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Öğe Amyloidosis cutis dyschromica: A case treated with acitretin(Wiley, 2005) Ozcan, A; Senol, M; Aydin, NE; Karaca, SWe report a case of amyloidosis cutis dyschromica with diffuse postinflammatory-type hypo- and hyperpigmentation all over the body. The diagnosis was confirmed with routine light microscopic and immunohistochemical staining methods. The patient was treated with acitretin with a good response.Öğe Atypical reactive ovarian surface epithelium, a pitfall in pathologic assessment(Lippincott Williams & Wilkins, 2006) Aydin, NE; Çelik, Ö; Hasçalik, S; Edali, MNA 21-year-old parous woman was operated on due to a torsioned huge hemorrhagic benign ovarian mass. A wedge biopsy of the contralateral ovary revealed endophytic superficial cell clusters with atypical features raising suspicion of malignancy. Detailed pathologic and clinical workup proved these foci as reactive ovarian surface epithelium contrary to various initial interpretations as metastatic, deciduoid, or histiocytic by expert pathologists.Öğe Autoclaving the ossicles provides safe autografts in cholesteatoma(Elsevier Sci Ltd, 2002) Miman, MC; Aydin, NE; Öncel, S; Özturan, O; Erdem, TObjective: The choice of the graft in ossicular chain reconstruction during middle ear surgery for cholesteatoma is a subject still discussed on. In order to clarify the discussion of reuse of the autologous ossicles obtained during middle ear surgery for cholesteatoma. we evaluated the probability of residual disease histologically and the safety of the ossicles after autoclavization, the most promoting alternative method to eradicate residual cholesteatoma and infection on them. Methods: The specimens used in this study were eroded twenty-seven ossicles (22 incuses, 5 malleoli) which were removed from the 27 consecutive patients operated because of cholesteatomato us middle ear disease. They were grouped as follows: Group 1, Fifteen ossicles examined histopathologically directly. Group 2, Five ossicles autoclaved for 20 min at 134 C and then examined histopathologically. Group 3, Five ossicles autoclaved for 20 min at 134 C after mechanical surface cleaning by a fine diamond drill, examined histopathologically. Group 4, Two ossicles removed from two different patients were placed in their mastoid cavities in order to be examined after access in the second-look operation. While one ossicle was only autoclaved, the other was mechanically cleaned by a drill before autoclavization (for 20 min at 134 C). The ossicles were examined histopathologically after the removal at the second stage operation performed 12 months later. Results: In Group 1, all ossicles showed evidence of periosteal thickening. Additional findings were surface cholesteatoma or epithelia in 13 ossicles, surface inflammation in 12 ossicles, granulation tissue in 10 ossicles, osteitis in six ossicles. In Group 2, all five ossicles had preserved their lamellar structure but, no vital cells were seen. The lacunes that had the osteocytes was almost completely empty. The inflammatory cells were eliminated from the ossicles. In Group 3, ossicles were found well preserved with their lamellar structures and contours, with empty lacunes and eliminated inflammatory cells. In Group 4, in two ossicles of this group the lacunes were replaced by the new migrated viable osteocytes with evidence of new bone formation and neovascularisation. No new inflammatory focus or epithelia were found on the surfaces of the ossicles. The shape and the contour of the ossicles remained unchanged. Conclusion: In cholesteatoma surgery, ossicles with minimal erosion and adequate thickness can be used after autoclavization. In this study, it was observed histopathologically that the autoclaving autologous ossicles before ossiculoplasty in cholesteatomatous middle ear is a safe and reliable method. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.Öğe Echinococcal hydatid cyst at the right ventricle outlet with leakage to the pulmonary artery outflow causing follicular airway disease and sudden death(Lippincott Williams & Wilkins, 2001) Aydin, NE; Ege, E; Selçuk, MA; Erguvan, RPostmortem examination of a 35-year-old parous woman who died suddenly revealed a hydatid cyst mass located at the right ventricular outlet, with a grossly discernible defect opening to the pulmonary outflow tract. Pulmonary hemorrhage, follicular bronchitis, and bronchiolitis also were present, with severe acute purulent exudation in the airways. Hydatid cyst complications must be kept in mind when dealing with sudden deterioration and death in patients who are residents of regions where echinococcosis is endemic.Öğe Effect of CO2 laser on spinal epidural fibrosis(Springer-Verlag Wien, 1996) Colak, A; Bavbek, M; Aydin, NE; Renda, N; Acikgoz, BIn this study the effect of CO2 laser on spinal epidural fibrosis was examined in 24 guinea pigs which were divided into two groups. The first group was the control group, the second one the CO2 laser group. All animals had laminectomies at 3 levels. Re-exploration was performed three months after the laminectomy. In the second group the same procedure was performed but at the end of the re-exploration, CO2 laser irradiation of the epidural fibrotic tissue was done. The wounds in both groups were closed again. Four months later all animals were sacrificed. for verification and quantification of scar formation (postoperative fibrosis) light microscopic examinations and determination of hydroxyproline were done, using Bergman's spectrophotometric method. The differences which were observed between the two groups were statistically significant (U:134, p < 0.05). This study demonstrates the reducing effect of CO2 laser irradiation on epidural scar formation. The findings encourage its use as an alternative method of prevention of epidural fibrosis after spinal surgery.Öğe Effect of water extract of Turkish propolis on tuberculosis infection in guinea-pigs(Academic Press Ltd- Elsevier Science Ltd, 2004) Yildirim, Z; Hacievliyagil, S; Kutlu, NO; Aydin, NE; Kurkcuoglu, M; Iraz, M; Durmaz, RMycobacterium tuberculosis (H37Rv)-infected guinea-pig model was used to investigate the effect of water extract of propolis (WEP). After subcutaneous inoculation of tubercle bacilli, each animal received oral WEP (n = 9), isoniazid (n = 5) or saline (n = 6) as placebo and were sacrificed 30 days later. Formation of necrosis was less prominent in the group treated with WEP, but was not statistically significant (P > 0.05). The granuloma formation in the same group was more prominent than the placebo and isoniazid groups; however, this finding failed to reach statistical significance by the Kruskal-Wallis test (P > 0.05). These findings suggest that Turkish WEP may have a limited effect on the development of tuberculosis infection in this guinea-pig model. (C) 2003 Elsevier Ltd. All rights reserved.Öğe Eosinophilic cystitis -: A rare inflammatory pathology mimicking bladder neoplasms(Karger, 2003) Kiliç, S; Erguvan, R; Ipek, D; Gökçe, H; Günes, A; Aydin, NE; Baydinç, CPurpose:We present a large series of eosinophilic cystitis including 8 cases; 3 of them had tumor-like lesions. Materials and Methods: The archives of pathology clinic of Inonu University Medical Faculty were reviewed from 1988 to 2002. The characteristics of patients and their diseases were recorded. Data obtained from 180 cases (172 from the literature and 8 from the present series) was assessed. Results: Seven cases had symptoms such as dysuria, frequency, hematuria, suprapubic pain, and difficulty in voiding. One asymptomatic case with history of bladder carcinoma was diagnosed during routine cystoscopy. The findings were microhematuria in 6 cases, macrohematuria in 2, pyuria in 3, urinary infection in 1, eosinophilia in 1, hyperazotemia in 1, and bladder masses in 3. Cystoscopies detected edematous and erythematous areas in 5 cases and lesions mimicking bladder carcinoma in 3. One case did not take further treatment after cystoscopy and biopsy and completely recovered. Four cases underwent medical therapy with nonsteroidal anti-inflammatory drugs and antihistaminics. They became asymptornatic and control cystoscopies showed no abnormal finding. Two of three patients with mass lesions recovered after steroid therapy following transurethral resection. The lesion in the third recurred and he improved after a second course of steroid therapy. Conclusions: Eosinophilic cystitis is a rare pathology. Sometimes, it may simulate bladder malignancies. Biopsy is mandatory at diagnosis. Usually, it has a benign course and may be treated with fulguration, analgesics, antihistaminics and steroids, although recurrence is possible. Copyright (C) 2003 S. Karger AG, Basel.Öğe Epidermoid carcinoma arising in chronic lymphedema(W B Saunders Co Ltd, 2003) Bilen, BT; Gürlek, A; Alaybeyoglu, N; Çelik, M; Aydin, NELymphangiosarcoma is a well recognized complication of chronic lymphedema, but epidermoid carcinoma is rarely seen. (C) 2003 Elsevier Ltd. All rights reserved.Öğe Evolution of forensic autopsy and current legal procedures in Turkey(Lippincott Williams & Wilkins, 2004) Çagdir, S; Celbis, O; Aydin, NE; Soysal, ZThe first documented forensic autopsy in Turkey was in 1843 during the Ottoman period. In this article, the evolution and current legal procedures regarding forensic autopsies with emphasis on current legal procedures following the declaration of Turkish Republic in 1923 are delineated.Öğe Fox-Fordyce disease(European Acad Dermatology & Venereology, 2003) Ozcan, A; Senol, M; Aydin, NE; Karaca, S; Sener, S[Abstract Not Available]Öğe Gliofibroma(Sage Publications Ltd, 2004) Erguvan-Önal, R; Ates, O; Önal, C; Aydin, NE; Koçak, AAlthough gliofibroma is a rare and incompletely characterized tumor, recent publications have revealed new aspects of this entity. The case of a 16-year-old boy who was diagnosed as having a gliofibroma is presented here, and the problems regarding nosology are discussed in the light of the recent literature.Öğe Histopathologic examination for Helicobacter pylori as a possible etiopathogenic factor in laryngeal carcinoma(Karger, 2006) Kizilay, A; Saydam, L; Aydin, A; Kalcioglu, MT; Ozturan, O; Aydin, NEObjective: We investigated the presence of Helicobacter pylori in laryngeal cancer specimens to reveal whether or not this is a risk factor in the development of squamous cell carcinoma of the larynx. Methods: Sixty-nine total laryngectomy specimens with the pathologic diagnosis of squamous cell carcinoma and 30 laryngeal tissue samples that had been taken for the investigation of nonneoplastic (polyp, nodule) diseases were studied. Specimens of both tumor and control groups were stained with hematoxylin-eosin and modified Giemsa stains, and then they were examined under a light microscope. Results: In both groups, H. pylori could not be found in any of the cases. Conclusion: The histologic examination of our series did not reveal any clue related to the possible etiologic association between H. pylori and squamous cell carcinoma of the larynx.Öğe Immunohistochemistry of tuberculin skin test(Oxford Univ Press, 2004) Mizrak, B; Aydin, NE; Hazneci, E; Yakinci, C[Abstract Not Available]Öğe Intraventricular solitary fibrous tumor(Lippincott Williams & Wilkins, 2004) Koçak, A; Çayli, SR; Saraç, K; Aydin, NEOBJECTIVE AND IMPORTANCE: Intracranial solitary fibrous tumours, have described previously, but intraventricular solitary fibrous tumors are extremely rare. We present what is, to our knowledge, the first reported case of solitary fibrous tumor in the third ventricle. CLINICAL PRESENTATION: A 63-year-old man presented with weakness of his lower extremities and headaches. Computed tomography and magnetic resonance imaging of the brain revealed an enhancing mass in the posterior part of the third ventricle. INTERVENTION: The tumor originated from the wall of the left internal cerebral vein and extended to the posterior part of the third ventricle. Nearly total excision was performed via an infratentorial-supracerebellar approach. CONCLUSION: The differential diagnonis of intracranial solitary fibrous tumors includes fibroblastic meningioma, meningeal hemangiopericytoma, neurofibroma, and schwannoma. The differential diagnosis in the present case was greatly helped by the immunohistochemical and ultrastructural findings, along with a disease-free 3.5-year follow-up. These findings are presented with reference to previous.Öğe Malignant melanoma of the soft parts showing calciphylaxis(Taylor & Francis Inc, 2003) Kutlu, NO; Aydin, NE; Aslan, M; Bulut, T; Özgen, ÜCalciphylaxis is a poorly understood and highly morbid syndrome of vascular calcification and skin necrosis. Hypercalcemia, hyperphosphatemia, and secondary hyperparathyroidism are the factors implicated in the pathogenesis of calciphylaxis, which is generally identified in patients with hyperparathyroidism secondary to end-stage renal disease. It has also been observed in primary hyperparathyroidism, end-stage liver disease, and rheumatoid arthritis, in the absence of renal disease. There are few case reports of calciphylaxis occurring in hypercalcemia of malignancy. An unusual case is reported of calciphylaxis associated with malignant melanoma of the soft parts in the absence of renal or parathyroid disease. This is the first reported case of this soft tissue sarcoma showing calciphylactic changes.Öğe Öğe Pleomorphic lipoma of the tongue(Mosby, Inc, 2002) Atik, E; Usta, U; Aydin, NE[Abstract Not Available]Öğe Pleuropulmonary blastoma: report of a case presenting with spontaneous pneumothorax(Elsevier Science Bv, 2001) Kuzucu, A; Soysal, O; Yakinci, C; Aydin, NE[Abstract Not Available]Öğe Polymerase chain reaction technology for forensic postmortem specimens(Lippincott Williams & Wilkins, 1999) Aydin, NE[Abstract Not Available]Öğe Primary cutaneous amyloidosis(Royal Soc Medicine Press Ltd, 2002) Aydin, NE[Abstract Not Available]
