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Meropenem-Associated Acute Hepatocellular Liver Injury: A Rare Case Report
(Bilimsel Tip Yayinevi, 2026) Salduz, Ekrem; Avcu, Atakan; Kose, Adem; Yilmaz, Zeynep Burcin
Drug-induced liver injury (DILI) is a serious and commonly encountered clinical complication, the diagnosis of which is usually established by exclusion. Antibiotics, particularly beta-lactam agents, are among the leading causes of DILI. Meropenem is a widely used broad-spectrum carbapenem antibiotic. This report presents a case of acute hepatocellular liver injury that developed within 24 hours after initiation of meropenem for the treatment of pneumonia in an 85-year-old patient. Viral hepatitis, autoimmune diseases, and other potential causes of liver injury were comprehensively excluded. In the presence of marked elevations in liver enzymes, meropenem was discontinued, after which the biochemical abnormalities were observed to resolve spontaneously without any specific treatment. Reports of meropenem-induced liver injury are rare in the literature; the rapid onset and reversibility observed in this case underscore the importance of drug discontinuation in management. In clinical practice, awareness of the risk of hepatotoxicity associated with meropenem use and adoption of a multidisciplinary approach in similar cases are of great importance.