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Öğe Administration of MINE protocol in untreated patients with intermediate and high grade non-Hodgkin's lymphoma(Vsp Bv, 1997) Aydogdu, I; Koc, H; Ilhan, O; Gurman, G; Akan, H; Beksac, M; Konuk, NIn recent years, more effective and less toxic treatment protocols have been developed to increase the cure rates in intermediate and high grade non-Hodgkin's lymphoma (NHL). This study was undertaken to investigate the efficacy and toxicity of MWE (ifosfamide, mesna, mitoxantrone and etoposide) combination chemotherapy in patients with intermediate and high grade NHL. Twenty-one patients (16 male, 5 female; age between 26 and 70 years) with NHL were included in the study. An overall response rate of 73% and complete response rate of 56% were achieved and survival rate for responding patients was 80% at the 48th month. Side effects including mild myelosuppression, nausea/vomiting and alopecia were observed. MINE combination seems to be effective and well tolerated without significant toxicity as a first-line therapy in patients with intermediate or high grade NHL.Öğe Autoimmune haemolytic anaemia and thrombocytopenia associated with ciprofloxacin(Blackwell Science Ltd, 1997) Aydogdu, I; Ozerol, IH; Tayfun, E; Harputluoglu, M[Abstract Not Available]Öğe Bilateral hearing loss during vincristine therapy: A case report(E I F T Srl, 2003) Kalcioglu, MT; Kuku, I; Kaya, E; Oncel, S; Aydogdu, IVincristine sulfate is a chemotherapeutic agent used in different cancer therapies. It is also the first choice of treatment for peripheral T-cell lymphoma with cyclophosphamide and adriamycin. Sudden hearing loss during vincristine therapy is a very rare event. This is a case of a 16-year old girl who developed sudden bilateral hearing loss related to vincristine therapy.Öğe Bilateral transient hearing loss associated with vincristine therapy: Case report(E I F T Srl, 2000) Aydogdu, I; Ozturan, O; Kuku, I; Kaya, E; Sevinc, A; Yildiz, RVincristine, adriamycin, and dexamethasone (VAD) chemotherapy protocol is first-choice treatment in newly diagnosed multiple myeloma patients in many centers. Sudden hearing loss associated with vincristine therapy is a rarely observed event in the VAD protocol. We describe a 69-year old male patient diagnosed with multiple myeloma 7 months ago who developed sudden bilateral hearing loss related to vincristine therapy. This uncommon adverse effect of vincristine is discussed and the literature reviewed.Öğe Blastic natural killer cell leukaemia with skin involvement: a case report(Wiley, 2004) Kaya, E; Ozcan, H; Kuku, I; Dikilitas, M; Sevinc, A; Aydogdu, INatural killer cell leukaemia is generally accompanied by extramedullary involvement. CD4+ natural killer cell leukaemia frequently manifests with cutaneous involvement. The disease pursues a very aggressive course with no long-term survivors reported. We present a patient with CD4+ natural killer cell leukaemia with skin, bone marrow and peripheral blood involvement who is still on remission at the end of 2 years.Öğe Case report. Rhinocerebral zygomycosis(Blackwell Wissenschafts-Verlag Gmbh, 2001) Aydogdu, I; Sari, R; Mizrak, BA case of rhinocerebral zygomycosis treated with liposomal amphotericin B is described.Öğe Clinical experience with three combination regimens for the treatment of high-risk febrile neutropenia(Acad Medicine Singapore, 2006) Serefhanoglu, K; Ersoy, Y; Serefhanoglu, S; Aydogdu, I; Kuku, I; Kaya, EIntroduction: The objective of this study was to compare the safety and efficacy of ceftazidime (2 g every 8 h), piperacillin/tazobactam (4 g/500 mg every 6 h), and meropenem (1 g every 8 h), when combined with amikacin (15 mg/kg once daily), in the empirical treatment of high-risk febrile neutropenic episodes in patients with haematological malignancy. Materials and Methods: A prospective, comparative study designed in the haematology unit of a university hospital in Turkey. Results: A total of 89 febrile episodes in 60 neutropenic patients were treated; 29 febrile episodes in 23 patients with ceftazidime plus amikacin (group 1), 30 episodes in 25 patients with piperacillin/tazobactam plus amikacin (group 2), and 30 episodes in 25 patients with meropenem plus amikacin (group 3). The 3 groups were comparable in terms of age, sex, underlying malignancy, pretherapy neutrophil counts, duration of neutropenia and types of infections. Neutropenia, since the start of fever, persisted for >= 10 days in all of the episodes in the 3 study groups. Nearly all of the episodes were seen in patients with acute leukaemia. In 25.8% (23/89) of the febrile neutropenia episodes, an aetiologic organism was isolated, with gram-negative bacteria being the most commonly isolated. The success without modification rates were 34.5%, 30% and 36.7% for groups 1, 2 and 3, respectively (P > 0.05). After modification with a different class of antimicrobial therapy, the response rates increased to 65.5%, 63.3% and 70% for groups 1, 2 and 3, respectively (P > 0.05). The mean duration of treatment and the time to defervescence were also comparable in all groups. In all arms, side effects were minimal. Conclusions: It is concluded that the 3 regimens were equally effective and safe in the empirical treatment of high-risk febrile neutropenic episodes.Öğe Coincidental acute myeloblastic leukemia in a patient with renal angiosarcoma(Vsp Bv, 1999) Aydogdu, I; Turhan, O; Sari, R; Ates, M; Türk, MA case of acute myeloblastic leukemia diagnosed 7 months after radical nephrectomy for renal angiosarcoma is presented. Chemotherapy or radiotherapy was not performed following nephrectomy and ethiologic factor remains unknown.Öğe The comparison of serum interleukin, growth factor and lactoferrin levels in the primary and reactive thrombocytosis(Blackwell Science Ltd, 1998) Seçkin, Y; Sahin, K; Sari, R; Hartputluoglu, MM; Aydogdu, I; Sevinç, A; Yologlu, S[Abstract Not Available]Öğe Cutaneous metastasis of endometrial carcinoma with hemorrhagic nodules and papules(Imr Press, 2005) Baydar, M; Dikilitas, M; Sevinc, A; Senel, S; Senel, F; Aydogdu, IBackground: Endometrium cancer is the fourth most frequent malignancy in women. However, skin metastasis from endometrium cancer is a very rare entity. Case: A 58-year-old multiparous woman postmenopausal for ten years presented with multiple metastatic, nodular, hemorrhagic skin lesions located at the initial surgery and radiotherapy site 14 months after the original diagnosis was made. Combination chemotherapy was instituted, but the patient died after the second cycle of chemotherapy. Conclusion: Although endometrial cancer is one of the most frequent malignancies in women, skin metastasis from endometrial cancer is very rare. In reported cases metastasis from endometrial cancer has been most commonly noted at the initial surgery and radiotherapy site. Therefore, the initial surgical and radiotherapy site must be examined carefully for skin metastasis.Öğe Decreased Tc-99m MDP uptake in myelonecrosis(Lippincott Williams & Wilkins, 2006) Kekilli, E; Yagmur, C; Kaya, E; Kuku, I; Ertem, K; Aydogdu, I[Abstract Not Available]Öğe Development of large genital ulcer due to hydroxyurea treatment in a patient with chronic myeloid leukemia and Behcet's disease(Taylor & Francis Ltd, 2003) Karincaoglu, Y; Kaya, E; Esrefoglu, M; Aydogdu, IChronic myeloid leukemia (CML) is a myeloproliferative disease arising from abnormal stem cells and associated with splenomegaly and leukocytosis. Hydroxyurea and interferon alpha are used in treatment very frequently. Behcet's disease (BD) is a chronic, repetitive disease of unknown etiology and associated with mucocutaneous, ocular, vascular and central nervous system involvement. Cases with symptoms of BD have been reported during interferon alpha treatment of CML. However, similar symptoms due to hydroxyurea treatment have been reported in only one case until now. A 32-year-old female patient under follow up because of CML and BD, developed a large genital ulcer during hydroxyurea treatment. Ulcers due to hydroxyurea treatment and the co-existence of these two diseases has been reported in only one case in the literature while large genital ulcers have not been reported previously.Öğe The effect of glycemic control on lymphocyte neural cell adhesion molecule (CD 56) expression in patients with type 2 diabetes mellitus(Springer, 2005) Senel, S; Sahin, I; Kaya, E; Taskapan, C; Aydogdu, I[Abstract Not Available]Öğe The evaluation of serum cytokine levels in febrile neutropenic patients(Blackwell Science Ltd, 1998) Seçkin, Y; Sahin, K; Harputluoglu, MM; San, R; Türk, HM; Sevinç, A; Aydogdu, I[Abstract Not Available]Öğe The evaluation of suspected infectious episodes in patients with hematological diseases.(W B Saunders Co, 1996) Aydogdu, I; Buyukberber, S; Duygulu, C; Tayfun, E; Yucesoy, M[Abstract Not Available]Öğe The frequency of gallbladder stones in patients width pernicious anemia(Academic Press Inc Elsevier Science, 2001) Aydogdu, I; Sari, R; Ulu, R; Sevinc, ABackground. Ineffective erythropoiesis and intramedullary hemolysis are the two important results of pernicious anemia. Hemolysis is one of the risk factors in the formation of gallbladder stones. Patients and methods. The frequency of gallstones was searched in 59 patients with pernicious anemia and in 54 healthy subjects. Results. Nineteen (32.2%) patients in the pernicious anemia group and three (5.5%) patients in the control group were detected to have gallstones. Pernicious anemia patients with and without gallbladder stones were also compared for mean corpuscular volume, hemoglobin, unconjugated bilirubin, lactic dehydrogenase, and vitamin B12 levels but no statistically significant difference was encountered. Conclusion. Apart from other risk factors, pernicious anemia itself increases the frequency of gallbladder stones. Should patients with pernicious anemia develop upper-abdominal pain or other symptoms referable to biliary tract disease, a high index of suspicion for gallstone-related disease should be maintained. (C) 2001 Elsevier Science.Öğe Gemcitabine-induced erysipeloid skin lesions in a patient with malignant mesothelioma(European Acad Dermatology & Venereology, 2002) Kuku, I; Kaya, E; Sevinc, A; Aydogdu, IGemcitabine is a nucleoside analogue that has shown to have antineoplastic activity in different solid tumours (lung, pancreas, bladder, colon, ovarian, and breast cancer) and malignant mesothelioma. The toxic effects of gemcitabine include myelosuppression, flu-like syndrome, altered liver function tests, bronchospasm, rash, itching, and fever. However, gemcitabine-induced erysipeloid skin reaction was reported in a small number of patients with previous history of radiotherapy or lymphedema. We reported a male patient who developed erysipeloid skin reaction following gemcitabine treatment in the absence of radiotherapy and lymphedema.Öğe Isolated thrombocytopenia: the presenting finding of typhoid fever(Blackwell Publishing Ltd, 2003) Serefhanoglu, K; Kaya, E; Sevinc, A; Aydogdu, I; Kuku, I; Ersoy, YThrombocytopenia is generally seen as a complication in typhoid fever. However, it can also be encountered as a presenting sign on admission. A 29-year-old man with complaints of fever and diarrhoea was hospitalized because of isolated thrombocytopenia encountered on routine complete blood count examination. The diagnosis of typhoid fever was established when Salmonella typhi was isolated from the blood cultures. The platelet count returned to normal level within the first week of ceftriaxone therapy. Possible mechanisms of thrombocytopenia were discussed.Öğe Late relapse in a patient with acute lymphoblastic leukemia thirteen years after diagnosis(Hemisphere Publ Corp, 1997) Aydogdu, I; Tayfun, E; Ozcan, C; Harputluoglu, M; Ozen, S; Hicsonmez, G[Abstract Not Available]Öğe Metastatic bone marrow tumours: a report of six cases and review of the literature(Vsp Bv, 2001) Sari, R; Aydogdu, I; Ozen, S; Sevinc, A; Buyukberber, SBone marrow aspirations and biopsies are now employed in the investigation of many disorders in haematology, oncology, and internal medicine. In this paper, clinical, laboratory, and pathological findings are presented of patients with bone marrow metastases of solid tumours (n = 6). Anemia was detected in four cases (66.6%), thrombocytopenia in five cases (83.3%), leukopenia in three cases (50%), diffuse bone pain in four cases (66.6%), elevated serum alkaline phosphatase levels in four cases (66.6%), and hypercalcaemia in two cases (33.3%). In conclusion, bone marrow aspiration and biopsy examinations are effective, practical, and cheap in detecting solid tumour metastasis to bone marrow in a selected group of patients.
