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    The effect of sinularia on spinal cord trauma
    (2020) Kaya, Ismail; Aydin, Hasan Emre; Kaya, Ismail; Ozen, Hulya; Kizmazoglu, Ceren; Atar, Murat; Uzunoglu, Inan; Yuceer, Nurullah
    Aim: Spinal cord traumas have become a serious health problem with the increase in the ageing population in society. The present study aimed to show the anti-inflammatory activity of methylprednisolone and sinularia administered following spinal cord trauma.Materials and Methods: Sea corals are widely found on earth. Sinularia is one of the 17 known active substances of sinularia flexibilis, and several studies have been conducted on its anti-inflammatory, anti-oedema and cytotoxic effects. Despite the recent scientific studies, discussions continue as there are no effective treatment methods in use apart from methylprednisolone; however, the test animals received methylprednisolone treatment to compareits effects with those of sinularia, a secondary active ingredient of s. flexibilis.Results: Paired comparisons for serum IL-1β and tissue TNF-α were made with Dunn's test. When serum IL-1β and tissue TNF-α levels were evaluated, a significant difference was detected in the group taking sinularia treatment compared to the trauma group Sinularia treatment was more efficient on different cytokines and compared to methylprednisolone treatment used routinely, it significantly affected both IL-1β level and TNF-α levels in serumConclusion: Anti-edematous, cytotoxic and anti-inflammatory effects of sinularia have been shown in our study. Sinularia, which has no known harmful effect on the human body according to the literature, may be clinically used in the future; however, more detailed and supportive experimental studies should be conducted on the subject.
  • Küçük Resim
    Öğe
    Manufacturing and application of personal hand and finger splint with three dimensional printer technology following hand and finger trauma
    (2019) Kadioglu, Emine; Aydin, Hasan Emre; Kaya, Ismail; Aydin, Nevin; Sahin, Meryem Cansu
    Aim: To manufacture personal hand and finger splint with three dimensional printer, applying in emergency service patients and comparing with traditional splint applications.Material and Methods: Personal hand-finger splints were manufactured using three dimensional printer and applied to 25 patients referring to Kutahya Medical Sciences University, Faculty of Medicine, Emergency Medicine Department with upper extremity trauma and requiring hand-finger splints and these were compared with splints in the market which are medical products manufactured with traditional methods for cost, patient comfort and treatment efficiency.Results: 11 (44%) traffic accidents, 8 work accidents (32%) and 6 (24%) simple home accidents were detected in trauma etiology distribution. Based on the pathologies of the cases, 9 (36%) soft tissue pathologies, 5 (20%) proximal phalangeal, 4 (16%) distal phalangeal, 2 middle phalangeal, 3 (12%) metacarpal bone and 2 (8%) thumb fractures were found. In the controls made for all patients in the third week, it was observed that their complaints were over, they didn’t need splints anymore and there was recovery in fusion and soft tissue traumas in control x-rays. In the follow-ups of these cases, it was detected that they easily returned to their daily activities.Conclusion: In our study, personal hand-finger splints were manufactured and applied to 25 patients using 3 dimensional printer. For all cases, complete recovery was detected in the controls of all cases and fusion was provided based on control x-rays and they easily returned to their daily activities.Keywords: Finger splint; trauma; 3D printer.