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    Urine xanthine oxidase and myeloperoxidase activity in pediatric urinary tract infections
    (2013) Davutoglu M.; Karabiber H.; Kurutas E.B.; Olgar S.; Guler E.; Atli Y.
    Objective: To investigate the relationships between urinary tract infection (UTI), and activity of antioxidant enzymes, xanthine oxidase (XO) and myeloperoxidase (MPO) in urine of children with UTI Design: Prospective observational study Setting: Department of Pediatrics, Kahramanmaras Sutcu Imam University, Faculty of Medicine, Turkey Subjects and Methods: A total of 115 random children admitted to our hospital for urinary symptoms, 61 girls and 54 boys, aged between 2 and 15 years (average 10 years) were included. Study subjects were divided into four groups: Group 1 consisted of 29 pyuria positive and urine culture negative children; Group 2 included 30 children with pyuria and positive urine culture; Group 3 included 26 pyuria negative and urine culture positive children and Group 4 included 30 with pyuria and negative urine culture. Measurement of urine XO and MPO activity were performed spectrophotometrically. Intervension: Urine samples Main Outcome Measures: Antioxidant enzyme activity levels in urine were examined in children with urinary tract infection. Results: Urinary XO activities in Group 2 were significantlyhigher compared with other groups (p < 0.001, p = 0.001 and p < 0.001, respectively). SignificantlydifferentMPOactivitieswere found between Group 1 and Group 2 (p = 0.007). However, no significantdifferencewasfoundbetweenGroup3 and 4. Conclusion: SignificantlyincreasedMPOandXOenzymeactivity was found in children with UTI. Measurement of MPO and XO activity may be useful in children with urinary symptoms to diagnose UTI, before obtaining a positive urine culture.