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    Rationale, Design, and Methodology of the MORCOR-TURK Trial: Predictors of In-hospital MORtality in CORonary Care Patients in Turkey
    (Kare Publ, 2023) Kahraman, Fatih; Ersoy, Ibrahim; Yilmaz, Ahmet Seyda; Atici, Adem; Tekin, Alpin Mert; Acar, Burak; Kaya, Caglar
    Background: Coronary care units are sophisticated clinics established to reduce deaths due to acute cardiovascular events. Current data on coronary care unit mortality rates and predictors of mortality in Turkey are very limited. The MORtality predictors in CORonary care units in TURKey (MORCOR-TURK) trial was designed to provide information on the mortality rates and predictors in patients followed in coronary care units in Turkey. Methods: The MORCOR-TURK trial will be a national, observational, multicenter, and noninterventional study conducted in Turkey. The study population will include coronary care unit patients from 50 centers selected from all regions in Turkey. All consecutive patients admitted to coronary care units with cardiovascular diagnoses between 1 and 30 September 2022 will be prospectively enrolled. All data will be collected at one point in time, and the current clinical practice will be evaluated (ClinicalTrials.gov number NCT05296694). In the first step of the study, admission diagnoses, demographic characteristics, basic clinical and laboratory data, and in-hospital management will be assessed. At the end of the first step, the predictors and rates of in-hospital mortality will be documented. The second step will be in cohort design, and discharged patients will be followed up till 1 year. Predictors of short- and long-term mortality will be assessed. Moreover, a new coronary care unit mortality score will be generated with data acquired from this cohort. Results: The short-term outcomes of the study are planned to be shared by early 2023. Conclusion: The MORCOR-TURK trial will be the largest and most comprehensive study in Turkey evaluating the rates and predictors of in-hospital mortality of patients admitted to coronary care units.
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    Relationship between platelet-to-lymphocyte ratio and fractional flow reserve in left anterior descending artery with intermediate stenosis
    (2020) Asoglu, Ramazan; Afsin, Abdulmecit; Atici, Adem; Asoglu, Emin
    Aim: Platelet-to-lymphocyte ratio has been used as a determinant factor for coronary artery disease. Since platelet activation is central to the initiation of atherosclerosis, our goal was to evaluate the relationship between platelet-to-lymphocyte ratio and fractional flow reserve (FFR) values in the left anterior descending artery (LAD) with intermediate coronary stenosis.Material and Methods: The present report encompassed 173 subjects having stable angina pectoris. These subjects were categorized into 2 groups: 91 subjects with a FFR less than or equal to 0.80 and 82 patients with a FFR greater than 0.80. The platelet-to-lymphocyte ratio of each subject was determined from the complete blood count. The two groups were evaluated for differences using a Student's unpaired t-test. A p-value of 0.05 was considered statistically significant.Results: The average platelet-to-lymphocyte ratio value of subjects with a FFR less than or equal to 0.80 were significantly higher than those with a FFR greater than 0.80 ((115.5±38.0) vs. (103.8±38.9), p=0.04). The correlation between platelet-to-lymphocyte ratio with stenosis degree was significant (r= 0.22, p= 0.003).Conclusion: Platelet-to-lymphocyte ratio was associated with a FFR measurement of equal or less than to 0.80 in subjects with stable angina pectoris.