. In resistant cases pleurodesis, videothoracoscopic repair of defects, transjugular intrahepatic portosystemic shunt (TIPS) as well as liver transplantation in end stage hepatic cirrhosis patients can be done. In this article, we presented a 54 year old female case with hepatic cirrhosis and hydrothorax without ascites, admitting to clinic because of dyspnea.Öğe Incidence and clinical presentation of portal vein thrombosis in cirrhotic patients(Elsevier Science Bv, 2016) Cagin, Yasir Furkan; Atayan, Yahya; Erdogan, Mehmet Ali; Dagtekin, Firat; Colak, CemilBACKGROUND: Portal vein thrombosis (PVT) is due to many risk factors, but its pathogenesis is still not clearly understood. To identify the risk factors for PVT, we analyzed the clinical characteristics and complications associated with PVT in cirrhotic patients. METHODS: We studied patients with liver cirrhosis who were admitted to our unit from April 2009 to December 2014. The patients were divided into the PVT and non-PVT groups, and were compared by variables including gender, age, the etiology of cirrhosis, stage of cirrhosis, complications, imaging, and treatment. RESULTS: PVT was found in 45 (9.8%) of 461 cirrhotic patients admitted to our hospital. Most patients (45.9%) had hepatitis B virus (HBV)-related cirrhosis, with a similar distribution of etiologies between the groups. However, there was no positive relationship between PVT and etiologies of cirrhosis. Most patients (71.5%) were in the stage of hepatic decompensation. No statistically significant differences were found in complications including esophageal varices, ascites, and hepatic encephalopathy between the groups. However, there was a significant positive correlation between hepatocellular carcinoma (HCC) and PVT (P<0.01). In 30 patients with PVT, thrombosis occurred in the portal vein and/or portal branches, 37.8% were diagnosed on ultrasound. CONCLUSIONS: The incidence of PVT was 9.8%, mainly in patients with HBV-related cirrhosis. The development of PVT was associated with the severity of liver disease and HCC.Öğe Incidence and clinical presentation of portal vein thrombosis in cirrhotic patients(Hepatobiliary & Pancreatic Diseases International, 2016) Çağın, Yasir Furkan; Atayan, Yahya; Erdoğan, Mehmet Ali; Dağtekin, Fırat; Çolak, CemilPortal vein thrombosis (PVT) is due to many risk factors, but its pathogenesis is still not clearly understood. To identify the risk factors for PVT, we analyzed the clinical characteristics and complications associated with PVT in cirrhotic patients. Methods We studied patients with liver cirrhosis who were admitted to our unit from April 2009 to December 2014. The patients were divided into the PVT and non-PVT groups, and were compared by variables including gender, age, the etiology of cirrhosis, stage of cirrhosis, complications, imaging, and treatment. Results PVT was found in 45 (9.8%) of 461 cirrhotic patients admitted to our hospital. Most patients (45.9%) had hepatitis B virus (HBV)-related cirrhosis, with a similar distribution of etiologies between the groups. However, there was no positive relationship between PVT and etiologies of cirrhosis. Most patients (71.5%) were in the stage of hepatic decompensation. No statistically significant differences were found in complications including esophageal varices, ascites, and hepatic encephalopathy between the groups. However, there was a significant positive correlation between hepatocellular carcinoma (HCC) and PVT (P<0.01). In 30 patients with PVT, thrombosis occurred in the portal vein and/or portal branches, 37.8% were diagnosed on ultrasound. Conclusions The incidence of PVT was 9.8%, mainly in patients with HBV-related cirrhosis. The development of PVT was associated with the severity of liver disease and HCC.Öğe Intestinal pseudo-obstruction on the setting of celiac disease: a case report(Turgut Özal Tıp Merkezi Dergisi, 2017) Erdoğan, Mehmet Ali; Cagin, Yasir Furkan; Seçkin, Yüksel; Atayan, Yahya; Bilgiç, YılmazDear Editor, Celiac disease is a disease of small intestines developing in patients with genetic susceptibility after intake of gluten-like proteins. Here, we aim to present a case with intestinal pseudo-obstruction, a rarely seen complication in celiac patientsÖğe Intestinal pseudo-obstruction on the setting of celiac disease: a case report(2017) Erdogan, Mehmet Ali; Cagin, Yasir Furkan; Seckin, Yuksel; Atayan, Yahya; Bilgic, Yilmaz
