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Öğe Combating endometriosis by blocking proteasome and nuclear factor-?B pathways(Oxford Univ Press, 2008) Celik, Onder; Hascalik, Seyma; Elter, Koray; Tagluk, M. E.; Gurates, Bilgin; Aydin, N. E.BACKGROUND: The objective of this study is to investigate the effect of pyrrolidine dithiocarbamate [PDTC; a nuclear factor-kappaB (NF-kappa B) inhibitor] and bortezomib (Velcade; a proteasome inhibitor) on the development of experimental endometriotic implants in rats. METHODS: Endometriosis was surgically induced in 30 rats using the method of Vernon and Wilson. Three weeks later the viability and volume of the implants were recorded and classified. Afterwards, rats were put into three groups with equal numbers. The groups were labelled as the control, the PDTC and the bortezomib groups. Seven days after treatment, a third laparotomy was done and the volume of implants was measured again. The animals were then sacrificed, and the implants were stained with Ki67, proliferating cell nuclear antigen (PCNA), CD34, CD31 and Masson's trichrome histochemical staining. RESULTS: In 80% of the implanted rats, vesicles at the suture region were observed, and the rats graded according to average vesicle diameter (D) as: Grade 1 (no vesicle, 20% of rats), Grade 2 (D < 2 mm, 33.3% of rats), Grade 3 (2 mm < D > 4.5 mm, 26.7% of rats) and Grade 4 (D > 4.5 mm, 20% of rats). After treatment with PDTC or bortezomib, these percentages were decreased for Grades 3 and 4, and increased in Grade 1. The post-treatment implant volumes were decreased in the PDTC and bortezomib groups (P < 0.002 and P < 0.001), and slightly increased in the control group (P = 0.279). In the PDTC and bortezomib groups, CD34, CD31, PCNA and Ki67 expression levels were similar but were significantly reduced compared with the control group. CONCLUSIONS: PDTC and bortezomib may represent a novel therapeutic strategy for treatment of endometriosis.Öğe The effects of Teucrium polium on ionizing radiation-induced intestinal damage in rats(Univ Catholique Louvain-Ucl, 2011) Demirel, U.; Harputluoglu, M. M. M.; Us, S. B.; Kaya, E.; Sahin, N.; Aydin, N. E.; Gursoy, S.Background and study aims : Oxidative stress plays an important role in development of intestinal injury after abdomino-pelvic radiation therapy. Teucrium poliuin (TP) is a medicinal plant which has antioxidant and anti-inflammatory properties. The aim of this study was to investigate the effect of TP on radiation-induced intestinal oxidative damage in rats. Materials and methods : Group 1 (n = 8), the control group; Group 2 (n = 8), the RAD (radiation) group in which each rat received a single whole-body 800 cGy radiation performed with a LINAC; Group 3 (n = 8), the RAD + TP group in which rats were exposed to radiation as in Group 2, followed by intragastric administration of 0.5 g/kg/daily TP extract for 7 consecutive days; and Group 4 (n = 8), the TP group, rats received only intragastric TP for 7 days. Results : Radiation led to intestinal damage, which was accompanied by an increase in intestinal thiobarbituric-acid-reactive substances (TBARS) and myeloperoxidase (MPO) levels, and a decrease in reduced glutathione (GSH) levels. Although TP significantly decreased intestinal MPO levels and inflammation scores, it neither reverted intestinal TBARS and GSH levels nor ameliorated other histological parameters of the disease. Conclusions : Our results suggest that TP reduces inflammation but does not ameliorate the increased oxidative stress conditions in radiation-induced intestinal damage in rats. (Acta gastroenterol. belg., 2011, 74, 491-496).Öğe Longstanding skin ulcers due to Mycobacterium tuberculosis in a healthy man(Malaysian Soc Parasitology Tropical Medicine, 2010) Sahin, N.; Aydin, N. E.; Senol, M.; Ozerol, I. H.Cutaneous tuberculosis, a rare form of extrapulmonary tuberculosis, has a wide variety of clinical presentations and continues to be one of the most important dermatological diseases in developing countries. The sites of predilection are neck, supraclavicular region, axilla, and groin. Single or multiple cutaneous and subcutaneous nodules first appear and breakdown later resulting in undermined ulcers with a purulent discharge, sinuses, and disfiguring scars. We report a multifocal case of scrofuloderma in a 47-year-old immunocompetent man treated successfully with four antituberculotic drugs, albeit lately due to the loss of awareness to the disease.Öğe Pathologic characteristics of resected hepatocellular carcinomas(Springer, 2016) Nurkabul, Z.; Samdanci, E. Turkmen; Aydin, N. E.; Akatli, A. N.; Sahin, N.; Dagli, A. F.; Cakir, E.[Abstract Not Available]Öğe Spectroscopy analysis of cervical carcinoma originated from endometrial carcinoma(Informa Healthcare, 2012) Celik, O.; Yilmaz, E.; Boz, M.; Hascalik, S.; Karakas, H. M.; Aydin, N. E.[Abstract Not Available]Öğe Therapeutic efficiency of atosiban, an oxytocin receptor antagonist in the treatment of experimental endometriosis(Oxford Univ Press, 2011) Simsek, Y.; Celik, O.; Yilmaz, E.; Karaer, A.; Koc, O.; Aydin, N. E.[Abstract Not Available]
