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    Erythrocyte and plasma superoxide dismutase activities in acute appendicitis
    (1998) Koltuksuz U.; Uz E.; Gursoy H.; Demircan M.; Aydinc M.; Mutus M.; Cetin S.
    Although the role of oxygen free radicals in many inflammatory diseases has been well known, it has not been thoroughly investigated in the inflammatory diseases, of the abdomen. In order to investigate the possible role of oxygen free radicals in the mechanism of progression following the onset of inflammation, blood samples from 18 patients diagnosed as acute appendicitis and 10 healthy children as controls were collected. After plasma and erythrocytes of the blood samples were separated, superoxide dismutase (SOD) activities were measured in these compartments. Additionally, the patients with appendicitis were divided into perforated (n=8), and nonperforated (n=10) subgroups, according to intraoperative examination findings and histopathological classification. SOD activities were compared statistically between these two groups, and the control group. A significant difference in SOD activity between perforated and nonperforated appendicitis in both plasma and erythrocyte was observed (plasma: 4.2±1.7 and 2.0±0.7 U/ml, p<0.05; erythrocyte: 1690.7±799.6 and 1104.2±225.1 U/grHb, p<0.05). The difference between the nonperforated group and control group was not significant, whereas there was a significant difference between the perforated and control groups (plasma: 4.2±1.7 and 2.6±0.9 U/ml, p<0.05; erythrocyte: 1690.7±799.6 and 1148.8±152.2 U/grHb, p<0.05). According to these results, we may speculate that free oxygen radicals released from polymorphonuclear leucocytes following an inflammatory condition may play an important role in the progression of acute appendicitis with the contribution of some other possible factors.
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    Intraoperative laparoscopy by a flexible scope: is it reliable in contralateral childhood hernias?
    (1997) Gursoy M.H.; Gurel M.; Koltuksuz U.; Uguralp S.; Aydinc M.
    BACKGROUND AND OBJECTIVES: Negative contralateral groin exploration for childhood hernias raises the question of whether contralateral groin exploration is necessary or not. To find out whether a contralateral processus vaginalis was patent, we performed laparoscopy with a flexible scope. METHODS: After carbon dioxide insufflation, a flexible laparoscope was inserted through the opened hernia sac and the contralateral processus vaginalis orifice was examined. We considered a patent processus vaginalis as a potential hernia. The study involved 20 children: 16 boys and 4 girls. The symptomatic side was explored in a conventional manner and laparoscopy was performed through the opened hernia sac. RESULTS: A contralateral processus vaginalis was found in 6 children: 4 boys and 2 girls. These results were confirmed by exploring the opposite groin. We did not explore if the laparoscopic examination was within normal limits. There was one false-positive result in a female patient. CONCLUSIONS: Intraoperative non-puncture laparoscopy utilizing a flexible laparoscope through the hernia opening is an uncomplicated, reliable and precise method for identifying a patent contralateral processus vaginalis. It may represent a satisfactory alternative to routine bilateral inguinal exploration. Also, use of the flexible laparoscope may be more beneficial than use of a rigid laparoscope passed through the umbilicus or hernia sac.