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Öğe Capsaicin Reduces Kidney Injury in a Sepsis Model Induced by Cecal Ligation and Puncture(Wiley, 2025) Bircan, Burak; Firat, Semanur; Cakir, Murat; Sekerci, Guldeniz; Oz, Samet; Aydin, Ali[No abstract available]Öğe Effect of KML29 and URB597 on Renal Ischemia Reperfusion Injury in Rats(Wiley, 2023) Cakir, Murat; Aydin, Ali; Tekin, Suat[Abstract Not Available]Öğe Evaluation of the time-dependent effect of an enzymatic denture cleanser tablet against six microbial species(2019) Hayran, Yeliz; Aydin, AliAim: In elderly individuals, infection control is, essential, especially in the presence of severe bacteria such as oral environment. Prevention of biofilm formation in removable dental prosthesis, which is often used in elderly patients might help infection control. This study aimed to evaluate the time-dependent effect of an enzymatic tablet on six microorganisms cultured in two different denture base resins.Material and Methods: Polymethylmethacrylate (PMMA) and polyamide-resin were used in this study. 480 samples were prepared for each resin, and denture cleanser tablet was tested against C.albicans, S.mutans, S.gordonii, A.actinomycetemcomitans, S.aureus, and E.coli for 3rd, 5th, 10th, 20th, 40th, 80th, 160th, and 200th minutes. Cell viability (CV) was evaluated by MTT. ANOVA was used for statistics. Results: C.albicans exhibited higher CV in polyamide-resin compared to PMMA-resin in all tested durations. S.gordonii and A.actinomycetemcomitans exhibited higher CV in PMMA-resin except for 80th minute-S.gordonii, which had similar values. S.mutans had a higher CV in PMMA-resin than polyamide-resin at 3rd, 5th, 10th, 160th, and 200th minutes, and other values were similar to polyamide-resin. The tested concentration killed more than 75% of microorganisms except for 3rd and 5th minute-C.albicans on resins. S.aureus and E.coli had similar. CV of microorganisms on PMMA-resin was higher than on polyamide-resin. All microorganisms exhibited different adherence on the resins.Conclusions: Tablet cleanser was effective in all microorganisms and durations and over 10-minute durations provided over 76% cell death. Patients with a compromised immune system can safely use restorations composed of polyamide-resin or PMMA-resin with 40 min-treatment of tablet cleanser.Keywords: Bacteria; candida albicans; cell survival; denture bases; denture cleansers.Öğe High-fructose corn syrup causes vascular dysfunction associated with metabolic disturbance in rats: Protective effect of resveratrol(Pergamon-Elsevier Science Ltd, 2012) Akar, Fatma; Uludag, Orhan; Aydin, Ali; Aytekin, Yasin Atacan; Elbeg, Sehri; Tuzcu, Mehmet; Sahin, KazimHigh-fructose corn syrup (HFCS) is used in many prepared foods and soft drinks. However, limited data is available on the consequences of HFCS consumption on metabolic and cardiovascular functions. This study was, therefore, designed to assess whether HFCS drinking influences the endothelial and vascular function in association with metabolic disturbances in rats. Additionally, resveratrol was tested at challenge with HFCS. We investigated the effects of HFCS (10% and 20%) and resveratrol (50 mg/l) beverages on several metabolic parameters as well as endothelial relaxation, vascular contractions, expressions of endothelial nitric oxide synthase (eNOS), sirtuin 1 (SIRT1), gp91(phox) and p22(phox) proteins and superoxide generation in the aortas. Consumption of HFCS (20%) increased serum triglyceride, VLDL and insulin levels as well as blood pressure. Impaired relaxation to acetylcholine and intensified contractions to phenylephrine and angiotensin II were associated with decreased eNOS and SIRT1 whereas increased gp91(phox) and p22(phox) proteins, along with provoked superoxide production in the aortas from HFCS-treated rats. Resveratrol supplementation efficiently restored HFCS-induced deteriorations. Thus, intake of HFCS leads to vascular dysfunction by decreasing vasoprotective factors and provoking oxidative stress in association with metabolic disturbances. Resveratrol has a protective potential against the harmful consequences of HFCS consumption. (C) 2012 Elsevier Ltd. All rights reserved.Öğe Inhibition of Transient Receptor Potential Ankyrin 1 Channels Reduces Renal Ischemia Reperfusion Injury(Wiley, 2025) Firat, Semanur; Cakir, Murat; Bircan, Burak; Aydin, Ali; Sekerci, Guldeniz; Oz, Samet[No abstract available]Öğe JAK inhibitor Baricitinib Attenuates Kidney Injury in Sepsis Model Induced by Cecal Ligation and Puncture(Wiley, 2025) Tarakci, Betul; Firat, Semanur; Cakir, Murat; Bircan, Burak; Sekerci, Guldeniz; Aydin, Ali[No abstract available]Öğe JAK1/JAK2 inhibitor baricitinib ameliorates sepsis-induced acute kidney injury in rats(Elsevier, 2025) Cakir, Murat; Tarakci, Beti; Aydin, Ali; Bircan, Burak; Firat, Semanur; Sekerci, GildenizBackground: Baricitinib (Bar), used in the management of rheumatoid arthritis, is a selective inhibitor of JAK1/ JAK2. Studies have shown that it inhibits the intracellular signaling of many proinflammatory cytokines by suppressing STAT3 activation. Increased expression and activity of JAK1/JAK2 and STAT3 are associated with kidney damage. Here, we examined the effects of the JAK1/JAK2 inhibitor baricitinib (Bar) on kidney damage in a sepsis model created with cecal ligation and puncture (CLP) in rats. Methods: Rats were divided into four groups: control, CLP, CLP + Bar 3 mg kg- 1, and CLP + Bar 10 mg kg- 1. The cecum of animals to which CLP was applied was first ligated distally, then punctured with a needle to allow the fecal content to spread into the abdominal cavity. Two different doses of Bar (3 mg kg- 1, 10 mg kg- 1) were applied to the treatment groups. Biochemical examinations were performed on the sera of animals sacrificed 24 h after CLP, while histopathological and immunohistochemical examinations were performed on kidney tissue. ResultsÖğe Protective effect of fatty acid amide hydrolase inhibitor URB597 and monoacylglycerol lipase inhibitor KML29 on renal ischemia-reperfusion injury via toll-like receptor 4/nuclear factor-kappa B pathway(Elsevier, 2023) Cakir, Murat; Aydin, Ali; Tekin, SuatBackground: Arachidonoyl ethanolamide (anandamide, AEA) and 2-arachidonoylglycerol (2-AG) are the most studies endocannabinoids. AEA and 2-AG are degraded by fatty acid amide hydrolase (FAAH) and mono-acylglycerol lipase (MAGL) enzymes, respectively. FAAH and MAGL enzymes are widely expressed in many tissues, including kidney. Recent works have depicted that AEA and 2-AG levels are associated with ische-mia-reperfusion (IR) injury. In this study, we investigated the effects of MAGL inhibitor KML29 and FAAH in-hibitor URB597 against kidney IR injury.Methods: The kidneys of the rats underwent ischemia for 45 min and then reperfusion for 24 h. KML29 and URB597 were administered intraperitoneally with kidney IR to two different treatment groups. Results: IR application increased serum blood urea nitrogen (BUN), creatinine (Cre), interleukin-18 (IL-18), neutrophil gelatinase-associated lipocalin (NGAL), and kidney injury molecule-1 (KIM-1) levels, while these parameters were decreased following KML29 and URB597 administration. KML29 and URB597 administration also reduced the increased toll-like receptor-4 (TRL-4), phosphorylated-NF-kappa B, phosphorylated-I kappa B-alpha, tumor necrosis factor alpha (TNF-alpha), interleukin-1beta (IL-1 beta), interleukin-6 (IL-6), caspase-3 levels and histopatho-logical damage in kidney tissue.Conclusions: Our results reveal that MAGL inhibitor KML29 and FAAH inhibitor URB597 have a protective effect on kidney IR injury by preventing apoptosis and inflammation. Inhibition of MAGL and FAAH may be a new therapeutic strategy to prevent kidney IR injury.Öğe Protective Effect of Pomegranate Juice on Lead Acetate-Induced Liver Toxicity in Male Rats(Pera Yayincilik Hizmetleri, 2024) Pekmez, Hidir; Annac, Ebru; Bulmus, Ozgur; Zencirci, Buesra; Aydin, Merve; Aydin, AliObjective: Lead has been reported to cause oxidative stress in liver tissues and cause histopathological changes. Studies have shown that pomegranate juice has antioxidant properties that prevent oxidative stress. In this study, the harmful effects of lead acetate on rat liver tissue and the efficacy of pomegranate juice against these effects were investigated. Methods: 28 male Wistar albino rats were divided into four groups: control, lead acetate (50 mL/ kg), pomegranate juice (1 mL/kg), and lead acetate + pomegranate juice (50 mL/kg+1 mL/kg). Lead acetate and pomegranate juice were administered orally. Results: When compared with the control group, it was seen that the lead acetate had an increase in the malondialdehyde level and a decrease in reduced Glutathione, Glutathione S-transferase, and Carboxylesterases. Group lead acetate + pomegranate juice had a reduction in malondialdehyde level and an increase in Glutathione, Glutathione S-transferase, and Carboxylesterases compared with the group lead acetate. The lead level of group lead acetate + pomegranate juice decreased compared to the group lead acetate. Cellular degeneration and irregular hepatic cords were observed in group lead acetate's liver tissue, and the negative changes were lost in group lead acetate + pomegranate juice. Conclusion: It was observed that pomegranate juice had a protective effect against liver toxicity caused by lead acetate.Öğe Protective Effect of Transient Receptor Potential Ankyrin 1 Inhibition on Renal Ischemia Reperfusion Injury in Rats(Wiley, 2025) Cakir, Murat; Aydin, Ali; Firat, Semanur; Sekerci, Guldeniz; Bircan, Burak; Oz, SametThe transient receptor potential ankyrin 1 (TRPA1) channels, characterized as nonselective cation channels with permeability to calcium ions (Ca2 +), are part of the extensive family of transient receptor potential (TRP) channels. Research has demonstrated that TRPA1 channels function as sensors for oxidative stress in the renal tubules. Additionally, TRPA1 expression has increased in renal tissue following ischemia-reperfusion (IR). There is also a significant correlation between IR-induced renal injury and TRPA1 expression. This study investigated the effects of selective TRPA1 agonist ASP7663 and selective TRPA1 antagonist HC-030031 on renal IR injury. A total of 40 rats were divided into four groups: control, IR, IR+ASP7663, and IR + HC-030031. The rat kidneys were exposed to 45 min of ischemia, followed by 24 h of reperfusion. TRPA1 agonist ASP7663 and selective TRPA1 antagonist HC-030031 were administered intraperitoneally to the treatment groups with renal IR. HC-030031 administration reduced the elevated kidney injury molecule-1 (KIM-1), blood urea nitrogen (BUN), and creatinine (Cre) caused by renal IR. HC-030031 administration reduced the increased histopathological damage in renal tissue due to IR. It also reduced renal tissue interleukin-1beta (IL-1 beta), interleukin-6 (IL-6), toll-like receptor-4 (TLR-4), phosphorylated-NF-kappa B, phosphorylated-I kappa B-alpha, tumor necrosis factor-alpha (TNF-alpha), and caspase-3 levels. In this study, TRPA1 antagonist HC-030031 showed a protective behavior on renal IR injury by averting inflammation and apoptosis. After further studies, TRPA1 inhibition may be a new treatment strategy to prevent renal IR injury.Öğe The protective effects of pomegranate juice on lead acetate-induced neurotoxicity in the male rat: A histomorphometric and biochemical study(Wiley, 2022) Annac, Ebru; Uckun, Mirac; Ozkaya, Ahmet; Yologlu, Ertan; Pekmez, Hidir; Bulmus, Ozgur; Aydin, AliThe purpose of this study was to investigate the potential side-effects of lead acetate (LA), which is toxic to the nerves, blood and muscles, in the rat brain. The neuroprotective effects of pomegranate juice (PJ) against LA exposure were also observed. The experiment involved 28 male Wistar albino rats aged 12 weeks. These were divided into four groups: Control, PJ, LA and LA+PJ. Stereological techniques were employed to determine hippocampal volume in each rat brain. Biochemical investigations and histopathological examinations were also performed. Analysis demonstrated a significant decrease in hippocampal volume in the LA group compared to the control group (p < .05). The stereology results also indicated that PJ has protective effects when compared with the LA and LA+PJ groups. A significant increase was also determined in malondialdehyde (MDA) levels and glutathione S-transferase (GST) activity in the LA group compared to the control group, in contrast to glutathione (GSH) levels and carboxylesterase (CaE) and acetylcholinesterase (AchE) activities. MDA and GST activity decreased significantly in the LA+PJ group compared to the LA group in contrast to GSH levels and CaE and AchE activities. Histopathological examination revealed a number of degenerative changes in the LA group. Exposure to LA adversely affects the hippocampus on the male rat brain. It might also be suggested that PJ may ameliorate these deleterious effects.Öğe Protective Effects of TRPV1 Agonist Capsaicin in Sepsis-Induced Acute Kidney Injury in Rats(Wiley, 2025) Bircan, Burak; Cakir, Murat; Aydin, Ali; Firat, Semanur; Sekerci, Guldeniz; Samet, Oz; Tekin, SuatTransient receptor potential vanilloid-1 (TRPV1) channels have been shown to be present in many tissues, including the kidney. Previous studies have reported that TRPV1 activation has anti-inflammatory and renoprotective effects. In this study, we investigated the effects of TRPV1 agonist capsaicin on acute kidney injury (AKI) in a rat sepsis model induced by cecal ligation and puncture (CLP). Rats were divided into control, CLP and treatment groups in which 3 different doses of capsaicin (2, 6 and 30 mg/kg) were administered with CLP administration. Kidney tissues and sera from animals 24 h after CLP were analyzed. Histopathological examinations have shown that kidney damage occurs due to sepsis. TLR4/NF-kappa B activity, proinflammatory cytokines (IL-1 beta, IL-6, and TNF-alpha), caspase-3, caspase-8 and malondialdehyde levels increased in renal tissue due to sepsis. Serum levels of IL-1 beta, TNF-alpha and renal damage biomarkers (BUN, CRE, IL-18 and NGAL) increased due to sepsis. Capsaicin administration dose-dependently reversed sepsis-induced pathological changes in the kidney and serum. Our findings suggest that the TRPV1 agonist capsaicin has renoprotective effects in sepsis-induced AKI by reducing inflammation, oxidative damage and apoptosis. TRPV1 activation may be a promising therapeutic strategy to ameliorate sepsis-induced kidney and other organ damage.Öğe The ameliorative effect of inhibiting transient receptor potential ankyrin 1 on sepsis-induced kidney injury via the toll-like receptor 4/nuclear factor-kappa B pathway(Elsevier, 2025) Firat, Semanur; Cakir, Murat; Aydin, Ali; Bircan, Burak; Sekerci, Guldeniz; Tekin, SuatBackground Kidneys are among the organs most affected by sepsis caused by the host's uncontrolled immune response to infection. Transient receptor potential ankyrin 1 (TRPA1) channels have been shown to be associated with renal damage. TRPA1 channels also have a role in regulating intracellular Ca2+ levels, cytokine production, and immune response control. In this study, the effects of TRPA1 agonist ASP7663 and antagonist HC-030031 on renal injury in an experimental sepsis model were examined. Materials and methods Rats underwent cecal ligation and perforation (CLP) to serve as an experimental sepsis model. One of the two treatment groups received a TRPA1 agonist ASP7663, while the other received a TRPA1 antagonist HC030031. Serum levels of BUN, creatinine (Cre), TNF-alpha, IL-1 beta, IL-18, neutrophil gelatinase-associated lipocalin (NGAL), and kidney injury molecule-1 (KIM-1) were measured. Histopathological examination of kidney tissue was performed. Immunohistochemical analysis of Toll-like receptor 4 (TLR4), NF-kappa B, phosphorylated NF-kappa B, I kappa B-alpha, phosphorylated I kappa B-alpha, TNF-alpha, IL-1 beta, IL-6, caspase-3, and caspase-8 levels was conducted in kidney tissue. Results CLP administration raised serum levels of BUN, Cre, TNF-alpha, IL-1 beta, IL-18, NGAL, and KIM-1 (P < 0.05). It also caused histopathological damage to kidney tissue. Additionally, CLP increased levels of TLR4, phosphorylated NF-kappa B, phosphorylated I kappa B-alpha, TNF-alpha, IL-1 beta, IL-6, caspase-3, and caspase-8 in kidney tissue (P < 0.05). The TRPA1 antagonist HC-030031 reversed all pathological changes in serum and kidney tissue caused by CLP. Conclusion TRPA1 antagonist HC-030031 showed a protective effect in an experimental sepsis model by reducing kidney damage through its anti-inflammatory and anti-apoptotic effects.Öğe The Effect of Sulfasalazine on Renal Damage in Sepsis Model Induced by Cecal Ligation and Puncture in Rats(Wiley, 2025) Cicek, Zeynep; Cakir, Murat; Aydin, Ali; Bircan, Burak; Firat, Semanur; Tekin, SuatSepsis is a medical condition that occurs when a harmful inflammatory response damages tissues and organs. The kidneys are among the organs most frequently affected by sepsis. Anti-inflammatory strategies are crucial in treating sepsis. The anti-inflammatory properties of sulphasalazine (SFZ) have been demonstrated in various in vitro and in vivo studies. This study investigates the effect of SFZ on kidney damage in a rat model of sepsis induced by the cecal ligation and puncture (CLP) method. Animals were divided into control, CLP, CLP + SFZ50, and CLP + SFZ250. Two doses of SFZ (50 and 250 mg/kg) were applied in two different treatment groups after CLP. The administration of SFZ reduced the CLP-induced increase in serum blood urea nitrogen (BUN), tumor necrosis factor-alpha (TNF-alpha), interleukin-1 beta (IL-1 beta), neutrophil gelatinase-associated lipocalin (NGAL), interleukin-18 (IL-18), kidney injury molecule-1 (KIM-1), and creatinine (Cre) levels for both doses (p < 0.05). Additionally, SFZ treatment significantly decreased histopathological damage, phosphorylated NF-kappa B, toll-like receptor-4 (TLR-4), IL-1 beta, phosphorylated I kappa B-alpha, interleukin-6 (IL-6), TNF-alpha, caspase-3, and caspase-8 levels (p < 0.05). In this study, we found that two different doses of SFZ (50 and 250 mg/kg) showed protective effects by decreasing inflammation and kidney damage in a CLP-induced experimental sepsis model.
