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    Therapeutic effects of melatonin and quercetin in improvement of hepatic steatosis in rats through supression of oxidative damage
    (Comenius Univ, 2017) Esrefoglu, M.; Cetin, A.; Taslidere, E.; Elbe, H.; Ates, B.; Tok, O. E.; Aydin, M. S.
    BACKGROUND: Non-alcoholic steatohepatitis, a cause of cirrhosis, is characterized by fatty infiltration of the liver, inflammation, hepatocellular damage and fibrosis. The aim of the present study was to investigate the effects of melatonin and quercetin on CCl4-induced steatosis characterized by fatty infiltration of the liver, inflammation, hepatocellular damage and fibrosis. METHODS: Rats were divided into 5 groups: Ethanol, Olive oil, CCl4, CCl4+Melatonin (CCl4+Mel), CCl4+Quercetin. Rats were sacrificed and livers were removed for being evaluated by histopathological, immunohistochemical and biochemical methods. RESULTS: In CCl4 group, vacuolization, vascular congestion, haemorrhage, necrosis, and inflammatory infiltration were identified. The mean tissue MDA level was increased, whereas GSH level and SOD and CAT activities were decreased in comparison with ethanol and olive oil groups. MDA levels were decreased in CCl4+Quercetin and CCl4+Mel groups versus CCl4 group. CAT activity of CCl4+Mel group was higher than that of CCl4 and CCl4+Quercetin groups. The mean tissue GSH level of CCl4+Mel group versus CCl4 group was significantly increased. CONCLUSIONS: By the means of histopathological examination, we suggest that both agents are beneficial against necrotic and apoptotic cell death during steatosis. Thus, melatonin and quercetin might be beneficial in the improvement of hepatic steatosis by supporting conventional therapy in humans (Tab. 1, Fig. 5, Ref. 53). Text in PDF www.elis.sk.