Yazar "Aydogan, Hakan" seçeneğine göre listele

Listeleniyor 1 - 2 / 2
  • Küçük Resim Yok
    Öğe
    Effects of high dose corticosteroids in open rhinoplasty
    (Elsevier Sci Ltd, 2009) Guerlek, Ali; Fariz, Alpay; Aydogan, Hakan; Ersoez-Oeztuerk, Ayse; Evans, Gregory R. D.
    Background: Although some studies about the effects of steroids on surgical. trauma in closed or combined (closed and open together) rhinoplasty have been reported in the literature, still more information is needed in order to enlighten rhinoplasty surgeons. The purpose of this study is to evaluate the anti - inflammatory activity of steroids administered in high doses to prevent and decrease periorbital. ecchymosis and oedema in patients who underwent open rhinoplasty with osteotomies by the same surgeon. This is the first study in open rhinoplasty atone. Methods: The study was performed on 40 patients, under general anaesthesia. Patients were divided randomly into five groups (eight patients in each group); the groups comprised: a single 250 mg dose of methylprednisolone (Group I), a single 500 mg dose of methylprednisolone (Group II), four 250 mg doses of methylprednisotone (Group III), four 500 mg doses of methylprednisotone (Group IV) and placebo (Group V). Digital photographs were taken of each patient on the first, third and seventh postoperative days. Scorings of eyelid swelling and ecchymosis were evaluated separately using a graded scale from 0 to (+) 4 by three observers, independently. Additionally, blood samples were taken for the evaluations of C-reactive protein (CRP), white blood cell (WBC) and erythrocyte sedimentation rate (ESR) on the same days. Results: Clinically and statistically significant difference was observed in the decrease of both ecchymosis and oedema, between the placebo and high dose methylprednisolone groups, which is effective to prevent and to decrease both the ecchymosis and oedema in open rhinoplasty with osteotomies. CRP was the most sensitive acute phase reactant among CRP, ESR and WBC. No complication was observed due to steroid usage. Conclusions: We can confidently say that high dose methylprednisolone is effective in preventing and reducing both the periorbital ecchymosis and oedema in open rhinoplasty with osteotomies and it can be used safety for this purpose. (C) 2008 Published by Elsevier Ltd on behalf of British Association of Plastic, Reconstructive and Aesthetic Surgeons.
  • Küçük Resim Yok
    Öğe
    The protective effect of aminoguanidine on random pattern skin flap survival
    (Ortadogu Ad Pres & Publ Co, 2007) Aydogan, Hakan; Guerlek, Ali; Parlakpinar, Hakan; Aydogan, Nilay; Acet, Ahmet
    Objective: Distal flap necrosis resulting from ischemia is a serious problem, and increases the cost of treatment. Reactive oxygen radicals (ROS) play an important role in tissue injury and ischemia, and may lead to partial or complete flap necrosis. Aminoguanidine (AG), a potent antioxidant, prevents ROS formation and lipid peroxidation. Besides, AG inhibits inducible nitric oxide synthase (iNOS) leading to decreased generation of nitric oxide (NO). Material and Methods: Rats were randomly divided into three groups: Control, flap elevated saline group, and AG treated group. A caudally based rectangular flap, 3 x 10-cm was elevated on the back of the rats. Flap viability was evaluated 7 days after the initial operation, measuring necrotic areas and total flap areas by computer-assisted planimetry. Malondialdehyde (MDA), NO, glutathione (GSH), glutathione peroxidase (GSH-Px), and superoxide dismutase (SOD) levels were measured in flap skin tissue to observe the effects of AG. Results: Rate of flap necrosis and MDA, NO levels were higher in the saline group compared to the control group, while GSH, GSH-Px, and SOD enzyme activities were reduced. AG administration reduced lipid peroxidation, NO generation and increased GSH, GSH-Px, SOD enzyme activities. Furthermore, it significantly reduced the rate of flap necrosis when compared with the saline group. Conclusion: We believe that AG, a potent antioxidant and iNOS inhibitor, has beneficial effects to improve skin flap viability when distal flap necrosis is a potential complication in longer flaps.