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    Amygdalin in bitter and sweet seeds of apricots
    (Taylor & Francis Ltd, 2014) Karsavuran, Nazan; Charehsaz, Mohammad; Celik, Hayati; Asma, Bayram Murat; Yakinci, Cengiz; Aydin, Ahmet
    Hydrogen cyanide (HCN) poisoning due to amygdalin (AMY) in apricot seeds is one of the public health issues in Turkey. The aim of this study was to investigate the AMY content of 13 different apricot seeds including bitter and sweet ones, and which are either sulfurized or roasted. The AMY content was determined by a high-performance liquid chromatography. Release of HCN was predicted and total amount of seeds which can cause poisoning was calculated. The mean AMY content of bitter seeds was 26 +/- 14 mg g(-1) and that of sweet seeds was 0.16 +/- 0.09 mg g(-1). The consumption of small amounts of bitter seeds may cause cyanide poisoning.
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    Evaluation of balance with video head impulse test and vestibulospinal tests in patients with substance use disorder
    (2022) Aydin, Ahmet; Kutluhan, Ahmet; Sahiner, Safak; Kaya, Sule
    Aim: The aim of this study was to investigate the long-term complications of substance use on the vestibular system. Substance use disorders are thought to impair the vestibular apparatus as well as the auditory system. Materials and Methods: Sixty-five cases with a history of non-alcohol drug addiction who survived the withdrawal phase and 22 healthy controls were included in the study. The cases were categorized into 2 different subgroups as those who had used only opioids ("opioid") and those who had used an opioid and chemical simultaneously or otherwise ("opioid &chemical"). Vestibulospinal tests and video Head Impulse Test (vHIT) were performed on all participants and the results were analyzed. Results: A total of 65 (61 males/4 females, mean age was 25 ± 3.95 years) cases and 22 (males, mean age was 25 ± 3.3 years) healthy controls were included in the study. The mean age of the "opioid" group (n=33) was 25 ± 3.95 years, and the mean age of the "opioid & chemical" group (n=32) was 25 ± 3.13 years (p>0.05). When the cases and controls were evaluated according to vestibulospinal tests, a high level statistically significant difference was observed (p<0.001), but no significant difference was found according to vHIT. Conclusion: This is the first study evaluating long-term vestibular functions with the vHIT test in patients with substance use disorder. Although the results suggest that there is no vestibulo-ocular reflex (VOR) involvement in the groups according to the vHIT, it has been revealed that substance use has negative effects on balance and walking.
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    A Guidance Manual for the Toxicity Assessment of Traditional Herbal Medicines
    (Natural Products Inc, 2016) Aydin, Ahmet; Aktay, Goknur; Yesilada, Erdem
    Herbal remedies have been used for thousands of years in worldwide traditional medicines for their potential health benefits. Although they are generally presumed safe unless a significant risk has been identified in humans, increasing number of case reports notify acute or chronic intoxications resulting from their use. This study aims to produce a scientific guide for the evaluation of traditional herbal medicines (THMs) in terms of their toxicity risks based on the published regulatory documents. For this purpose recommended in vitro and in vivo toxicity tests on medicinal products for human use issued by the international regulatory bodies are overviewed and they are then adopted to be used for the toxicity assessment of THMs. Accordingly, based on compilation of these issued regulations, the following tests are recommended for the toxicity assessment of THMs; in vitro cytotoxicity, genotoxicity, acute and repeated dose toxicity, carcinogenicity, reproductive and developmental toxicity, local tolerance tests, toxicokinetic studies, and additional toxicity tests including safety pharmacology, immunotoxicity and antigenicity, endocrine system toxicity, gastro-intestinal toxicity, renal and hepatotoxicity, and drug interaction studies. This study describes and discusses the applicability of these tests for the risk assessment in THMs.
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    Intensive Care Unit Admission Predictors of Geriatric Patients Who Underwent Hemiarthroplasty due to Hip Fracture
    (Turkish Soc Medical & Surgical Intensive Care Medicine, 2021) Miniksar, Okkes Hakan; Kacmaz, Osman; Yuksek, Ahmet; Aydin, Ahmet; Oz, Hakan
    Objective: In this study, we aimed to investigate the clinical features of geriatric hip fracture cases that underwent hemiarthroplasty surgery and to reveal the predictors of hospitalization in ICU accordingly. Methods: In this study, 158 geriatric patients who underwent hemiarthroplasty surgery for femoral neck fracture between January 2017 and December 2019 were retrospectively analyzed. The patients were divided into two groups as patients who were admitted to the ICU (ICU) and patients who were not admitted to the ICU (non-ICU). The clinical characteristics of the patients were compared between the two groups, and predictors of ICU admission were determined by a multivariate regression model. Results: The mean age of the patients was 82.16 +/- 7.5 years, the mean duration of ICU hospitalization was 1.98 +/- 1.4 days, and the mortality rate was 9.5%. One hundred nineteen of the patients (75.31%) were admitted to the ICU after the surgery.According to the results of the univariate regression analysis, advanced age, presence of comorbidities (coronary artery disease, cerebrovascular disease), number of comorbidities, ASA score, Charlson age-corrected comorbidity index, transfusion of erythrocyte suspension, and cement application were significant risk factors for admission to ICU (p<0.02 for each). According to multivariate regression analysis, ASA score (OR=2.77, p=0.04) and cement application (OR=5.97, p<0.001) were determined as independent risk factors for hospitalization in ICU. Conclusion: Factors that are predictors of the need for ICU after hemiarthroplasty surgery (ASA score and cement application) should be considered in geriatric patients. More comprehensive research is required to show the potential effects of these predictors better.
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    Morbidity and mortality results of COVID-19 variant in COVID-19 positive patients treated in the intensive care unit
    (Bayrakol Medical Publisher, 2023) Aydin, Ahmet; Koca, Erdinc; Kutlusoy, Sevgi; Kasapoglu, Umut Sabri
    Aim: COVID-19 has the potential to affect many systems and organs, resulting in serious clinical symptoms that necessitate admission to the intensive care unit. The purpose of this study was to examine the relationship between CAR, other laboratory findings, comorbidities, and mortality in patients infected with the original SARSCoV-2 or other variants.Materials and Methods: The data of 368 patients admitted to the intensive care unit with COVID-19 pneumonia between March 2020 and July 2021 were analyzed. These patients were divided into two groups. The first group included [(OC) Original SARSCoV-2 ] COVID-19 infected patients in the first period of the pandemic. The second group [(OV) Other Variants] included patients with COVID-19 infection due to other variants.Results: The mean age (Mean +/- SD) in the OC group was 69.79 +/- 11.77 years. The mean age of the patients in OC was higher than in the OV group (p=0.001). The most common comorbid disease in both groups was Hypertension (54.1%, 48.8%), followed by diabetes mellitus (DM) (30.2%, 31.6%). The mean age of the survivors in the OC and OV groups was lower (64.53 +/- 13.04, 57.85 +/- 16.78, p=0.001, p=0.001, respectively). It was observed that albumin and lymphocyte counts were lower in the deceased, while LDH, CRP, Neutrophil, procalcitonin, NLR and CAR were higher (p<0.05). Discussion: In critically ill COVID-19 patients, high CAR and NLR are good predictors of mortality. In the period when the variants were dominant, the mean age of the patients and the length of stay in the intensive care unit were lower.
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    PROGNOSIS OF GERIATRIC COVID-19 PATIENTS ADMITTED TO INTENSIVE CARE UNIT ACCORDING TO VACCINATION STATUS
    (Gunes Kitabevi Ltd Sti, 2022) Aydin, Ahmet; Kacmaz, Osman; Koca, Erdinc; Kutlusoy, Sevgi; Kasapoglu, Umut Sabri; Oterkus, Mesut
    Introduction: As of June 27, 2022, the COVID-19 pandemic has caused over 540 million infections and 6.3 million deaths. We aimed to investigate the effect of the vaccine on the clinical course of elderly patients hospitalized in the intensive care unit and to determine the prognosis of the patients according to their vaccination status. Materials and Methods: The study included 157 patients over the age of 65. Patients were divided into two groups. The first group consisted of patients who were vaccinated with two doses of CoronaVac, and the second group consisted of patients who were not vaccinated. Demographic data of the patients, prehospital clinical frailty scales, Charlson Comorbidity Indexes, APACHE II scores, laboratory values, and patient prognoses were recorded. Results: Of the 157 patients, 93 (59.2%) were female, and the median age was 76 years (65-99). 96 (61.1%) patients were vaccinated and 61 (38.9%) patients were unvaccinated. Patients were grouped as survivors (n=26) and deceased. We found that APACHE II, prehospital clinical frailty scales, and Charlson Comorbidity Indexes scores were higher in patients who died. There was a significant difference between blood lymphocyte and ferritin levels and survival. The 28-day survival rate was higher and intensive care unit overall survival time were longer in the vaccinated group. Conclusions: We observed that the vaccinated patients had higher survival times and lower mortality rates than those who were not vaccinated. We think that it is important to vaccinate elderly patients and that additional doses may be needed.